ID   FRPA_NEIMC              Reviewed;        1115 AA.
AC   P55126;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Iron-regulated protein FrpA;
GN   Name=frpA;
OS   Neisseria meningitidis serogroup C.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=135720;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FAM20 / Serogroup C;
RX   PubMed=8423153; DOI=10.1128/jb.175.3.811-818.1993;
RA   Thompson S.A., Wang L.L., West A., Sparling P.F.;
RT   "Neisseria meningitidis produces iron-regulated proteins related to the RTX
RT   family of exoproteins.";
RL   J. Bacteriol. 175:811-818(1993).
CC   -!- FUNCTION: May participate in the pathogenesis of meningococcal disease.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Peripheral membrane protein.
CC       Secreted.
CC   -!- DOMAIN: The Gly-rich region is probably involved in binding calcium,
CC       which is required for target cell-binding or cytolytic activity.
CC   -!- SIMILARITY: Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
CC       {ECO:0000305}.
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DR   EMBL; L06302; AAA25454.1; -; Genomic_DNA.
DR   PIR; A47058; A47058.
DR   AlphaFoldDB; P55126; -.
DR   SMR; P55126; -.
DR   PRIDE; P55126; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.150.10.10; -; 3.
DR   InterPro; IPR010566; Haemolys_ca-bd.
DR   InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR   InterPro; IPR001343; Hemolysn_Ca-bd.
DR   InterPro; IPR003995; RTX_toxin_determinant-A.
DR   InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR   Pfam; PF06594; HCBP_related; 2.
DR   Pfam; PF00353; HemolysinCabind; 3.
DR   PRINTS; PR01488; RTXTOXINA.
DR   SUPFAM; SSF51120; SSF51120; 2.
DR   PROSITE; PS00330; HEMOLYSIN_CALCIUM; 5.
PE   3: Inferred from homology;
KW   Calcium; Cell outer membrane; Membrane; Repeat; Secreted; Toxin; Virulence.
FT   CHAIN           1..1115
FT                   /note="Iron-regulated protein FrpA"
FT                   /id="PRO_0000196243"
FT   REPEAT          755..772
FT                   /note="Hemolysin-type calcium-binding 1"
FT   REPEAT          773..790
FT                   /note="Hemolysin-type calcium-binding 2"
FT   REPEAT          901..918
FT                   /note="Hemolysin-type calcium-binding 3"
FT   REPEAT          919..936
FT                   /note="Hemolysin-type calcium-binding 4"
FT   REPEAT          937..954
FT                   /note="Hemolysin-type calcium-binding 5"
FT   REPEAT          955..972
FT                   /note="Hemolysin-type calcium-binding 6"
FT   REPEAT          973..990
FT                   /note="Hemolysin-type calcium-binding 7"
SQ   SEQUENCE   1115 AA;  122178 MW;  21841065BCCACEFA CRC64;
     MTSANFNING FGDVKLTPYS PLLGYKAWDS FIGSIQSLSD LIYNVDNNRN KMEITVNNAI
     QAADSFLSSI GRDNKITNTA SLLASLDNIF LNLRNVSRDI RETGKFKPND IQQAIGDIFI
     AAGDGLQYIK QQTEAMAQSK FLPTKLKTGL NDVLNSRMLK SSTVLQHELN YLGFKIKDYG
     NERLGESIMN IDDFTPSKIA NFFADPDTYS NVLEEVSRFI YSLVPDDANP WKGGEDYIGR
     GISEWGELLE KWYKQDFLPY LEKEWDQFPK FEDWLPEFPE WAREWLKLDP KRSGKYHVYD
     PLALDLDGDG IETVAAKGFA GALFDHRNQG IRTATGWVSA DDGLLVRDLN GNGIIDNGAE
     LFGDNTKLAD GSFAKHGYAA LAELDSNGDN IINAADAAFQ TLRVWQDLNQ DGISQANELR
     TLEELGIQSL DLAYKDVNKN LGNGNTLAQQ GSYTKTDGTT AKMGDLLLAA DNLHSRFKDK
     VELTAEQAKA ANLAGIGRLR DLREAAALSG DLANMLKAYS AAETKEAQLA LLDNLIHKWA
     ETDSNWGKKS PMRLSTDWTQ TANEGIALTP SQVAQLKKNA LVSLSDKAKA AIDAARDRIA
     VLDAYTGQDS STLYYMSEED ALNIVKVTND TYDHLAKNIY QNLLFQTRLQ PYLNQISFKM
     ENDTFTLDFS GLVQAFNHVK ETNPQKAFVD LAEMLAYGEL RSWYEGRRLM ADYVEEAKKA
     GKFEDYQKVL GQETVALLAK TSGTQADDIL QNVGFGHNKN VSLYGNDGND TLIGGAGNDY
     LEGGSGSDTY VFGKGFGQDT VYNYDYATGR KDIIRFTDGI TADMLTFTRE GNHLLIKAKD
     DSGQVTVQSY FQNDGSGAYR IDEIHFDNGK VLDVATVKEL VQQSTDGSDR LYAYQSGSTL
     NGGLGDDYLY GADGNDLLNG DAGNDSIYSG NGNDTLDGGE GNDALYGYNG NDALNGGEGN
     DHLNGEDGND TLIGGAGNDY LEGGSGSDTY VFGEGFGQDT VYNYHVDKNS DTMHFKGFKA
     ADVHFIRSGS DLVLSASEQD NVRISGFFYG ENHRVDTFVF DDAAISNPDF AKYINAGNNL
     VQSMSVFGSN TAATGGNVDA NIQSVQQPLL VTPSA