ID   FRMD3_XENTR             Reviewed;         600 AA.
AC   Q0P4Q4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=FERM domain-containing protein 3;
GN   Name=frmd3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI21951.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC121950; AAI21951.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001072510.1; NM_001079042.1.
DR   AlphaFoldDB; Q0P4Q4; -.
DR   SMR; Q0P4Q4; -.
DR   PaxDb; Q0P4Q4; -.
DR   DNASU; 779965; -.
DR   Ensembl; ENSXETT00000036577; ENSXETP00000036577; ENSXETG00000016772.
DR   GeneID; 779965; -.
DR   KEGG; xtr:779965; -.
DR   CTD; 257019; -.
DR   Xenbase; XB-GENE-1011845; frmd3.
DR   eggNOG; KOG3530; Eukaryota.
DR   HOGENOM; CLU_003623_1_7_1; -.
DR   InParanoid; Q0P4Q4; -.
DR   OMA; CPLRQWM; -.
DR   OrthoDB; 484046at2759; -.
DR   TreeFam; TF343477; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016772; Expressed in 4-cell stage embryo and 10 other tissues.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FERM-adjacent.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..600
FT                   /note="FERM domain-containing protein 3"
FT                   /id="PRO_0000318101"
FT   TRANSMEM        534..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          31..311
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          413..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   600 AA;  69061 MW;  A7F99261B57E96A5 CRC64;
     MFGCQCPRKK KGTMTMMRLR TASLRSLNLD MRCTIRLLDD TEISFNIQRD TKGQFLLDYI
     CNHYNLLEKD YFGIRFVDPE KQRHWLDPSK PVAKQMKSHP PYTMCFRVKF YPHEPLKIKE
     ELTRYLLYLQ IKRDIFHGRL LCCFADAAFL GACIVQAEIG DYDPDEHPDN YICDFKIFPK
     QSQKLERKIV EIHKNELRGQ SPSVSEFNLL LKAHSLETYG VDPHPCKDST GTTTFLGYTA
     AGFVVFQGNK RIHLIKWPDI CKMKFDGKTF HVVVMQKEKK NILTYHTSTP AACKHLWKCG
     VENQAFYKYA KSSQVKTVTS SNIFFKGSRF RYCGKVAKEV VEASSKIQRD PPEVHRSLIP
     HSRSSYSLNK QLIINMEPLQ PLIPSPNEEE EEEEEENQID EGILLLQQSE ASSAPVLGNS
     PARGLETTAD VTHDEEESIR EEPLTISEQV YNPSASLLPT PVDEGIDMLF NSPLRAEREK
     DDTDSFEDLE ADEHAFLIAE EEEMKEARKA LSWSYNFIMG NMQLNAFLKS FSKLLLAAIG
     LLMVVLPLLL ILLESDIDVS FLREIRLTPE FEQFHHEYYC PFRKWVACKL SAALNLFGST