ID   FRMR_ECOLI              Reviewed;          91 AA.
AC   P0AAP3; P55756; P77584; Q2MC67;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Transcriptional repressor FrmR;
GN   Name=frmR; Synonyms=yaiN; OrderedLocusNames=b0357, JW0348;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=8808933; DOI=10.1128/jb.178.18.5438-5446.1996;
RA   van der Ploeg J.R., Weiss M.A., Saller E., Nashimoto H., Saito N.,
RA   Kertesz M.A., Leisinger T.;
RT   "Identification of sulfate starvation-regulated genes in Escherichia coli:
RT   a gene cluster involved in the utilization of taurine as a sulfur source.";
RL   J. Bacteriol. 178:5438-5446(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   FUNCTION AS A REPRESSOR, AND INDUCTION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15466022; DOI=10.1128/jb.186.20.6714-6720.2004;
RA   Herring C.D., Blattner F.R.;
RT   "Global transcriptional effects of a suppressor tRNA and the inactivation
RT   of the regulator frmR.";
RL   J. Bacteriol. 186:6714-6720(2004).
CC   -!- FUNCTION: Repressor of the frmRAB operon.
CC       {ECO:0000269|PubMed:15466022}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Induced by formaldehyde. Negatively autoregulated.
CC       {ECO:0000269|PubMed:15466022}.
CC   -!- SIMILARITY: Belongs to the FrmR/RcnR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB18082.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=D85613; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; D85613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U73857; AAB18082.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC73460.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76139.1; -; Genomic_DNA.
DR   RefSeq; NP_414891.4; NC_000913.3.
DR   RefSeq; WP_001141271.1; NZ_STEB01000036.1.
DR   PDB; 5LBM; X-ray; 2.70 A; A/B/C/D=1-91.
DR   PDBsum; 5LBM; -.
DR   AlphaFoldDB; P0AAP3; -.
DR   SMR; P0AAP3; -.
DR   BioGRID; 4261804; 13.
DR   DIP; DIP-48245N; -.
DR   IntAct; P0AAP3; 2.
DR   STRING; 511145.b0357; -.
DR   jPOST; P0AAP3; -.
DR   PaxDb; P0AAP3; -.
DR   PRIDE; P0AAP3; -.
DR   EnsemblBacteria; AAC73460; AAC73460; b0357.
DR   EnsemblBacteria; BAE76139; BAE76139; BAE76139.
DR   GeneID; 67416561; -.
DR   GeneID; 944986; -.
DR   KEGG; ecj:JW0348; -.
DR   KEGG; eco:b0357; -.
DR   PATRIC; fig|1411691.4.peg.1921; -.
DR   EchoBASE; EB3081; -.
DR   eggNOG; COG1937; Bacteria.
DR   HOGENOM; CLU_130332_3_0_6; -.
DR   InParanoid; P0AAP3; -.
DR   OMA; DCGPILQ; -.
DR   PhylomeDB; P0AAP3; -.
DR   BioCyc; EcoCyc:G6209-MON; -.
DR   PRO; PR:P0AAP3; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR   Gene3D; 1.20.58.1000; -; 1.
DR   InterPro; IPR003735; Metal_Tscrpt_repr.
DR   InterPro; IPR038390; Metal_Tscrpt_repr_sf.
DR   PANTHER; PTHR33677; PTHR33677; 1.
DR   Pfam; PF02583; Trns_repr_metal; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..91
FT                   /note="Transcriptional repressor FrmR"
FT                   /id="PRO_0000168591"
SQ   SEQUENCE   91 AA;  10318 MW;  23305017AAB2C22D CRC64;
     MPSTPEEKKK VLTRVRRIRG QIDALERSLE GDAECRAILQ QIAAVRGAAN GLMAEVLESH
     IRETFDRNDC YSREVSQSVD DTIELVRAYL K