FRPD3_HUMAN
ID FRPD3_HUMAN Reviewed; 1810 AA.
AC Q5JV73; Q96JK8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=FERM and PDZ domain-containing protein 3;
GN Name=FRMPD3; Synonyms=KIAA1817;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 814-1810.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
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DR EMBL; AL035088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL137787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB058720; BAB47446.1; -; mRNA.
DR CCDS; CCDS76006.1; -.
DR RefSeq; NP_115804.1; NM_032428.1.
DR AlphaFoldDB; Q5JV73; -.
DR SMR; Q5JV73; -.
DR BioGRID; 124081; 1.
DR IntAct; Q5JV73; 1.
DR STRING; 9606.ENSP00000276185; -.
DR iPTMnet; Q5JV73; -.
DR PhosphoSitePlus; Q5JV73; -.
DR BioMuta; FRMPD3; -.
DR DMDM; 118582027; -.
DR EPD; Q5JV73; -.
DR jPOST; Q5JV73; -.
DR MassIVE; Q5JV73; -.
DR MaxQB; Q5JV73; -.
DR PaxDb; Q5JV73; -.
DR PeptideAtlas; Q5JV73; -.
DR PRIDE; Q5JV73; -.
DR ProteomicsDB; 63310; -.
DR Antibodypedia; 572; 47 antibodies from 21 providers.
DR DNASU; 84443; -.
DR Ensembl; ENST00000276185.9; ENSP00000276185.5; ENSG00000147234.11.
DR GeneID; 84443; -.
DR KEGG; hsa:84443; -.
DR UCSC; uc033eqj.1; human.
DR CTD; 84443; -.
DR GeneCards; FRMPD3; -.
DR HGNC; HGNC:29382; FRMPD3.
DR HPA; ENSG00000147234; Tissue enhanced (brain, ovary, thyroid gland).
DR MIM; 301005; gene.
DR neXtProt; NX_Q5JV73; -.
DR PharmGKB; PA143485474; -.
DR VEuPathDB; HostDB:ENSG00000147234; -.
DR eggNOG; KOG3552; Eukaryota.
DR InParanoid; Q5JV73; -.
DR OMA; TDCMGAP; -.
DR OrthoDB; 24326at2759; -.
DR PhylomeDB; Q5JV73; -.
DR TreeFam; TF316497; -.
DR PathwayCommons; Q5JV73; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q5JV73; -.
DR BioGRID-ORCS; 84443; 3 hits in 204 CRISPR screens.
DR ChiTaRS; FRMPD3; human.
DR GenomeRNAi; 84443; -.
DR Pharos; Q5JV73; Tdark.
DR PRO; PR:Q5JV73; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JV73; protein.
DR Bgee; ENSG00000147234; Expressed in right hemisphere of cerebellum and 95 other tissues.
DR ExpressionAtlas; Q5JV73; baseline and differential.
DR Genevisible; Q5JV73; HS.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0030667; C:secretory granule membrane; TAS:Reactome.
