ID   ALDH_DEIRA              Reviewed;         515 AA.
AC   Q9RYG9; O32502;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Aldehyde dehydrogenase;
DE            EC=1.2.1.3;
GN   Name=aldA; OrderedLocusNames=DR_A0348;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-258.
RC   STRAIN=KD8301;
RA   Narumi I., Du Z., Alatas Z., Kitayama S., Watanabe H.;
RT   "Isolation and characterization of pprA, a novel Deinococcus radiodurans
RT   gene involved in DNA repair.";
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; AE001825; AAF12436.1; -; Genomic_DNA.
DR   EMBL; AB003475; BAA21372.1; -; Genomic_DNA.
DR   PIR; H75589; H75589.
DR   RefSeq; NP_285671.1; NC_001264.1.
DR   RefSeq; WP_010889607.1; NZ_CP015082.1.
DR   AlphaFoldDB; Q9RYG9; -.
DR   SMR; Q9RYG9; -.
DR   STRING; 243230.DR_A0348; -.
DR   PRIDE; Q9RYG9; -.
DR   EnsemblBacteria; AAF12436; AAF12436; DR_A0348.
DR   KEGG; dra:DR_A0348; -.
DR   PATRIC; fig|243230.17.peg.3240; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_0_2_0; -.
DR   InParanoid; Q9RYG9; -.
DR   OMA; HGIGYYP; -.
DR   OrthoDB; 744602at2; -.
DR   Proteomes; UP000002524; Chromosome II.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..515
FT                   /note="Aldehyde dehydrogenase"
FT                   /id="PRO_0000056447"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        272
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        311
FT                   /evidence="ECO:0000250"
FT   BINDING         228..234
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   515 AA;  56409 MW;  D8BB5DDF7D2DBBC0 CRC64;
     MTVAEQQPQH QGYANPGTPG SVVTFKKRYD NFIGGQWVPP VKGQYFDNAS PVDGKVFTQA
     ARSTAEDVEL ALDAAHRAAP AWGRTSVTER SNILLKIADR MEQNLEMLAV AETWDNGKPV
     RETLAADLPL AIDHFRYFAG CIRAQEGGLS QIDDSTVAYH FHEPLGVVGQ IIPWNFPLLM
     GVWKLAPALA AGNAVVLKPA EQTPASIMVL MELIADLLPE GVVNVVNGFG LEAGKPLASS
     PRIAKIAFTG ETNTGRLIMG YAADNLIPVT LELGGKSPNI FFDDVMMEDD AFLDKAVEGM
     VMFALNQGEV CTCPSRALIQ ESIYDRFMER AVQRVEAITM GHPLDPGTMI GAQASTEQLD
     KILSYLDIGR AEGAEVLTGG ERGQREGLEE GFYVKPTIFK GHNKMRIFQE EIFGPVLAAA
     TFKDEAEALE LANDTLYGLG AGLWTRDISR AYRMGRGIQA GRVWTNCYHV YPAHAAFGGY
     KQSGIGRENH RMMLDHYQQT KNLLVSYSPN KMGFF