ID   FRUG_BIFLO              Reviewed;         340 AA.
AC   Q8G845;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Fructose import permease protein FruG {ECO:0000305};
GN   Name=fruG {ECO:0000303|PubMed:22102285};
GN   OrderedLocusNames=BL0036 {ECO:0000312|EMBL:AAN23903.1};
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INTERACTION WITH FRUK AND FRUE.
RC   STRAIN=NCC 2705;
RX   PubMed=22102285; DOI=10.1074/jbc.m111.266213;
RA   Wei X., Guo Y., Shao C., Sun Z., Zhurina D., Liu D., Liu W., Zou D.,
RA   Jiang Z., Wang X., Zhao J., Shang W., Li X., Liao X., Huang L.,
RA   Riedel C.U., Yuan J.;
RT   "Fructose uptake in Bifidobacterium longum NCC2705 is mediated by an ATP-
RT   binding cassette transporter.";
RL   J. Biol. Chem. 287:357-367(2012).
CC   -!- FUNCTION: Part of the high-affinity ABC transporter complex FruEKFG
CC       involved in fructose uptake. Can also transport ribose and xylose, with
CC       lower affinity. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000269|PubMed:22102285}.
CC   -!- SUBUNIT: The complex is composed of an ATP-binding protein (FruK), two
CC       transmembrane proteins (FruF and FruG) and a solute-binding protein
CC       (FruE). {ECO:0000269|PubMed:22102285}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; AE014295; AAN23903.1; -; Genomic_DNA.
DR   RefSeq; NP_695267.1; NC_004307.2.
DR   RefSeq; WP_007053225.1; NC_004307.2.
DR   AlphaFoldDB; Q8G845; -.
DR   STRING; 206672.BL0036; -.
DR   TCDB; 3.A.1.2.23; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAN23903; AAN23903; BL0036.
DR   GeneID; 66505650; -.
DR   KEGG; blo:BL0036; -.
DR   PATRIC; fig|206672.9.peg.38; -.
DR   HOGENOM; CLU_028880_3_3_11; -.
DR   OMA; IGFWGIS; -.
DR   PhylomeDB; Q8G845; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..340
FT                   /note="Fructose import permease protein FruG"
FT                   /id="PRO_0000439271"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   340 AA;  35850 MW;  A46F22D58F4A82A8 CRC64;
     MTTATANKVK APKKGFKLDR QMIPTLAAVV IFILMIIMGQ ALFGTYIRLG FISSLFIDHA
     YLIILAVAMT LPILTGGIDL SVGAIVAITA VVGLKLANAG VPAFLVMIIM LLIGAVFGLL
     AGTLIEEFNM QPFIATLSTM FLARGLASII STDSLTFPQG NDFSFISNVI KIIDNPKISN
     DLSFNVGVII ALVVVVFGYV FLHHTRTGRT IYAIGGSRSS AELMGLPVKR TQYIIYLTSA
     TLAALASIVY TANIGSAKNT VGVGWELDAV ASVVIGGTII TGGFGYVLGS VLGSLVRSIL
     DPLTSDFGVP AEWTTIVIGL MILVFVVLQR AVMAVGGDKK