ID   FRMD8_XENTR             Reviewed;         450 AA.
AC   Q0IJ35; Q4KMW0;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=FERM domain-containing protein 8;
GN   Name=frmd8;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes the cell surface stability of RHBDF1 and RHBDF2 and
CC       prevents their degradation via the endolysosomal pathway. By acting on
CC       RHBDF proteins, involved in ADAM17-mediated ligand shedding (By
CC       similarity). May negatively regulate Wnt signaling (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BZ67}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9BZ67}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9BZ67}.
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DR   EMBL; BC098323; AAH98323.1; -; mRNA.
DR   EMBL; BC121203; AAI21204.1; -; mRNA.
DR   RefSeq; NP_001072175.1; NM_001078707.1.
DR   RefSeq; XP_012816683.1; XM_012961229.2.
DR   AlphaFoldDB; Q0IJ35; -.
DR   SMR; Q0IJ35; -.
DR   STRING; 8364.ENSXETP00000050012; -.
DR   PaxDb; Q0IJ35; -.
DR   DNASU; 613069; -.
DR   GeneID; 613069; -.
DR   KEGG; xtr:613069; -.
DR   CTD; 83786; -.
DR   Xenbase; XB-GENE-5852953; frmd8.
DR   eggNOG; KOG4335; Eukaryota.
DR   HOGENOM; CLU_032351_0_0_1; -.
DR   InParanoid; Q0IJ35; -.
DR   OrthoDB; 1068540at2759; -.
DR   PhylomeDB; Q0IJ35; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF00373; FERM_M; 1.
DR   SMART; SM00295; B41; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..450
FT                   /note="FERM domain-containing protein 8"
FT                   /id="PRO_0000295782"
FT   DOMAIN          28..373
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
SQ   SEQUENCE   450 AA;  51634 MW;  F52200A5F0543B1D CRC64;
     MDGSETSHSS GLNDFLLRSS VSSGSRSMDV IVYLINDEII QLTVDGLSVI TAHELHKSIR
     EALQLPETAQ DVFALWLISP FLEVQLKPKH QPYKVCRQWH DLLARFTNCS SNDILQDEPF
     LQFRRNIFFP KARELQIAHE RTLYLLYEEA KYNVLDGRYP CDVEDCELLG GLACRLELGP
     YNQNEHTPAT IRPKLDSLFP PYLCKKRNGF FTTFKNKGGR QASFEQTVLN TYKEVKESSA
     CTEEQAMKNH YREYLKKCHE LPYYGCAFFH GVVDKPAQGF LNRSGRKPVS VAINLEGVSV
     IDRKEKHILI SLTYPELSWD HTYPDEEEHI LWLEFDGDAE GTPVNKLLKI YSKQAELMSG
     LIEYCIELSQ TTESPASDFL PGNSQLSEKR SKLRRQESVL CNRMKHLNTI DYVEDGASIK
     RVKPKRTASF FTRQNTHYSA VQPSETPTET