ID   FRSA_KLEP7              Reviewed;         414 AA.
AC   A6T533;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Esterase FrsA {ECO:0000255|HAMAP-Rule:MF_01063};
DE            EC=3.1.1.1 {ECO:0000255|HAMAP-Rule:MF_01063};
GN   Name=frsA {ECO:0000255|HAMAP-Rule:MF_01063};
GN   OrderedLocusNames=KPN78578_02430; ORFNames=KPN_00251;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of esters. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC         Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01063};
CC   -!- SIMILARITY: Belongs to the FrsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
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DR   EMBL; CP000647; ABR75704.1; -; Genomic_DNA.
DR   RefSeq; WP_002889742.1; NC_009648.1.
DR   AlphaFoldDB; A6T533; -.
DR   SMR; A6T533; -.
DR   STRING; 272620.KPN_00251; -.
DR   ESTHER; klep7-y243; Duf_1100-R.
DR   jPOST; A6T533; -.
DR   EnsemblBacteria; ABR75704; ABR75704; KPN_00251.
DR   KEGG; kpn:KPN_00251; -.
DR   HOGENOM; CLU_036819_0_0_6; -.
DR   OMA; NIPWVDH; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   HAMAP; MF_01063; FrsA; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR043423; FrsA.
DR   InterPro; IPR010520; FrsA-like.
DR   Pfam; PF06500; FrsA-like; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..414
FT                   /note="Esterase FrsA"
FT                   /id="PRO_1000064484"
SQ   SEQUENCE   414 AA;  46932 MW;  824C2BC164E41CDB CRC64;
     MSQANLSETL FKPRFKHPET STLVRRFSAG KPQAMQSALS GNHVDHWYRL INRLMWIWRG
     VTPQEILDVQ ARIVMSEAER TDPELFDTVI GYRGGNWIFE WAKEAMQWQQ KAGQEADPLL
     SGRHWLHASN LYSIAAYPHI KGDELAEQAQ ALANRAYEEA AQRLPGSLRE LEFTIPGGSP
     ITGFLHMPKG EGPFPTVLMC GGLDSLQTDY YNLYENYFSP LGIAMLTIDM PSIGFSSKWT
     LNQDTSLLHQ HALRHLENVP WIDHTRVAAF GFRFGANIAV RLGYLEPQRL KAVACLGPVV
     HGLLVDPLHQ GRVPEMYLDV LASRLGMHDA SDEALRVELN RYSLKTQGLL GRRCPTPMLS
     GFWKDDPFSP EEESRLITSS SADGKLLEIP FNPVYRNFDH ALRQIARWIN HRFG