FRS4_ARATH
ID FRS4_ARATH Reviewed; 732 AA.
AC Q6NQJ7; F4I2C4; Q2V4C5; Q9SFW7; Q9SGQ3;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein FAR1-RELATED SEQUENCE 4;
GN Name=FRS4; OrderedLocusNames=At1g76320; ORFNames=F15M4.18, T23E18.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=15591448; DOI=10.1104/pp.104.052191;
RA Lin R., Wang H.;
RT "Arabidopsis FHY3/FAR1 gene family and distinct roles of its members in
RT light control of Arabidopsis development.";
RL Plant Physiol. 136:4010-4022(2004).
CC -!- FUNCTION: Putative transcription activator involved in regulating light
CC control of development.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15591448}. Note=The
CC nuclear localization is independent of the light treatment.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NQJ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NQJ7-2; Sequence=VSP_036310;
CC -!- TISSUE SPECIFICITY: Expressed in hypocotyls, rosette and cauline
CC leaves, inflorescences stems, flowers and siliques.
CC {ECO:0000269|PubMed:15591448}.
CC -!- INDUCTION: Up-regulated in hypocotyls by far-red light treatment.
CC {ECO:0000269|PubMed:15591448}.
CC -!- SIMILARITY: Belongs to the FHY3/FAR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF16668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009978; AAF17632.1; -; Genomic_DNA.
DR EMBL; AC012394; AAF16668.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35824.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35825.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58378.1; -; Genomic_DNA.
DR EMBL; BT010456; AAQ62876.1; -; mRNA.
DR EMBL; AK221406; BAD94369.1; -; mRNA.
DR PIR; G96790; G96790.
DR RefSeq; NP_001031286.1; NM_001036209.2. [Q6NQJ7-2]
DR RefSeq; NP_001320820.1; NM_001334722.1.
DR RefSeq; NP_001320821.1; NM_001334723.1. [Q6NQJ7-1]
DR RefSeq; NP_177759.1; NM_106282.5. [Q6NQJ7-1]
DR AlphaFoldDB; Q6NQJ7; -.
DR BioGRID; 29184; 4.
DR IntAct; Q6NQJ7; 4.
DR STRING; 3702.AT1G76320.1; -.
DR PaxDb; Q6NQJ7; -.
DR PRIDE; Q6NQJ7; -.
DR ProteomicsDB; 247378; -. [Q6NQJ7-1]
DR EnsemblPlants; AT1G76320.1; AT1G76320.1; AT1G76320. [Q6NQJ7-1]
DR EnsemblPlants; AT1G76320.2; AT1G76320.2; AT1G76320. [Q6NQJ7-2]
DR EnsemblPlants; AT1G76320.4; AT1G76320.4; AT1G76320. [Q6NQJ7-1]
DR GeneID; 843965; -.
DR Gramene; AT1G76320.1; AT1G76320.1; AT1G76320. [Q6NQJ7-1]
DR Gramene; AT1G76320.2; AT1G76320.2; AT1G76320. [Q6NQJ7-2]
DR Gramene; AT1G76320.4; AT1G76320.4; AT1G76320. [Q6NQJ7-1]
DR KEGG; ath:AT1G76320; -.
DR Araport; AT1G76320; -.
DR TAIR; locus:2014639; AT1G76320.
DR eggNOG; ENOG502QQDK; Eukaryota.
DR InParanoid; Q6NQJ7; -.
DR PRO; PR:Q6NQJ7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6NQJ7; baseline and differential.
DR Genevisible; Q6NQJ7; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR004330; FAR1_DNA_bnd_dom.
DR InterPro; IPR031052; FHY3/FAR1.
DR InterPro; IPR018289; MULE_transposase_dom.
DR InterPro; IPR006564; Znf_PMZ.
DR InterPro; IPR007527; Znf_SWIM.
DR PANTHER; PTHR31669; PTHR31669; 1.
DR Pfam; PF03101; FAR1; 1.
DR Pfam; PF10551; MULE; 1.
DR Pfam; PF04434; SWIM; 1.
DR SMART; SM00575; ZnF_PMZ; 1.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..732
FT /note="Protein FAR1-RELATED SEQUENCE 4"
FT /id="PRO_0000363482"
FT DOMAIN 11..97
FT /note="FAR1"
FT DOMAIN 212..308
FT /note="MULE"
FT ZN_FING 490..526
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT REGION 623..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 666..667
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036310"
FT CONFLICT 586
FT /note="I -> V (in Ref. 3; AAQ62876 and 4; BAD94369)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 732 AA; 85151 MW; E40EEE99ECF6E56B CRC64;
MEFETHEDAY LFYKDYAKSV GFGTAKLSSR RSRASKEFID AKFSCIRYGS KQQSDDAINP
RASPKIGCKA SMHVKRRPDG KWYVYSFVKE HNHDLLPEQA HYFRSHRNTE LVKSNDSRLR
RKKNTPLTDC KHLSAYHDLD FIDGYMRNQH DKGRRLVLDT GDAEILLEFL MRMQEENPKF
FFAVDFSEDH LLRNVFWVDA KGIEDYKSFS DVVSFETSYF VSKYKVPLVL FVGVNHHVQP
VLLGCGLLAD DTVYTYVWLM QSWLVAMGGQ KPKVMLTDQN NAIKAAIAAV LPETRHCYCL
WHVLDQLPRN LDYWSMWQDT FMKKLFKCIY RSWSEEEFDR RWLKLIDKFH LRDVPWMRSL
YEERKFWAPT FMRGITFAGL SMRCRSESVN SLFDRYVHPE TSLKEFLEGY GLMLEDRYEE
EAKADFDAWH EAPELKSPSP FEKQMLLVYS HEIFRRFQLE VLGAAACHLT KESEEGTTYS
VKDFDDEQKY LVDWDEFKSD IYCSCRSFEY KGYLCRHAIV VLQMSGVFTI PINYVLQRWT
NAARNRHQIS RNLELVQSNI RRFNDLCRRA IILGEEGSLS QESYDIAMFA MKEAFKQCAV
TINTIKHPAR CEEAAIQAGD PVQEENQYGS TSTQIGPEPN IHAGNVPWQA ETRREKRSSL
NNTSKKAKHV AQSETVGEGS QEGFQHVADP RQSQAVLAGQ FHNTMPGVFQ NLINTNFQNI
PATNMHQNNP PG
