ID   FRMD6_RAT               Reviewed;         327 AA.
AC   Q8VII0;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=FERM domain-containing protein 6;
DE   AltName: Full=FERM domain-containing protein 163SCII;
DE   Flags: Fragment;
GN   Name=Frmd6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Gunn-Moore F.J., Tait S., Brophy P.J.;
RT   "A novel FERM containing protein sequence.";
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96NE9}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q96NE9}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q96NE9}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q96NE9}. Note=Can colocalize with actin.
CC       {ECO:0000250|UniProtKB:Q96NE9}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL32467.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF441249; AAL32467.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q8VII0; -.
DR   SMR; Q8VII0; -.
DR   STRING; 10116.ENSRNOP00000009610; -.
DR   PhosphoSitePlus; Q8VII0; -.
DR   PaxDb; Q8VII0; -.
DR   UCSC; RGD:727810; rat.
DR   RGD; 727810; Frmd6.
DR   eggNOG; KOG4371; Eukaryota.
DR   InParanoid; Q8VII0; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0043296; C:apical junction complex; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR   GO; GO:0003383; P:apical constriction; ISO:RGD.
DR   GO; GO:0032970; P:regulation of actin filament-based process; ISO:RGD.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13185; FERM_C_FRMD1_FRMD6; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR041781; FRMD6-FERM_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..>327
FT                   /note="FERM domain-containing protein 6"
FT                   /id="PRO_0000219450"
FT   DOMAIN          16..320
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   NON_TER         327
SQ   SEQUENCE   327 AA;  38847 MW;  B10D4AC1D0206086 CRC64;
     MNKLTFHNNK VMQDRRRVCI FLPNDKSVSI IINVKILCHQ LLVQVCDLLR LKDSHLFGLS
     VIQNNEHVYM ELSQKLYKYC PKEWKKEASK GIDQFGPPMI IHFRVQYYVE NGKLISDRIA
     RYYYYWHLRK QVLHSQCVLR EEAYFLLAAF ALQADLGNFK RKVHHGDYFE PEAYFPAWVV
     SKRGKDYILK HIPNMHRDQF ALTASEAYLK YIKEAVRLDD VAIHYYRLYK DKREVEGSLT
     LGLTMRGIQI FQNLEEEKQL LYDFPWTNVG KLVFVGKKFE ILPDGLPSAR KLVYYTGCPT
     RSRHLLQLLS NSHRLYMNLQ PVLRHLR