FRP2L_HUMAN
ID FRP2L_HUMAN Reviewed; 320 AA.
AC Q6IN97; B2RPG2; Q5RJ30;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Putative protein FRMPD2-like {ECO:0000305};
DE AltName: Full=FERM and PDZ domain-containing protein 2 pseudogene 1 {ECO:0000312|HGNC:HGNC:16843};
DE AltName: Full=FERM and PDZ domain-containing protein 2B pseudogene {ECO:0000312|HGNC:HGNC:16843};
DE AltName: Full=PDZ domain-containing protein 5A {ECO:0000312|HGNC:HGNC:16843};
GN Name=FRMPD2B {ECO:0000312|HGNC:HGNC:16843};
GN Synonyms=FRMPD2L1, FRMPD2L2, FRMPD2P1, FRMPD2P2, PDZD5A, PDZD5B, PDZK5A,
GN PDZK5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CAUTION: Could be the product of a pseudogene. This is the product of
CC related genes or pseudogenes located in a region of chromosome 10q
CC which contains a segmental duplication resulting in three nearly
CC identical regions. {ECO:0000305}.
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DR EMBL; AK294650; BAG57825.1; -; mRNA.
DR EMBL; AK315971; BAH14342.1; -; mRNA.
DR EMBL; AL450334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX005072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC071635; AAH71635.1; -; mRNA.
DR EMBL; BC072395; AAH72395.1; -; mRNA.
DR EMBL; BC110798; AAI10799.1; -; mRNA.
DR EMBL; BC137431; AAI37432.1; -; mRNA.
DR EMBL; BC137434; AAI37435.1; -; mRNA.
DR EMBL; BC137439; AAI37440.1; -; mRNA.
DR EMBL; BC137440; AAI37441.1; -; mRNA.
DR AlphaFoldDB; Q6IN97; -.
DR SMR; Q6IN97; -.
DR BioMuta; HGNC:16843; -.
DR DMDM; 74757975; -.
DR MassIVE; Q6IN97; -.
DR PeptideAtlas; Q6IN97; -.
DR PRIDE; Q6IN97; -.
DR GeneCards; FRMPD2B; -.
DR HGNC; HGNC:16843; FRMPD2B.
DR neXtProt; NX_Q6IN97; -.
DR InParanoid; Q6IN97; -.
DR PhylomeDB; Q6IN97; -.
DR Pharos; Q6IN97; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6IN97; protein.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR029906; FRMPD2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR19964:SF56; PTHR19964:SF56; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 5: Uncertain;
KW Reference proteome; Repeat.
FT CHAIN 1..320
FT /note="Putative protein FRMPD2-like"
FT /id="PRO_0000306855"
FT DOMAIN 1..46
FT /note="PDZ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 90..178
FT /note="PDZ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 215..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 35161 MW; CB4F3517710A7C99 CRC64;
MTSIPFPGDR LLQVDGVILC GLTHKQAVQC LKGPGQVARL VLERRVPRST QQCPSANDSM
GDERTAVSLV TALPGRPSSC VSVTDGPKFE VKLKKNANGL GFSFVQMEKE SCSHLKSDLV
RIKRLFPGQP AEENGAIAAG DIILAVNGRS TEGLIFQEVL HLLRGAPQEV TLLLCRPPPG
ALPEMEQEWQ TPELSADKEF TRATCTDSCT SPILDQEDSW RDSASPDAGE GLGLRPESSQ
KAIREAQWGQ NRERPWASSL THSPESHPHL CKLHQERDES TLATSLEKDV RQNCYSVCDI
MRLGRYSFSS PLTRLSTDIF
