FRQ_TRISN
ID FRQ_TRISN Reviewed; 1015 AA.
AC Q00586;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Frequency clock protein;
GN Name=FRQ;
OS Trichoderma spinulosum (Hypocrea spinulosa).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=1491020;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=FGSC 4896;
RX PubMed=9037100; DOI=10.1007/s004380050338;
RA Lewis M.T., Morgan L.W., Feldman J.F.;
RT "Analysis of frequency (frq) clock gene homologs: evidence for a helix-
RT turn-helix transcription factor.";
RL Mol. Gen. Genet. 253:401-414(1997).
CC -!- FUNCTION: Circadian clock component involved in the generation of
CC biological rhythms, in particular in rhythm stability, period length,
CC and temperature compensation. Behaves as a negative element in
CC circadian transcriptional loop (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FRQ family. {ECO:0000305}.
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DR EMBL; U25850; AAA68072.1; -; Genomic_DNA.
DR PIR; T42013; T42013.
DR AlphaFoldDB; Q00586; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR018554; FRQ.
DR Pfam; PF09421; FRQ; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Nucleus; Transcription; Transcription regulation.
FT CHAIN 1..1015
FT /note="Frequency clock protein"
FT /id="PRO_0000087341"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 584..588
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..924
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..948
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 110973 MW; EA49E732ED7414B1 CRC64;
MQPTEDLPRG TPLSSTGHPL PRRTSPEQSV TLRHHQLARD ASLKASLGSA PPNDSNENSS
SPRRASSGES HETGQSDAKK WFNQSNQNPT ATFDSNAMDV DPPFFQKESD SSNEDKPYQF
PPATIRIQSN ARSSSADDYR SVIDDLTVEI QKLKEELKRY KQRGPDMLRK DKLFEIKIHG
LPKRKKRELE ATLREFTATL EGSPNTSSSK RNSTTKPSRH ATRDRMYSGS GSKSQSKHAS
SSSGSHTRPV DSAYASMSTG AGSSGTSLNR PQGGSRFKTN EQKVDHYLRE IPEGLYPRFV
SMTEKEKKKL VVRRLEQIFT GKIGGKHVRR TQPTLTPAVS IALPAVQATS IDFSPQQQQQ
QQQQQQQQPK SNFITNPGAT FSSVPEPLRE ARILPQEHQY GHVAGQKGRS HDIGSASNSN
EDQTESGGNG NSSSNGNDSG TNPSPPMPPP PEQRPTRPRD LDPDRIQIPS ENMEYIRHLG
LVPPELLTNP PERTSFDFHP DEEGWVYLNL LCNMAQLHIM SVTPDFVRNA VVDLSAKFQL
SPDGRKIRWR GGTDGTKFSS ESSGDLSQRS PETDDTENTK GDNHKRQKTG HSTGDSGSSG
NNLPKFGGPQ VSASSESFHY KPLFLHQQSP NEQSSMEDGT LSSFGPIEES NADSRWGQSG
SGASNRRKRR RDGAIIYYSG APFCTDLSGD PGDTSPATYM LSSERERPDA QGQFARPLPF
RSGSGSSITR RPLSDAHLNL GSIPKLQLLN EGVSIPELVT DSGDESSKLS MEFPWSDEPQ
ILEVRPLEPC GLGGVRPEDH FMVVVTTRRS KLDARVGQRL EGQRKLSEEM TDIVVNRLAT
MSTSSPRPSV RRLSNMSDSS KIKIEYLSGR IKRLEPVSLP PPAIFFPPFS ADSCSEDDFG
SDGDDEFNSS EEFMSRRANP HQSDDYPDGV DLSSGDEDGE EPEDDIDASR MVDDMSLPGL
GRVPRGSQAS TEVVPGSSRG RSNSASAEAV LRAGGSSAAT AGGVESDFSI SSSQG
