FRMD8_DANRE
ID FRMD8_DANRE Reviewed; 471 AA.
AC E7F221;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=FERM domain-containing protein 8;
DE AltName: Full=Band4.1 inhibitor LRP interactor {ECO:0000303|PubMed:19572019};
DE Short=Bili {ECO:0000303|PubMed:19572019};
GN Name=frmd8;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=19572019; DOI=10.1371/journal.pone.0006129;
RA Kategaya L.S., Changkakoty B., Biechele T., Conrad W.H., Kaykas A.,
RA Dasgupta R., Moon R.T.;
RT "Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of
RT axin to LRP6.";
RL PLoS ONE 4:E6129-E6129(2009).
CC -!- FUNCTION: Promotes the cell surface stability of rhomboid 5 homologs
CC and prevents their degradation via the endolysosomal pathway. By acting
CC on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By
CC similarity). Negatively regulates the Wnt/beta-catenin signaling
CC pathway (PubMed:19572019). {ECO:0000250|UniProtKB:Q9BZ67,
CC ECO:0000269|PubMed:19572019}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9BZ67}. Cell membrane
CC {ECO:0000250|UniProtKB:Q9BZ67}.
CC -!- DEVELOPMENTAL STAGE: Maternally expressed transcript, detected in the
CC animal pole at 4 hpf. At 5.5 hpf, widely expressed at 50% epiboly. At
CC 24 hpf, widely expressed, with high levels in the otic vesicle. At 36
CC hpf, weak expression in the tail. {ECO:0000269|PubMed:19572019}.
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DR EMBL; CR450793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_687842.2; XM_682750.8.
DR AlphaFoldDB; E7F221; -.
DR SMR; E7F221; -.
DR STRING; 7955.ENSDARP00000115626; -.
DR PaxDb; E7F221; -.
DR PeptideAtlas; E7F221; -.
DR Ensembl; ENSDART00000135493; ENSDARP00000115626; ENSDARG00000073696.
DR Ensembl; ENSDART00000192148; ENSDARP00000155247; ENSDARG00000073696.
DR GeneID; 559410; -.
DR KEGG; dre:559410; -.
DR CTD; 83786; -.
DR ZFIN; ZDB-GENE-090812-5; frmd8.
DR eggNOG; KOG4335; Eukaryota.
DR GeneTree; ENSGT00530000063721; -.
DR HOGENOM; CLU_032351_0_0_1; -.
DR InParanoid; E7F221; -.
DR OMA; GSHYRAY; -.
DR OrthoDB; 1068540at2759; -.
DR PhylomeDB; E7F221; -.
DR TreeFam; TF317921; -.
DR PRO; PR:E7F221; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 10.
DR Bgee; ENSDARG00000073696; Expressed in swim bladder and 30 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:ZFIN.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IGI:ZFIN.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IGI:ZFIN.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR Pfam; PF00373; FERM_M; 1.
DR SMART; SM00295; B41; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..471
FT /note="FERM domain-containing protein 8"
FT /id="PRO_0000447189"
FT DOMAIN 31..382
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 52227 MW; 9025B1C5461C6756 CRC64;
MEGDDGDFPP EPSEHSLSQR GSVASSVTRA QDLLVYLAND SAVHLTLEGL GCMNAQELGR
SVREALNIPN SAADVFAFWF CSPLLELQLK PKHLPYKLCR QWQDLLYRFT EAPTEDISLD
EPSLLFKRSV FYPRAKELQI EDEGVLRLLY DEAKMNILEG RYPCDPEHWL TLGALSCAIE
LGTELDDQAL TAAIREKKLS SFLPAHAALG GGGFLSTLRG RGGRNAEMEQ NLVKECRSVC
SSAASGSSQE PIALLRQYLR SCHNLPYYGC AFFAGEIDKP AQGLLHRGGR KAVSVGISLE
GVYVMDVKEK HVLLGLKFTE LSWDHSYPET EGDSHILWLE FDGEEAGTPV NKLLKIYSKQ
AELMSGLIEF CVELRSVSES AATGTDGEVT PSHEPTSPET NNKTRERRQG KLRRQNSVVC
SRVHSLSTIN YVDDGKEIKR LKPKRAASFF TRQAQPPTYS AVQVTESLEQ G
