FRMD7_MOUSE
ID FRMD7_MOUSE Reviewed; 703 AA.
AC A2AD83; Q8CCP8;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=FERM domain-containing protein 7;
GN Name=Frmd7 {ECO:0000312|MGI:MGI:2686379};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:CAM15767.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC27826.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-703.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC27826.1};
RC TISSUE=Olfactory bulb {ECO:0000312|EMBL:BAC27826.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAI47258.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-703.
RC TISSUE=Brain {ECO:0000312|EMBL:AAI47258.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19892780; DOI=10.1093/hmg/ddp500;
RA Betts-Henderson J., Bartesaghi S., Crosier M., Lindsay S., Chen H.L.,
RA Salomoni P., Gottlob I., Nicotera P.;
RT "The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and
RT development.";
RL Hum. Mol. Genet. 19:342-351(2010).
CC -!- FUNCTION: Plays a role in neurite development, may be through the
CC activation of the GTPase RAC1. Plays a role in the control of eye
CC movement and gaze stability. {ECO:0000250|UniProtKB:Q6ZUT3,
CC ECO:0000269|PubMed:19892780}.
CC -!- SUBCELLULAR LOCATION: Cell projection, neuron projection
CC {ECO:0000269|PubMed:19892780}. Cell projection, growth cone
CC {ECO:0000269|PubMed:19892780}. Note=In undifferentiated neurons,
CC located in the actin-rich regions of the cell body. In differentiated
CC neurons, located in the actin-rich regions of the cell body and primary
CC neurite processes but is almost absent from secondary extensions
CC arising from the primary neurite. Also found at the actin-rich distal
CC end of growth cones. {ECO:0000269|PubMed:19892780}.
CC -!- TISSUE SPECIFICITY: In the developing cerebral cortex, strong
CC expression is observed in the ventricular and intermediate zones at 13
CC and 17 dpc. At 17 dpc and P0, expression appears to be restricted to
CC the cortical plate. In neonates, highly expressed in cortex,
CC hippocampus, cerebellum, olfactory bulb and eye with little or no
CC expression in liver, kidney, skeletal muscle or heart muscle (at
CC protein level). {ECO:0000269|PubMed:19892780}.
CC -!- INDUCTION: Up-regulated during retinoic acid-induced differentiation of
CC neuroblastoma cells. {ECO:0000269|PubMed:19892780}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI47258.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI47259.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC27826.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL670230; CAM15767.1; -; Genomic_DNA.
DR EMBL; AK032347; BAC27826.1; ALT_INIT; mRNA.
DR EMBL; BC147257; AAI47258.1; ALT_INIT; mRNA.
DR EMBL; BC147258; AAI47259.1; ALT_INIT; mRNA.
DR CCDS; CCDS53067.1; -.
DR RefSeq; NP_001177261.1; NM_001190332.1.
DR RefSeq; XP_006541568.1; XM_006541505.3.
DR RefSeq; XP_006541569.1; XM_006541506.3.
DR AlphaFoldDB; A2AD83; -.
DR SMR; A2AD83; -.
DR STRING; 10090.ENSMUSP00000057103; -.
DR iPTMnet; A2AD83; -.
DR PhosphoSitePlus; A2AD83; -.
DR PaxDb; A2AD83; -.
DR PRIDE; A2AD83; -.
DR ProteomicsDB; 271808; -.
DR Antibodypedia; 430; 107 antibodies from 15 providers.
DR Ensembl; ENSMUST00000060650; ENSMUSP00000057103; ENSMUSG00000036131.
DR GeneID; 385354; -.
DR KEGG; mmu:385354; -.
DR UCSC; uc012hgz.1; mouse.
DR CTD; 90167; -.
DR MGI; MGI:2686379; Frmd7.
DR VEuPathDB; HostDB:ENSMUSG00000036131; -.
DR eggNOG; KOG3529; Eukaryota.
DR eggNOG; KOG3531; Eukaryota.
DR GeneTree; ENSGT00940000158972; -.
DR HOGENOM; CLU_030239_0_0_1; -.
DR InParanoid; A2AD83; -.
DR OMA; ERPDSCL; -.
DR OrthoDB; 476668at2759; -.
DR PhylomeDB; A2AD83; -.
DR TreeFam; TF317513; -.
DR BioGRID-ORCS; 385354; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Frmd7; mouse.
DR PRO; PR:A2AD83; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2AD83; protein.
DR Bgee; ENSMUSG00000036131; Expressed in olfactory bulb and 25 other tissues.
DR ExpressionAtlas; A2AD83; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0030426; C:growth cone; IDA:UniProtKB.
DR GO; GO:0043005; C:neuron projection; IDA:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0032091; P:negative regulation of protein binding; IDA:MGI.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IDA:MGI.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0010592; P:positive regulation of lamellipodium assembly; IDA:MGI.
DR GO; GO:0051057; P:positive regulation of small GTPase mediated signal transduction; IGI:MGI.
DR GO; GO:0010975; P:regulation of neuron projection development; IMP:UniProtKB.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014847; FERM-adjacent.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 1: Evidence at protein level;
KW Cell projection; Coiled coil; Neurogenesis; Reference proteome.
FT CHAIN 1..703
FT /note="FERM domain-containing protein 7"
FT /id="PRO_0000391462"
FT DOMAIN 2..282
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT COILED 525..552
FT /evidence="ECO:0000255"
SQ SEQUENCE 703 AA; 80330 MW; 4D964A61B041F0C0 CRC64;
MLHLKVQFLD DSQKIFVVDQ KSSGKALFNL SCGHLNLAEK EYFGLEFCSH SGNNVWLELL
KPITKQVKNP KEVVFKFMVK FFPVDPGHLR EELTRYLFTL QIKKDLALGR LPCSDNCTAL
MVSHILQSEL GDFHEETVRK HLVQTQYLPS QASLESKIMQ FHQQHIGRSP AESDILLLDI
ARKLDMYGIR PQPASDGEGM QIHLAVAHMG VLVLRGNTKI NTFNWAKIRK LSFKRKHFLI
KLHANILVLC KDTLEFTMAS RDACKAFWKT CVEYHAFFRL SEEPKSKPKT LLCSKGSSFR
YSGRTQRQLL EYGKKGRLKS LPFERKQYPS QYHERQCRSS PDILSDVSKQ VEDLRLTYGS
SYYRNVNGVH ASESMLDSRR RNSAVEVTFA AELEHSKPEA EATSLHPSQS SSSFTFIYAD
PVFNTDPEPI EFFEERSPLS SFQTTSKFAD SHTSKASPAR QLTYTDVPYI PCTSQKVDIM
PPQVFFYVDK PPQVPRRSLI MAEENMRPDS YVDHSAIKPA KRSPRNMRIK SLQQDLQELQ
EAMARTSGRS NINVEPEEED PHLDDAFAYN LQEQTPKRSQ SQSDMKTIRF PFGSEFRPLG
PCPALTRKTD LFACTFAEQE FPTVLIDQSS AERYVASESS DSESEIIKPD YYFLYGKGTK
SPRARIRLSS GSLQLEEEDE TISFATPGAE DRTLLKPCNY FLA
