FRMD6_HUMAN
ID FRMD6_HUMAN Reviewed; 622 AA.
AC Q96NE9; D3DSB9; Q5HYF2; Q8N2X1; Q8WUH7;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=FERM domain-containing protein 6;
DE AltName: Full=Willin;
GN Name=FRMD6; Synonyms=C14orf31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hair follicle dermal papilla;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal skin, and Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=16137681; DOI=10.1016/j.febslet.2005.07.097;
RA Gunn-Moore F.J., Welsh G.I., Herron L.R., Brannigan F., Venkateswarlu K.,
RA Gillespie S., Brandwein-Gensler M., Madan R., Tavare J.M., Brophy P.J.,
RA Prystowsky M.B., Guild S.;
RT "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.";
RL FEBS Lett. 579:5089-5094(2005).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542 AND SER-544, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q96NE9; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-741729, EBI-2548012;
CC Q96NE9; Q6YFQ2: COX6B2; NbExp=3; IntAct=EBI-741729, EBI-10291911;
CC Q96NE9; Q96EY1-2: DNAJA3; NbExp=6; IntAct=EBI-741729, EBI-3952284;
CC Q96NE9; O00471: EXOC5; NbExp=3; IntAct=EBI-741729, EBI-949824;
CC Q96NE9; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-741729, EBI-10172181;
CC Q96NE9; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-741729, EBI-2549423;
CC Q96NE9; Q13422: IKZF1; NbExp=3; IntAct=EBI-741729, EBI-745305;
CC Q96NE9; Q6NYC1: JMJD6; NbExp=3; IntAct=EBI-741729, EBI-8464037;
CC Q96NE9; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-741729, EBI-741037;
CC Q96NE9; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-741729, EBI-394607;
CC Q96NE9; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-741729, EBI-10172526;
CC Q96NE9; P40692: MLH1; NbExp=3; IntAct=EBI-741729, EBI-744248;
CC Q96NE9; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-741729, EBI-2212028;
CC Q96NE9; A2RRE0: WDR7; NbExp=3; IntAct=EBI-741729, EBI-10291832;
CC Q96NE9-2; Q9Y2T2: AP3M1; NbExp=3; IntAct=EBI-13213391, EBI-2371151;
CC Q96NE9-2; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-13213391, EBI-11522367;
CC Q96NE9-2; Q92993: KAT5; NbExp=3; IntAct=EBI-13213391, EBI-399080;
CC Q96NE9-2; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-13213391, EBI-11742507;
CC Q96NE9-2; Q9BXY0: MAK16; NbExp=5; IntAct=EBI-13213391, EBI-5280229;
CC Q96NE9-2; P40692: MLH1; NbExp=4; IntAct=EBI-13213391, EBI-744248;
CC Q96NE9-2; Q6ZUT1: NKAPD1; NbExp=3; IntAct=EBI-13213391, EBI-3920396;
CC Q96NE9-2; Q9BYG5: PARD6B; NbExp=3; IntAct=EBI-13213391, EBI-295391;
CC Q96NE9-2; P62937-2: PPIA; NbExp=3; IntAct=EBI-13213391, EBI-25884072;
CC Q96NE9-2; P17252: PRKCA; NbExp=3; IntAct=EBI-13213391, EBI-1383528;
CC Q96NE9-2; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-13213391, EBI-9090795;
CC Q96NE9-2; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-13213391, EBI-745392;
CC Q96NE9-2; Q86UE8: TLK2; NbExp=3; IntAct=EBI-13213391, EBI-1047967;
CC Q96NE9-2; P61981: YWHAG; NbExp=3; IntAct=EBI-13213391, EBI-359832;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16137681}. Cell
CC membrane {ECO:0000269|PubMed:16137681}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16137681}; Cytoplasmic side
CC {ECO:0000269|PubMed:16137681}. Note=Can colocalize with actin.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96NE9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96NE9-2; Sequence=VSP_008023;
CC Name=3;
CC IsoId=Q96NE9-3; Sequence=VSP_008022;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK055545; BAB70950.1; -; mRNA.
DR EMBL; BX161430; CAD61902.1; -; mRNA.
DR EMBL; BX647863; CAI46062.1; -; mRNA.
DR EMBL; AL079307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW65666.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW65671.1; -; Genomic_DNA.
DR EMBL; BC020521; AAH20521.1; -; mRNA.
DR EMBL; BC029870; AAH29870.1; -; mRNA.
DR CCDS; CCDS58318.1; -. [Q96NE9-1]
DR CCDS; CCDS58319.1; -. [Q96NE9-3]
DR CCDS; CCDS9704.1; -. [Q96NE9-2]
DR RefSeq; NP_001035946.1; NM_001042481.2. [Q96NE9-2]
DR RefSeq; NP_001253975.1; NM_001267046.1. [Q96NE9-1]
DR RefSeq; NP_001253976.1; NM_001267047.1. [Q96NE9-3]
DR RefSeq; NP_689543.1; NM_152330.3. [Q96NE9-2]
DR RefSeq; XP_006720092.1; XM_006720029.1. [Q96NE9-1]
DR RefSeq; XP_006720093.1; XM_006720030.1. [Q96NE9-2]
DR RefSeq; XP_011534725.1; XM_011536423.1. [Q96NE9-1]
DR RefSeq; XP_011534726.1; XM_011536424.1. [Q96NE9-1]
DR AlphaFoldDB; Q96NE9; -.
