FRMD6_MOUSE
ID FRMD6_MOUSE Reviewed; 622 AA.
AC Q8C0V9; Q8BW34;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=FERM domain-containing protein 6;
GN Name=Frmd6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Ovary, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 AND SER-525, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522; THR-523; SER-525 AND
RP SER-544, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96NE9}. Cell
CC membrane {ECO:0000250|UniProtKB:Q96NE9}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q96NE9}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q96NE9}. Note=Can colocalize with actin.
CC {ECO:0000250|UniProtKB:Q96NE9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8C0V9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C0V9-2; Sequence=VSP_008024, VSP_008025, VSP_008026;
CC Name=3;
CC IsoId=Q8C0V9-3; Sequence=VSP_008026, VSP_008027, VSP_008028;
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DR EMBL; AK029709; BAC26574.1; -; mRNA.
DR EMBL; AK054457; BAC35785.1; -; mRNA.
DR EMBL; BC053929; AAH53929.1; -; mRNA.
DR CCDS; CCDS25959.1; -. [Q8C0V9-1]
DR RefSeq; NP_082403.2; NM_028127.3. [Q8C0V9-1]
DR RefSeq; XP_006516040.1; XM_006515977.3. [Q8C0V9-1]
DR AlphaFoldDB; Q8C0V9; -.
DR SMR; Q8C0V9; -.
DR STRING; 10090.ENSMUSP00000052202; -.
DR iPTMnet; Q8C0V9; -.
DR PhosphoSitePlus; Q8C0V9; -.
DR EPD; Q8C0V9; -.
DR jPOST; Q8C0V9; -.
DR MaxQB; Q8C0V9; -.
DR PaxDb; Q8C0V9; -.
DR PeptideAtlas; Q8C0V9; -.
DR PRIDE; Q8C0V9; -.
DR ProteomicsDB; 271805; -. [Q8C0V9-1]
DR ProteomicsDB; 271806; -. [Q8C0V9-2]
DR ProteomicsDB; 271807; -. [Q8C0V9-3]
DR Antibodypedia; 35; 100 antibodies from 25 providers.
DR DNASU; 319710; -.
DR Ensembl; ENSMUST00000057859; ENSMUSP00000052202; ENSMUSG00000048285. [Q8C0V9-1]
DR GeneID; 319710; -.
DR KEGG; mmu:319710; -.
DR UCSC; uc007ntv.1; mouse. [Q8C0V9-1]
DR UCSC; uc007ntw.1; mouse. [Q8C0V9-3]
DR UCSC; uc007ntx.1; mouse. [Q8C0V9-2]
DR CTD; 122786; -.
DR MGI; MGI:2442579; Frmd6.
DR VEuPathDB; HostDB:ENSMUSG00000048285; -.
DR eggNOG; KOG4371; Eukaryota.
DR GeneTree; ENSGT00940000155517; -.
DR HOGENOM; CLU_036910_1_1_1; -.
DR InParanoid; Q8C0V9; -.
DR OMA; DTKPRDP; -.
DR OrthoDB; 339620at2759; -.
DR PhylomeDB; Q8C0V9; -.
DR TreeFam; TF319780; -.
DR BioGRID-ORCS; 319710; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Frmd6; mouse.
DR PRO; PR:Q8C0V9; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8C0V9; protein.
DR Bgee; ENSMUSG00000048285; Expressed in vault of skull and 237 other tissues.
DR Genevisible; Q8C0V9; MM.
DR GO; GO:0043296; C:apical junction complex; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR GO; GO:0003383; P:apical constriction; IGI:MGI.
DR GO; GO:0008104; P:protein localization; IMP:MGI.
DR GO; GO:0032970; P:regulation of actin filament-based process; IGI:MGI.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13185; FERM_C_FRMD1_FRMD6; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR040179; FRMD6.
DR InterPro; IPR041781; FRMD6-FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13429:SF8; PTHR13429:SF8; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cytoplasm; Membrane; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..622
FT /note="FERM domain-containing protein 6"
FT /id="PRO_0000219449"
FT DOMAIN 16..328
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REGION 357..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 522
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 523
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 525
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 542
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96NE9"
FT MOD_RES 544
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..22
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008024"
FT VAR_SEQ 23..33
FT /note="PNDKSVSIIIN -> MCRIPRHCCLR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008025"
FT VAR_SEQ 91..98
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008026"
FT VAR_SEQ 499..571
FT /note="LIVKEIGSSTSSSSETVVRLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRL
FT YQKDFLRIAGLCQDTAQSYTF -> ELLGQAVACRSPQAGTSKNRTVVGTLNPPGRRAT
FT AGGLIPGQVPSVEEMGEGTRVVSMFCSARFSEASSVGLI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008027"
FT VAR_SEQ 572..622
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008028"
FT CONFLICT 321
FT /note="H -> Q (in Ref. 1; BAC26574)"
FT /evidence="ECO:0000305"
FT CONFLICT 431
FT /note="G -> S (in Ref. 1; BAC35785)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 622 AA; 71652 MW; EDDC8490CD84305C CRC64;
MNKLTFHNNK AMQDRRRVCI FLPNDKSVSI IINVKILCHQ LLVQVCDLLR LKDSHLFGLS
VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI DQFGPPMIIH FRVQYYVENG
KLISDRIARY YYYWHLRKQV LHSQCVLREE AYFLLAAFAL QADLGNFKRK LHHGDYFEPE
AYFPAWVVSK RGKDYILKHI PNMHKDQFAL TASEAYLKYI KEAVRLDDVA IHYYRLYKDK
REAEGSLTLG LTMRGIQIFQ NLEEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
VYYTGCPTRS RHLLQLLSNS HRLYMNLQPV LRHLRKQEEN EEKKQYRESY ISDNLDLDMD
PLEKRSRASG SSAGSVKHKR LSRHSTASHS SSHTSGIEAD TKPRDPGPED SCSGSAMHRK
LKTCSSMTSH GSSHTSGVES GGKDRLEEDS QDEEIEMLVD DPRDLEPMPE ESLEVSPEMC
IYITEDMLLS RKLNGHSGLI VKEIGSSTSS SSETVVRLRG QSTDSLPQTI CRKPKTSTDR
HSLSLDDIRL YQKDFLRIAG LCQDTAQSYT FGCGHELDES GLYCNSCLAQ QCVNIQDAFP
VKRASKYFSL DLTHDEVPEF VV
