ID   FRUF_BIFLO              Reviewed;         356 AA.
AC   Q8G846;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Fructose import permease protein FruF {ECO:0000305};
GN   Name=fruF {ECO:0000303|PubMed:22102285};
GN   OrderedLocusNames=BL0035 {ECO:0000312|EMBL:AAN23902.1};
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INTERACTION WITH FRUK AND FRUE.
RC   STRAIN=NCC 2705;
RX   PubMed=22102285; DOI=10.1074/jbc.m111.266213;
RA   Wei X., Guo Y., Shao C., Sun Z., Zhurina D., Liu D., Liu W., Zou D.,
RA   Jiang Z., Wang X., Zhao J., Shang W., Li X., Liao X., Huang L.,
RA   Riedel C.U., Yuan J.;
RT   "Fructose uptake in Bifidobacterium longum NCC2705 is mediated by an ATP-
RT   binding cassette transporter.";
RL   J. Biol. Chem. 287:357-367(2012).
CC   -!- FUNCTION: Part of the high-affinity ABC transporter complex FruEKFG
CC       involved in fructose uptake. Can also transport ribose and xylose, with
CC       lower affinity. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000269|PubMed:22102285}.
CC   -!- SUBUNIT: The complex is composed of an ATP-binding protein (FruK), two
CC       transmembrane proteins (FruF and FruG) and a solute-binding protein
CC       (FruE). {ECO:0000269|PubMed:22102285}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; AE014295; AAN23902.1; -; Genomic_DNA.
DR   RefSeq; NP_695266.1; NC_004307.2.
DR   RefSeq; WP_007053224.1; NC_004307.2.
DR   AlphaFoldDB; Q8G846; -.
DR   STRING; 206672.BL0035; -.
DR   TCDB; 3.A.1.2.23; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAN23902; AAN23902; BL0035.
DR   GeneID; 66505651; -.
DR   KEGG; blo:BL0035; -.
DR   PATRIC; fig|206672.9.peg.37; -.
DR   HOGENOM; CLU_028880_3_0_11; -.
DR   OMA; VWNGFLV; -.
DR   PhylomeDB; Q8G846; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..356
FT                   /note="Fructose import permease protein FruF"
FT                   /id="PRO_0000439270"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   356 AA;  37049 MW;  366EA7895C63FB8F CRC64;
     MAEKAKAEGN NFVKKLLSSN LTWSIVAFIL LVIICTIFQH DFLALSWNSN TGGLAGPLIT
     MLQESARYLM IATGMTLVIS TAGIDLSVGS VMAVAGAAAM QTLSNGMNVW LSILIALAVG
     LAIGCVNGAL VSFLGLQPFI TTLIMMLAGR GMAKVITSGE NTDASAVAGN EPLKWFANGF
     ILGIPANFVI AVIIVILVGL LCRKTAMGMM IEAVGINQEA SRMTGIKPKK ILFLVYAISG
     FLAAIAGLFA TASVMRVDVV KTGQDLEMYA ILAVVIGGTS LLGGKFSLAG SAVGAVIIAM
     IRKTIITLGV NAEATPAFFA VVVIVICVMQ APKIHNLSAN MKRKRALKAQ AKAVAA