ID   FRSA_KLEP3              Reviewed;         414 AA.
AC   B5Y1D9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Esterase FrsA {ECO:0000255|HAMAP-Rule:MF_01063};
DE            EC=3.1.1.1 {ECO:0000255|HAMAP-Rule:MF_01063};
GN   Name=frsA {ECO:0000255|HAMAP-Rule:MF_01063}; OrderedLocusNames=KPK_4481;
OS   Klebsiella pneumoniae (strain 342).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=507522;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=342;
RX   PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA   Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA   Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA   Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA   Methe B.A.;
RT   "Complete genome sequence of the N2-fixing broad host range endophyte
RT   Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL   PLoS Genet. 4:E1000141-E1000141(2008).
CC   -!- FUNCTION: Catalyzes the hydrolysis of esters. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC         Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01063};
CC   -!- SIMILARITY: Belongs to the FrsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
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DR   EMBL; CP000964; ACI11485.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5Y1D9; -.
DR   SMR; B5Y1D9; -.
DR   ESTHER; klep7-y243; Duf_1100-R.
DR   EnsemblBacteria; ACI11485; ACI11485; KPK_4481.
DR   KEGG; kpe:KPK_4481; -.
DR   HOGENOM; CLU_036819_0_0_6; -.
DR   OMA; NIPWVDH; -.
DR   OrthoDB; 721431at2; -.
DR   BioCyc; KPNE507522:GI0B-4462-MON; -.
DR   Proteomes; UP000001734; Chromosome.
DR   GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   HAMAP; MF_01063; FrsA; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR043423; FrsA.
DR   InterPro; IPR010520; FrsA-like.
DR   Pfam; PF06500; FrsA-like; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Serine esterase.
FT   CHAIN           1..414
FT                   /note="Esterase FrsA"
FT                   /id="PRO_1000136519"
SQ   SEQUENCE   414 AA;  46903 MW;  EA74A51E9005BC31 CRC64;
     MSQANLSETL FKPRFKHPET STLVRRFSAG KPQAMQSALS GNHVDHWYRL INRLMWIWRG
     VTPQEILDVQ ARIVMSEAER TDPELFDTVI GYRGGNWIFE WAKEAMQWQQ KAGQEADPLL
     SGRHWLHASN LYSIAAYPHI KGDELAEQAQ ALANRAYEEA AQRLPGSLRE LEFTIPGGSP
     ITGFLHMPKG DGPFPTVLMC GGLDSLQTDY YNLYENYFSP LGIAMLTIDM PSIGFSSKWT
     LNQDTSLLHQ HALRHLENVP WVDHTRVAAF GFRFGANIAV RLGYLEPQRL KAVACLGPVV
     HGLLVDPLHQ GRVPEMYLDV LASRLGMHDA SDEALRVELN RYSLKTQGLL GRRCPTPMLS
     GFWKDDPFSP EEESRLITSS SADGKLLEIP FNPVYRNFDH ALRQIARWIN HRFG