ID   FRQ_SORFI               Reviewed;         997 AA.
AC   Q09033;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Frequency clock protein;
GN   Name=FRQ;
OS   Sordaria fimicola.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX   NCBI_TaxID=27338;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FGSC 2918;
RX   PubMed=8194516; DOI=10.1002/j.1460-2075.1994.tb06507.x;
RA   Merrow M.W., Dunlap J.C.;
RT   "Intergeneric complementation of a circadian rhythmicity defect:
RT   phylogenetic conservation of structure and function of the clock gene
RT   frequency.";
RL   EMBO J. 13:2257-2266(1994).
CC   -!- FUNCTION: Circadian clock component involved in the generation of
CC       biological rhythms, in particular in rhythm stability, period length,
CC       and temperature compensation. Behaves as a negative element in
CC       circadian transcriptional loop.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FRQ family. {ECO:0000305}.
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DR   EMBL; L14467; AAA20825.1; -; Genomic_DNA.
DR   PIR; S44457; S44457.
DR   AlphaFoldDB; Q09033; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR018554; FRQ.
DR   Pfam; PF09421; FRQ; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..997
FT                   /note="Frequency clock protein"
FT                   /id="PRO_0000087343"
FT   REGION          1..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          524..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          665..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          889..908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          975..997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           569..573
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        23..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..577
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..687
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   997 AA;  109057 MW;  2581DDD2C62DFFF3 CRC64;
     MADSGDKSQG MRPPPFDSRG HPLPRRASPD KSITLHNHRL ARDASSRVIS SSALGVTGPQ
     PQPTSSPTRR DSSGESNDTG QSDPKSWFDQ SNRNPVAAFN DESNIMEVDP PFYQKETDSS
     NEDSRYPPGR NPSYPPRDTQ TQGFRATVAH SSSADDFRSV IDDLTVENKR LKEELKRYKQ
     FGSDMMRKEK LFEIKVHGLP RRKKRELEAT LREFAASLGD SSESTSQRRK AGRHGKAVHS
     SGVSLSKHDS SSSSRSRPVD SAYASMSTGR SSHAAHSSGP SLGRPSLSSK STSSQKVESY
     LRDTPDGLLP HHVVMTDKEK KKLVVRRLEQ LFTGKISGRN MQRIPSIPSM DAALVSEGTI
     MAPPRPPPEG SREACIQLQE GENPEKIRSS KGATSASNSG GDQTEVGGTV TAGGDGNGSG
     GRTVNNTSPP GVIAPDQRPT RPRDLDPDRV QIPSENMDYI RHLGLVSPEF LQGSRTSYQD
     VAPDAEGWVY LNLLCNLAQL HMINVTPSFI RQAVSEKSTK FQLSSDGRKI RWRGGTDGTK
     FSSDNGEDKS QKSPLTDDTE DGSDKTGRRK KQKTQQARSE IGRLGLSRSP SDTFHYKPMF
     VHCHASSAET SLEESASQGS EDFVDESNLA NSKWDFSGSG TTQQRRKRRY DGAIVYYTGA
     QFCTDLSGEP GDMSPTEQMT ATGEQEASGS GDEAGRVLQR TLSGSSLLVR PLSDDRARVA
     EALDFDPQNP PDLVSDDGFS PNDEDFVFPW CEDPAKTQVQ PLAKEVMGRS GLGGVLPDDH
     FAIFVTTRRV MRPTLQRHLS RSTTSEDTAE IIAERLASIR TSSPLPPPRS RNLILAPLQI
     EYVAGEFHRL NPASLPPPAM FYPPFSTDSS WDDGDDLVSV EEEVEEMEEE SFSEGQMSRR
     ANPHFSDNNT YMRKEDLAFD TETDVRMDSS HDHRMSSDSG LMMRSVMRRP VAVDGDGSPL
     ATVTGRDVDM LHTSSSVATA GGAESGYSSS MEDVSSS