ID   FRSA_SALTY              Reviewed;         414 AA.
AC   P37722;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   13-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Esterase FrsA {ECO:0000255|HAMAP-Rule:MF_01063};
DE            EC=3.1.1.1 {ECO:0000255|HAMAP-Rule:MF_01063};
GN   Name=frsA {ECO:0000255|HAMAP-Rule:MF_01063}; OrderedLocusNames=STM0318;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36.
RC   STRAIN=LT2;
RA   Bryant D.W., Rossetto F.E., O'Reilly C., Nieboer E., Turnbull J.;
RL   Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=7920643; DOI=10.1038/ng0694-205;
RA   Robison K., Gilbert W., Church G.M.;
RT   "Large scale bacterial gene discovery by similarity search.";
RL   Nat. Genet. 7:205-214(1994).
CC   -!- FUNCTION: Catalyzes the hydrolysis of esters. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC         Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01063};
CC   -!- SIMILARITY: Belongs to the FrsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
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DR   EMBL; AE006468; AAL19274.1; -; Genomic_DNA.
DR   EMBL; X63336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_459315.1; NC_003197.2.
DR   RefSeq; WP_000189588.1; NC_003197.2.
DR   AlphaFoldDB; P37722; -.
DR   SMR; P37722; -.
DR   STRING; 99287.STM0318; -.
DR   ESTHER; salty-yafa; Duf_1100-R.
DR   PaxDb; P37722; -.
DR   EnsemblBacteria; AAL19274; AAL19274; STM0318.
DR   GeneID; 1251837; -.
DR   KEGG; stm:STM0318; -.
DR   PATRIC; fig|99287.12.peg.338; -.
DR   HOGENOM; CLU_036819_0_0_6; -.
DR   OMA; NIPWVDH; -.
DR   PhylomeDB; P37722; -.
DR   BioCyc; SENT99287:STM0318-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   HAMAP; MF_01063; FrsA; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR043423; FrsA.
DR   InterPro; IPR010520; FrsA-like.
DR   Pfam; PF06500; FrsA-like; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..414
FT                   /note="Esterase FrsA"
FT                   /id="PRO_0000197157"
FT   CONFLICT        28..30
FT                   /note="NRG -> IV (in Ref. 2; X63336)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        35..36
FT                   /note="MQ -> CI (in Ref. 2; X63336)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   414 AA;  47160 MW;  B0B2843A26B263D1 CRC64;
     MTQANLSETL FKPRFKHTET STLVRRFNRG SQPPMQSALD GKNVPHWYRM INRLMWIWRG
     VDPREILDVQ ARIVMSDAER TDDDLYDTVI GYRGGNWIYE WAKQAMDWQQ KACQEQDAMR
     SGRYWLHAST LYNIAAYPHL KGDELAEQAQ ALANRAYEEA AQRLPGSLRE MEFAVPGGSP
     VTAFLHMPKG DGPFPTVLMC GGLDAMQTDY YTLYERYFAP RGIAMLTLDM PSVGFSSKWK
     LTQDSSLLHQ HVLKALPNVP WVDHTRVAAF GFRFGANVAV RLAYLEAPRL KAVACLGPVV
     HALLSDPQRQ STVPEMYLDV LASRLGMHDA SDEALRVELN RYSLKVQGLL GRRCPTPMLS
     GFWKNDPFSP EEESRLITTS SSDGKLIEIP FNPVYRNFDR ALQEITDWIN HRLC