ID   FRSA_YERPG              Reviewed;         415 AA.
AC   A9R2X3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Esterase FrsA {ECO:0000255|HAMAP-Rule:MF_01063};
DE            EC=3.1.1.1 {ECO:0000255|HAMAP-Rule:MF_01063};
GN   Name=frsA {ECO:0000255|HAMAP-Rule:MF_01063};
GN   OrderedLocusNames=YpAngola_A3303;
OS   Yersinia pestis bv. Antiqua (strain Angola).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Angola;
RX   PubMed=20061468; DOI=10.1128/jb.01518-09;
RA   Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA   Achtman M., Lindler L.E., Ravel J.;
RT   "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT   new insights into the evolution and pangenome of the plague bacterium.";
RL   J. Bacteriol. 192:1685-1699(2010).
CC   -!- FUNCTION: Catalyzes the hydrolysis of esters. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC         Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01063};
CC   -!- SIMILARITY: Belongs to the FrsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01063}.
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DR   EMBL; CP000901; ABX87550.1; -; Genomic_DNA.
DR   RefSeq; WP_002208703.1; NZ_CP009935.1.
DR   AlphaFoldDB; A9R2X3; -.
DR   SMR; A9R2X3; -.
DR   ESTHER; yerpe-y3224; Duf_1100-R.
DR   GeneID; 66842669; -.
DR   KEGG; ypg:YpAngola_A3303; -.
DR   OMA; NIPWVDH; -.
DR   GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   HAMAP; MF_01063; FrsA; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR043423; FrsA.
DR   InterPro; IPR010520; FrsA-like.
DR   Pfam; PF06500; FrsA-like; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Serine esterase.
FT   CHAIN           1..415
FT                   /note="Esterase FrsA"
FT                   /id="PRO_1000136530"
SQ   SEQUENCE   415 AA;  47007 MW;  8AF24896EBD7D2C8 CRC64;
     MAQANLSEIL FKPKFKHPET STLVRRTHCN HVVNIHSALD GDTANHWYRM INRLMWTWRG
     IDPLEIEEVL SRIACSKAEH SNNELLDTVV GYRNGNWIYE WANQGMMWQQ KAMEETDPGS
     AGQFWLNAAN LYSIASYPHL KGDELSEQAE VLSNRAYEEA AKYLPYTLKE LTFPISDGGS
     LSGFLHMPTV GSAPFPTVLM CGGLDTLQSD YHRLFRDYLE PKGIAMLTID LPSVGASSRW
     KLTQDTSYLH QQVLQALADV PWVDHQRVSV FGFRFGANVA VRLGYLEPQR VRAVACLGPI
     VHHLLCNSDS LRKVPDMYMD VMASRLGMAD STDETLNTEM NRYSLKTQGL LGRRCQTPML
     AGFWENDPFS PKEEAKLICS SSADGKLLAI PSKPLYENFH RALLQTSEWL EDKMR