ID   FRQ_LEPAU               Reviewed;         992 AA.
AC   Q01115;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Frequency clock protein;
GN   Name=FRQ;
OS   Leptosphaeria australiensis (Marine fungus) (Metasphaeria australiensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Leptosphaeria.
OX   NCBI_TaxID=40116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 66919 / 5165C;
RX   PubMed=9037100; DOI=10.1007/s004380050338;
RA   Lewis M.T., Morgan L.W., Feldman J.F.;
RT   "Analysis of frequency (frq) clock gene homologs: evidence for a helix-
RT   turn-helix transcription factor.";
RL   Mol. Gen. Genet. 253:401-414(1997).
CC   -!- FUNCTION: Circadian clock component involved in the generation of
CC       biological rhythms, in particular in rhythm stability, period length,
CC       and temperature compensation. Behaves as a negative element in
CC       circadian transcriptional loop (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FRQ family. {ECO:0000305}.
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DR   EMBL; U25851; AAB96844.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q01115; -.
DR   PRIDE; Q01115; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR018554; FRQ.
DR   Pfam; PF09421; FRQ; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..992
FT                   /note="Frequency clock protein"
FT                   /id="PRO_0000087342"
FT   REGION          1..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          515..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          783..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          872..992
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           550..554
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        40..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..543
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        784..804
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        887..905
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..936
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   992 AA;  107560 MW;  98E029B585F83AFF CRC64;
     MSDLKSKRRN APSLAQHTYP RRVSPENSVT LRHHRLARDA SLQANSSRSQ AATSSPRRNS
     SDESHDTGQS DANKWFDQSN LNPTANYDSN AMDVDPPFYQ RESESSNEGG KIPYHGGSVP
     MLKPTVTHSS SADDYRSVID DLTVEIQRLK EELKRYKQFG SDVMKNEKLF EIKVHGLPKR
     KKRELEATLR DFAASLAGTS STDMASSHKK KSSRHMNRMQ SSASGSMSKH ASSSAGSHSR
     PVDSAYASMS TGPNSSGTSL NRPSMSARAR TSEQKVENYL RDIPEGLYPR HMIMTEKERK
     KLIVRRLEQI FTGKMVRGAN TSNSYQVNSG LTPVTHDGQS GKAAGLHQPP SLKAPPINVE
     NIEPAREARI LPADNMKKSR SRDNESTSNS NQDQTESGGK TANSGSGSNT SPPIAPPPEQ
     RPTRPLDLDP HRTQVPSENM EYLRHLGLVP PELLPDSNDL EGDVAPDADG WIHLNLLCNL
     AQLHILNVTP DFIRSAVNEK STKFQLSRDG RKVRWRGGLD GTRFSSDSSG DNSQSPVGDE
     TDSSSKNGQR KKRKVVTADG QTTSAPSSKE ASKYDRQISQ SSDSFHYKPL FAHHPSSHET
     SLDTGSSYGP PEESAQGDSR WGLSGSGGTS QRKKRRVDGA IVYYSGAPFC TDLSGDPGDA
     GVDSQTGGIS PATYMQNAGQ AQAKAEARAE KGKVPPKAVR MVPIRSQSGS FLPHRPLTAF
     SPSTEDVPMS DVDEAIALED DIEMEFPWSD SQQYLEVRPL EPSGLGGVLP DDNFMVVVTT
     KRPHGMEPGE KTPALGRTKS DETTRTTDSI VNLLASMSTS GNENMPAGRP VLHKTGNIEI
     EYLSGRIKRL NPVPLPPPAI FFPPFSSTSS YNSELDLGSD ADDDESSEEF MSRRANPHQS
     DNEYPDDVDI TSGDEVGEEP DDELAPTDDD EEMESAGDEG GASRGRAAGP RSARPSLPSG
     KSAGHRAVRR TGSLAATAGG EESGYSSSAE ES