FRS12_ARATH
ID FRS12_ARATH Reviewed; 788 AA.
AC Q3E7I5;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein FAR1-RELATED SEQUENCE 12;
GN Name=FRS12; OrderedLocusNames=At5g18960; ORFNames=F17K4.210;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=15591448; DOI=10.1104/pp.104.052191;
RA Lin R., Wang H.;
RT "Arabidopsis FHY3/FAR1 gene family and distinct roles of its members in
RT light control of Arabidopsis development.";
RL Plant Physiol. 136:4010-4022(2004).
CC -!- FUNCTION: Putative transcription activator involved in regulating light
CC control of development.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15591448}. Note=The
CC nuclear localization is independent of the light treatment.
CC -!- TISSUE SPECIFICITY: Expressed in hypocotyls, rosette and cauline
CC leaves, inflorescences stems, flowers and siliques.
CC {ECO:0000269|PubMed:15591448}.
CC -!- INDUCTION: Up-regulated in hypocotyls by far-red light treatment.
CC {ECO:0000269|PubMed:15591448}.
CC -!- SIMILARITY: Belongs to the FHY3/FAR1 family. {ECO:0000305}.
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DR EMBL; AC068655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92633.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69128.1; -; Genomic_DNA.
DR RefSeq; NP_001330829.1; NM_001343577.1.
DR RefSeq; NP_197397.1; NM_121901.2.
DR AlphaFoldDB; Q3E7I5; -.
DR BioGRID; 17290; 3.
DR IntAct; Q3E7I5; 3.
DR STRING; 3702.AT5G18960.1; -.
DR iPTMnet; Q3E7I5; -.
DR PaxDb; Q3E7I5; -.
DR PRIDE; Q3E7I5; -.
DR ProteomicsDB; 230531; -.
DR EnsemblPlants; AT5G18960.1; AT5G18960.1; AT5G18960.
DR EnsemblPlants; AT5G18960.2; AT5G18960.2; AT5G18960.
DR GeneID; 832014; -.
DR Gramene; AT5G18960.1; AT5G18960.1; AT5G18960.
DR Gramene; AT5G18960.2; AT5G18960.2; AT5G18960.
DR KEGG; ath:AT5G18960; -.
DR Araport; AT5G18960; -.
DR TAIR; locus:2144930; AT5G18960.
DR eggNOG; ENOG502QVUN; Eukaryota.
DR HOGENOM; CLU_008459_7_2_1; -.
DR InParanoid; Q3E7I5; -.
DR OMA; RFSCSQF; -.
DR OrthoDB; 145340at2759; -.
DR PhylomeDB; Q3E7I5; -.
DR PRO; PR:Q3E7I5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q3E7I5; baseline and differential.
DR Genevisible; Q3E7I5; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR004330; FAR1_DNA_bnd_dom.
DR InterPro; IPR031052; FHY3/FAR1.
DR InterPro; IPR018289; MULE_transposase_dom.
DR InterPro; IPR006564; Znf_PMZ.
DR InterPro; IPR007527; Znf_SWIM.
DR PANTHER; PTHR31669; PTHR31669; 2.
DR Pfam; PF03101; FAR1; 2.
DR Pfam; PF10551; MULE; 1.
DR Pfam; PF04434; SWIM; 1.
DR SMART; SM00575; ZnF_PMZ; 1.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..788
FT /note="Protein FAR1-RELATED SEQUENCE 12"
FT /id="PRO_0000363490"
FT DOMAIN 57..133
FT /note="FAR1 1"
FT DOMAIN 225..301
FT /note="FAR1 2"
FT DOMAIN 399..495
FT /note="MULE"
FT ZN_FING 674..710
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT REGION 127..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 90497 MW; D00C7EA78D2470AD CRC64;
MESVDTELTS FNNMVAKSSY PVRILHHNNG ISEDEEGGSG VEPYVGLEFD TAEEAREFYN
AYAARTGFKV RTGQLYRSRT DGTVSSRRFV CSKEGFQLNS RTGCTAFIRV QRRDTGKWVL
DQIQKEHNHE LGGEGSVEET TPRPSRAPAP TKLGVTVNPH RPKMKVVDES DRETRSCPGG
FKRFKGGGGE GEVSDDHHQT QQAKAVTGTE PYAGLEFGSA NEACQFYQAY AEVVGFRVRI
GQLFRSKVDG SITSRRFVCS REGFQHPSRM GCGAYMRIKR QDSGGWIVDR LNKDHNHDLE
PGKKNDAGMK KIPDDGTGGL DSVDLIELND FGNNHIKKTR ENRIGKEWYP LLLDYFQSRQ
TEDMGFFYAV ELDVNNGSCM SIFWADSRAR FACSQFGDSV VFDTSYRKGS YSVPFATIIG
FNHHRQPVLL GCAMVADESK EAFLWLFQTW LRAMSGRRPR SIVADQDLPI QQALVQVFPG
AHHRYSAWQI REKERENLIP FPSEFKYEYE KCIYQTQTIV EFDSVWSALI NKYGLRDDVW
LREIYEQREN WVPAYLRASF FAGIPINGTI EPFFGASLDA LTPLREFISR YEQALEQRRE
EERKEDFNSY NLQPFLQTKE PVEEQCRRLY TLTVFRIFQN ELVQSYNYLC LKTYEEGAIS
RFLVRKCGNE SEKHAVTFSA SNLNSSCSCQ MFEHEGLLCR HILKVFNLLD IRELPSRYIL
HRWTKNAEFG FVRDMESGVS AQDLKALMVW SLREAASKYI EFGTSSLEKY KLAYEIMREG
GKKLCWQR
