ID   FRP1_PROCL              Reviewed;          76 AA.
AC   Q867W1;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=FMRFamide-related neuropeptides;
DE   Contains:
DE     RecName: Full=GYRKPPFNGSIF-amide;
DE              Short=SIFamide;
DE   Contains:
DE     RecName: Full=C-terminal peptide;
DE   Flags: Precursor;
OS   Procambarus clarkii (Red swamp crayfish).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Cambaridae; Procambarus.
OX   NCBI_TaxID=6728;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAC55939.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-39, AMIDATION AT PHE-39,
RP   FUNCTION, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=14723891; DOI=10.1016/j.ygcen.2003.10.001;
RA   Yasuda A., Yasuda-Kamatani Y., Nozaki M., Nakajima T.;
RT   "Identification of GYRKPPFNGSIFamide (crustacean-SIFamide) in the crayfish
RT   Procambarus clarkii by topological mass spectrometry analysis.";
RL   Gen. Comp. Endocrinol. 135:391-400(2004).
CC   -!- FUNCTION: GYRKPPFNGSIF-amide may be involved in olfaction and
CC       contraction of hindgut. {ECO:0000269|PubMed:14723891}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Olfactory lobe and accessory lobe, olfactory
CC       globular tract, olfactory lobe cells (at protein level). Widely
CC       distributed throughout nervous system. {ECO:0000269|PubMed:14723891}.
CC   -!- MASS SPECTROMETRY: [GYRKPPFNGSIF-amide]: Mass=1381; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:14723891};
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000255}.
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DR   EMBL; AB036712; BAC55939.1; -; mRNA.
DR   EMBL; AB036713; BAC55940.1; -; mRNA.
DR   AlphaFoldDB; Q867W1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000269|PubMed:14723891"
FT   PEPTIDE         28..39
FT                   /note="GYRKPPFNGSIF-amide"
FT                   /evidence="ECO:0000269|PubMed:14723891"
FT                   /id="PRO_0000253935"
FT   PEPTIDE         43..74
FT                   /note="C-terminal peptide"
FT                   /evidence="ECO:0000255, ECO:0000303|PubMed:14723891"
FT                   /id="PRO_0000253936"
FT   MOD_RES         39
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:14723891"
SQ   SEQUENCE   76 AA;  7895 MW;  3A3DF225947483AA CRC64;
     MCVQTRMLVA VAVVLVVLAV LSDPVSAGYR KPPFNGSIFG KRAGGDSLYE PGKALASACQ
     VAVEACAAWF PGPEKK