DR SMR; Q96NE9; -.
DR BioGRID; 125795; 50.
DR IntAct; Q96NE9; 65.
DR MINT; Q96NE9; -.
DR STRING; 9606.ENSP00000343899; -.
DR iPTMnet; Q96NE9; -.
DR PhosphoSitePlus; Q96NE9; -.
DR BioMuta; FRMD6; -.
DR DMDM; 34098678; -.
DR EPD; Q96NE9; -.
DR jPOST; Q96NE9; -.
DR MassIVE; Q96NE9; -.
DR MaxQB; Q96NE9; -.
DR PaxDb; Q96NE9; -.
DR PeptideAtlas; Q96NE9; -.
DR PRIDE; Q96NE9; -.
DR ProteomicsDB; 77504; -. [Q96NE9-1]
DR ProteomicsDB; 77505; -. [Q96NE9-2]
DR ProteomicsDB; 77506; -. [Q96NE9-3]
DR Antibodypedia; 35; 100 antibodies from 25 providers.
DR DNASU; 122786; -.
DR Ensembl; ENST00000344768.10; ENSP00000343899.6; ENSG00000139926.16. [Q96NE9-1]
DR Ensembl; ENST00000356218.8; ENSP00000348550.4; ENSG00000139926.16. [Q96NE9-2]
DR Ensembl; ENST00000395718.6; ENSP00000379068.2; ENSG00000139926.16. [Q96NE9-2]
DR Ensembl; ENST00000553556.2; ENSP00000452529.1; ENSG00000139926.16. [Q96NE9-3]
DR GeneID; 122786; -.
DR KEGG; hsa:122786; -.
DR MANE-Select; ENST00000344768.10; ENSP00000343899.6; NM_001267046.2; NP_001253975.1.
DR UCSC; uc001wzb.5; human. [Q96NE9-1]
DR CTD; 122786; -.
DR DisGeNET; 122786; -.
DR GeneCards; FRMD6; -.
DR HGNC; HGNC:19839; FRMD6.
DR HPA; ENSG00000139926; Low tissue specificity.
DR MIM; 614555; gene.
DR neXtProt; NX_Q96NE9; -.
DR OpenTargets; ENSG00000139926; -.
DR PharmGKB; PA134913028; -.
DR VEuPathDB; HostDB:ENSG00000139926; -.
DR eggNOG; KOG4371; Eukaryota.
DR GeneTree; ENSGT00940000155517; -.
DR HOGENOM; CLU_036910_1_1_1; -.
DR InParanoid; Q96NE9; -.
DR OMA; DTKPRDP; -.
DR OrthoDB; 339620at2759; -.
DR PhylomeDB; Q96NE9; -.
DR TreeFam; TF319780; -.
DR PathwayCommons; Q96NE9; -.
DR SignaLink; Q96NE9; -.
DR BioGRID-ORCS; 122786; 17 hits in 1080 CRISPR screens.
DR ChiTaRS; FRMD6; human.
DR GeneWiki; FRMD6; -.
DR GenomeRNAi; 122786; -.
DR Pharos; Q96NE9; Tbio.
DR PRO; PR:Q96NE9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q96NE9; protein.
DR Bgee; ENSG00000139926; Expressed in upper arm skin and 187 other tissues.
DR ExpressionAtlas; Q96NE9; baseline and differential.
DR Genevisible; Q96NE9; HS.
DR GO; GO:0043296; C:apical junction complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR GO; GO:0003383; P:apical constriction; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0032970; P:regulation of actin filament-based process; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13185; FERM_C_FRMD1_FRMD6; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR040179; FRMD6.
DR InterPro; IPR041781; FRMD6-FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13429:SF8; PTHR13429:SF8; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cytoplasm; Membrane; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..622
FT /note="FERM domain-containing protein 6"
FT /id="PRO_0000219448"
FT DOMAIN 16..328
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REGION 364..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 522
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C0V9"
FT MOD_RES 523
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8C0V9"
FT MOD_RES 525
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C0V9"
FT MOD_RES 542
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 544
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..358
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_008022"
FT VAR_SEQ 91..98
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005, ECO:0000303|Ref.2"
FT /id="VSP_008023"
FT CONFLICT 52
FT /note="K -> E (in Ref. 3; CAI46062)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="H -> Y (in Ref. 3; CAI46062)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 622 AA; 72044 MW; 8AE617F769B29CF6 CRC64;
MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR LKDCHLFGLS
VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI DQFGPPMIIH FRVQYYVENG
RLISDRAARY YYYWHLRKQV LHSQCVLREE AYFLLAAFAL QADLGNFKRN KHYGKYFEPE
AYFPSWVVSK RGKDYILKHI PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK
REIEASLTLG LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY ISDNLDLDMD
QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD TKPRDTGPED SYSSSAIHRK
LKTCSSMTSH GSSHTSGVES GGKDRLEEDL QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC
IYITEDMLMS RKLNGHSGLI VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR
HSLSLDDIRL YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP
VKRTSKYFSL DLTHDEVPEF VV