DR GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13183; FERM_C_FRMPD1_FRMPD3_FRMPD4; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041779; FRMPD1/3/4_FERM_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..1810
FT /note="FERM and PDZ domain-containing protein 3"
FT /id="PRO_0000254650"
FT DOMAIN 54..131
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 180..494
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REGION 524..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1342..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1765..1798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 814..822
FT /note="DMSEMMSAM -> ALKSWFHDL (in Ref. 2; BAB47446)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1810 AA; 199209 MW; 9FC42A38E6B682BB CRC64;
METLDSQRVQ DRLLAAPGCS SPSGQQELFS SHVMQEESAN DMECEQLPAE ILRQVTVHRD
PIYGFGFVAG SERPVVVRSV RPGGPSENKL LAGDQIVAIN EEDVSEAPRE RLIELIRSAK
EFIVLTVLHT HQSPKSAFIS AAKKAKLRSN PVKVRFSEQV AVGETDAKMM KKEALLLIPN
VLKVFLENGQ IKSFTFDGRT TVKDVMLTLQ DRLSLRFIEH FALVLEYAGP EQNHKFLLLQ
DKQPLAYVVQ RTHYHGMKCL FRISFFPKDP VELLRRDPAA FEYLYIQSRN DVIRERFGMD
PKPEMLLGLA ALHIYITVSA TRPSQKISLK NVEKEWGLEP FLPPSLLQVI KEKNLRKSLS
QQLKAHQTHP SCGTKGSAIQ AKLQYLRILN ELPTFTGVLF NTVGLDEKQS ATTLLVGPRH
GISHVIDLKT NLTTVLSEFS KISKIQLFRE NQGVARVETS IMDAKPLVLL MEWPEATNFA
CLIAGYCRLL LDSRKMVFSR PASQPLPPPM IKADYMHSAH RPVTGGHLGK KESSYVGSVG
TSPRKSSRCT PPPADSELVS FCYLHMREQR KEQESRTDVN ENLIFFEETR PRTKSDPTSK
SSGQGYEVVP DDFDAASLDH EPCASRARSY TLDNSLGAEA LNFYCDSCKA KLQEQLGPRK
GGKPGSSRDN IVDLMSLPPP GSEEEEEEED ETTSLLPAIA APPPGFRDNS SDEDDPKRRA
VQSQEQGRHL RGLLYDEIPV TLIDSVQTRT VRDHAQELDD ALVSTLQALE ALAASEDGPH
PPPPQTAGLI VLATITPESS LDSGHETNSS ELTDMSEMMS AMKQHQNTTY FLAQHLNKDS
LLARKDLPFR IQSCAAQAVL TAPYSLGRPD PNPSLQPIAT GQSPGPPGAR RKLPQSEGQV
QGERTYSLAV HPALSPQLSE QKNLSLLSPV PEDKGPGHTR AGLEMSLRAA TSSLSEEQVS
ELRDNLPKEV RLSPKLILDP KSSVTPAIIS AALQQVVHNK SLVTAGGALG NPPSRGERRL
EASMGRPEVS MMSSSASKNL KFKISPSAPE TSWNSQHQLG AEVSSSPRAP TGSRADSLHL
SQQEDSLPVQ NFPPKSYLLR TSRESVGKQA TGEVAGKGGP VGGKPTLQKQ GTISSQGEKA
QLESTPKRSK LEETSLVPRA TYPMALQSPS CQSRSHSPSC QPHGHSPSSQ SRGQSPSCQP
RGQSPLRSQA ASRQVSTMPS RKLETTLNGA HSTSEGPAKP KSSRGPFRLR NLFSATFPTR
QKKETDERQA QLQKVKQYEL EFLEELLKPP SQGELPGTEY LQPPAPGRCS CQLRSSPVQQ
GPGMSREQRR SCDCKRICRG GRPQATQTPV PSLRGRERDR VLPSQRQPEA GPGVSLSSPI
NVQRIRSTSL ESRECRSDPE SGVSCLTTCA SGGECLGAPN YRKLMRRYSI SELDQGDRAS
LTSDVYPHPP LGMLPREAKE VEASLPIALG PKSRSLESPT LGDPSYVQVA PETKGPRQMA
VFSLPEEVYR KPAELDEDSE SSKCCSIRYC FYYRKCDMAD DASDGKDELS YSIPMKILPG
MKLDEQVVPV VSRTLQVLDA ATCSSSSPEA SRTQEIDLRV STFEGSLAKI NALRAHAYGL
PDGFLAARLD TNELLTVLRQ CVASPEARAP KPYVSQISEY KLELALKFKE LRASCRRVAN
VDKSPTHMLA AITGSFQVLS SLIETFVRLV FIVRSEAQRQ ELLAKVEEVV RNYTFLLRAA
EESTARNLNQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQVAAA AGAATEHPPG SPTSATVMST
FTHSLKTLIK
