FRMD3_MOUSE
ID FRMD3_MOUSE Reviewed; 595 AA.
AC Q8BHD4; A2BEJ6; Q3UF23; Q5SPU0; Q5SPU1; Q8C045;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=FERM domain-containing protein 3;
GN Name=Frmd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J;
RC TISSUE=Embryo, Head, Olfactory bulb, and Sympathetic ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative tumor suppressor gene that may be implicated in the
CC origin and progression of lung cancer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BHD4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BHD4-2; Sequence=VSP_031168;
CC Name=3;
CC IsoId=Q8BHD4-3; Sequence=VSP_031169, VSP_031170;
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DR EMBL; AK032348; BAC27827.1; -; mRNA.
DR EMBL; AK034956; BAC28893.1; -; mRNA.
DR EMBL; AK048561; BAC33375.1; -; mRNA.
DR EMBL; AK149095; BAE28738.1; -; mRNA.
DR EMBL; AL844607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX088570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX957282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112419; AAI12420.1; -; mRNA.
DR EMBL; BC113795; AAI13796.1; -; mRNA.
DR EMBL; BC118964; AAI18965.1; -; mRNA.
DR CCDS; CCDS38789.1; -. [Q8BHD4-1]
DR CCDS; CCDS51212.1; -. [Q8BHD4-2]
DR RefSeq; NP_001157204.1; NM_001163732.1. [Q8BHD4-2]
DR RefSeq; NP_766457.1; NM_172869.4. [Q8BHD4-1]
DR AlphaFoldDB; Q8BHD4; -.
DR SMR; Q8BHD4; -.
DR STRING; 10090.ENSMUSP00000081514; -.
DR iPTMnet; Q8BHD4; -.
DR PhosphoSitePlus; Q8BHD4; -.
DR PaxDb; Q8BHD4; -.
DR PRIDE; Q8BHD4; -.
DR ProteomicsDB; 267518; -. [Q8BHD4-1]
DR ProteomicsDB; 267519; -. [Q8BHD4-2]
DR ProteomicsDB; 267520; -. [Q8BHD4-3]
DR Antibodypedia; 27519; 135 antibodies from 21 providers.
DR DNASU; 242506; -.
DR Ensembl; ENSMUST00000084474; ENSMUSP00000081514; ENSMUSG00000049122. [Q8BHD4-1]
DR Ensembl; ENSMUST00000098006; ENSMUSP00000095615; ENSMUSG00000049122. [Q8BHD4-2]
DR GeneID; 242506; -.
DR KEGG; mmu:242506; -.
DR UCSC; uc008tjg.2; mouse. [Q8BHD4-1]
DR UCSC; uc008tjh.2; mouse. [Q8BHD4-2]
DR CTD; 257019; -.
DR MGI; MGI:2442466; Frmd3.
DR VEuPathDB; HostDB:ENSMUSG00000049122; -.
DR eggNOG; KOG3530; Eukaryota.
DR GeneTree; ENSGT00940000158577; -.
DR HOGENOM; CLU_003623_1_7_1; -.
DR InParanoid; Q8BHD4; -.
DR OMA; CPLRQWM; -.
DR PhylomeDB; Q8BHD4; -.
DR TreeFam; TF343477; -.
DR BioGRID-ORCS; 242506; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Frmd3; mouse.
DR PRO; PR:Q8BHD4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BHD4; protein.
DR Bgee; ENSMUSG00000049122; Expressed in lumbar dorsal root ganglion and 79 other tissues.
DR Genevisible; Q8BHD4; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FERM-adjacent.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..595
FT /note="FERM domain-containing protein 3"
FT /id="PRO_0000318099"
FT TRANSMEM 529..549
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 32..312
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT VAR_SEQ 1..352
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031169"
FT VAR_SEQ 353..356
FT /note="PEVH -> MSVF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031170"
FT VAR_SEQ 551..595
FT /note="GIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVNIVLYMLGCS -> VSM
FT P (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_031168"
FT CONFLICT 405
FT /note="M -> V (in Ref. 1; BAC27827)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 595 AA; 68448 MW; 2EB221C15159EE61 CRC64;
MFASCHCAPR GRRTMKMIHF RSSSIKSLNQ EMKCTIRLLD DSEVSCHIQR ETKGQFLIEY
ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKSH PPYTMCFRVK FYPHEPLKIK
EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEF GDYYPDEHPE NYISEFEIFP
KQSQKLERKI MEIHNNELRG QSPAIAEFNL LLKAHTLETY GVDPHPCKDS RGATAFLGFT
AAGFVVFQGN KRIHLRKWSD VCKLKFEGKT FYVIGSQKEK NAVLAFHTST PAACKHLWKC
GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR DPPEVHRVNI
TQSRSFHSLN KQLIINMEPL QPLLPSPTEQ EEEVPVGEGV PLPKMDVSEP LIASSPVKGA
QCADPPDEEE DRVKEDPLTI SELAYNPSAS LLPTPVDDDE INMLFDCPSR LELEREDTDS
FEELEADENA FLIAEEEELK EARQALSWSY SILTGHIWVN PLVKSFSRLL VVGLGLLLFV
FPLLLLLLES GIDLSFLCEI RQTPEFEQFH YEYYCPLKEW VAGKVNIVLY MLGCS
