ID   FRSA_VIBPA              Reviewed;         415 AA.
AC   Q87RV2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Esterase FrsA {ECO:0000255|HAMAP-Rule:MF_01063};
DE            EC=3.1.1.1 {ECO:0000255|HAMAP-Rule:MF_01063};
GN   Name=frsA {ECO:0000255|HAMAP-Rule:MF_01063}; OrderedLocusNames=VP0674;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: Catalyzes the hydrolysis of esters. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC         Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01063};
CC   -!- SIMILARITY: Belongs to the FrsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
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DR   EMBL; BA000031; BAC58937.1; -; Genomic_DNA.
DR   RefSeq; NP_797053.1; NC_004603.1.
DR   RefSeq; WP_005455935.1; NC_004603.1.
DR   AlphaFoldDB; Q87RV2; -.
DR   SMR; Q87RV2; -.
DR   STRING; 223926.28805660; -.
DR   ESTHER; vibpa-y674; Duf_1100-R.
DR   EnsemblBacteria; BAC58937; BAC58937; BAC58937.
DR   GeneID; 1188149; -.
DR   KEGG; vpa:VP0674; -.
DR   PATRIC; fig|223926.6.peg.642; -.
DR   eggNOG; COG1073; Bacteria.
DR   HOGENOM; CLU_036819_0_0_6; -.
DR   OMA; NIPWVDH; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   HAMAP; MF_01063; FrsA; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR043423; FrsA.
DR   InterPro; IPR010520; FrsA-like.
DR   Pfam; PF06500; FrsA-like; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Serine esterase.
FT   CHAIN           1..415
FT                   /note="Esterase FrsA"
FT                   /id="PRO_0000197160"
SQ   SEQUENCE   415 AA;  47107 MW;  4D4C39FE60DAC63D CRC64;
     MSEDVSKNLS ETLFVKHKQA KETSALTQYM PTSKKILDDR EQQEDRAWYR HLRRLQWAWQ
     GLSPIEMEGV LSRIASSTHS RTHDDWLDTV MGYHSGNWTF EWIKLGMEHQ RRANDLKGED
     AADELFTASL CFSIAGYPHL KNDNLALQAQ VLANKAYSEG AEKTQYTIKQ IEVPYQKRKI
     IANLHLPRTD KQLPVVMVSA GLDSLQTDMW RLFRNHFAPK DIAMLTVDMP SVGHSSHWPL
     TEDSSCLHQA VLNELYSIPY VDHHKVGLVG FRFGGNAMVR LSFLEQEKIK ACVALGAPVH
     DLFTSPKKLQ KMPKMYLDML ASRLGKSAVD INSMAGQMMA WSLKVQGFLS SRKTKVPILA
     LSLEGDPVSP YSDNQLVALF SHYGQAKKIS SKTITKGYEQ SLDLAIKWLE DELLR