ID   FRMD8_XENLA             Reviewed;         452 AA.
AC   Q7ZWP1;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=FERM domain-containing protein 8;
GN   Name=frmd8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes the cell surface stability of RHBDF1 and RHBDF2 and
CC       prevents their degradation via the endolysosomal pathway. By acting on
CC       RHBDF proteins, involved in ADAM17-mediated ligand shedding (By
CC       similarity). May negatively regulate Wnt signaling (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BZ67}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9BZ67}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9BZ67}.
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DR   EMBL; BC046857; AAH46857.1; -; mRNA.
DR   RefSeq; NP_001079676.1; NM_001086207.1.
DR   AlphaFoldDB; Q7ZWP1; -.
DR   SMR; Q7ZWP1; -.
DR   BioGRID; 97606; 1.
DR   IntAct; Q7ZWP1; 1.
DR   MaxQB; Q7ZWP1; -.
DR   DNASU; 379363; -.
DR   GeneID; 379363; -.
DR   KEGG; xla:379363; -.
DR   CTD; 379363; -.
DR   Xenbase; XB-GENE-6079145; frmd8.L.
DR   OMA; GSHYRAY; -.
DR   OrthoDB; 1068540at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 379363; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF00373; FERM_M; 1.
DR   SMART; SM00295; B41; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..452
FT                   /note="FERM domain-containing protein 8"
FT                   /id="PRO_0000295781"
FT   DOMAIN          28..374
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          373..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   452 AA;  51584 MW;  EA308F4DB77FD186 CRC64;
     MDGSETSHSS GLNDFLLRSS VSSGSRSMDV IIYLINDEVI QLTVDGLSVI TAHELHKSIR
     EALQLPETAQ DVFALWLISP LLEVQLKPKH QPYKVCRQWH DLLARFTNCS SNDILQDEPY
     LQFRRNIFLP KARELQISHE RILYLLYEEA KYNVLEGRYP CDVEDCEVLG GLACRLELGP
     YNQNEHTPAT IRPKLDTLFP PYLCKKRNGG LLTTFKNRGG RQASFEQTVL NTYKEVKETS
     ACTDEQAMKN HYKEYLKKCH ELPYYGCAFF QGDVDKPAQG FLNRSGRKAV SVSVNLEGVS
     VIDRKEKHVL ISLTYPELSW DHTYPDEDEH ILWLEFDGES EGTPVNKLLK IYSKQAELMS
     GLIEYCIELS QSTESPASDS TPGNSQLSEK RSKLKRQESV LCNRMKHLTT IDYVEDGAKI
     TRVKPKRTAS FFTRQNTHNY SAVQPSETPT ES