ID   FRSA_VIBCH              Reviewed;         415 AA.
AC   Q9KPT6;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Esterase FrsA {ECO:0000255|HAMAP-Rule:MF_01063};
DE            EC=3.1.1.1 {ECO:0000255|HAMAP-Rule:MF_01063};
GN   Name=frsA {ECO:0000255|HAMAP-Rule:MF_01063}; OrderedLocusNames=VC_2276;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Catalyzes the hydrolysis of esters. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC         Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01063};
CC   -!- SIMILARITY: Belongs to the FrsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
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DR   EMBL; AE003852; AAF95420.1; -; Genomic_DNA.
DR   PIR; H82095; H82095.
DR   RefSeq; NP_231907.1; NC_002505.1.
DR   RefSeq; WP_001287570.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KPT6; -.
DR   SMR; Q9KPT6; -.
DR   STRING; 243277.VC_2276; -.
DR   ESTHER; vibch-y2276; Duf_1100-R.
DR   DNASU; 2613198; -.
DR   EnsemblBacteria; AAF95420; AAF95420; VC_2276.
DR   GeneID; 57740898; -.
DR   KEGG; vch:VC_2276; -.
DR   PATRIC; fig|243277.26.peg.2171; -.
DR   eggNOG; COG1073; Bacteria.
DR   HOGENOM; CLU_036819_0_0_6; -.
DR   OMA; NIPWVDH; -.
DR   BioCyc; VCHO:VC2276-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   HAMAP; MF_01063; FrsA; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR043423; FrsA.
DR   InterPro; IPR010520; FrsA-like.
DR   Pfam; PF06500; FrsA-like; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..415
FT                   /note="Esterase FrsA"
FT                   /id="PRO_0000197159"
SQ   SEQUENCE   415 AA;  46737 MW;  4F9F3795D4BA2AE3 CRC64;
     MSEASSKNLS ETLFQNHKQA KETSSLTQYM PSSLELLDTR REQSSQAWYR NLRRLQWIWQ
     GVDPVEQEEI LARIASSKHS RTHDEWLDTV MGYRSGNWTY EWTRVGMLHQ KQAAERQGEE
     AADQMFAAAL YYSIAGYPHL RNDNLALQAQ VLANNAYQEA AKLTGFVVKR LEFSYQNKKI
     AGYLHLRNTD SPKPVVLVSA GLDSLQTDMW RLFRDYLAKR DIAMLTIDMP SLGASSHWPL
     TEDSSCLHQA VLNQLADLPW VDHFRIGLIG FRFGGNAMAR LAFLESDKVK ACVSLGAPIH
     DIFTSPNKLA AMPKMYLDVL ASRLGKNVVD VRSLSGQLMA WSLKVQGFMS GRRTKTPILA
     LGLEGDPVSP YSDNQLVALF SQGGQAKKVK SKTISQGYEQ SLDLAINWLE DELCK