FRU_DROME
ID FRU_DROME Reviewed; 955 AA.
AC Q8IN81; A4V334; O44708; P91618; P91619; Q24004; Q29QE0; Q7KSD2; Q7KSD5;
AC Q7KSD6; Q8IN80; Q8IN82; Q8IN83; Q8IS35; Q8IS36; Q9GU18; Q9GU19; Q9GU20;
AC Q9GU21; Q9GU22; Q9VE64; Q9VE65; Q9VE66; Q9VE67;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Sex determination protein fruitless;
GN Name=fru; Synonyms=BTB-VI; ORFNames=CG14307;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAN13776.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MALE-I AND FEMALE-I), FUNCTION, TISSUE
RP SPECIFICITY, INTERACTION WITH TRA, AND DISRUPTION PHENOTYPE.
RC STRAIN=Oregon-R;
RX PubMed=8978612; DOI=10.1016/s0092-8674(00)81802-4;
RA Ryner L.C., Goodwin S.F., Castrillon D.H., Anand A., Villella A.,
RA Baker B.S., Hall J.C., Taylor B.J., Wasserman S.A.;
RT "Control of male sexual behavior and sexual orientation in Drosophila by
RT the fruitless gene.";
RL Cell 87:1079-1089(1996).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FEMALE-A), FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Canton-S; TISSUE=Head;
RX PubMed=8790392; DOI=10.1073/pnas.93.18.9687;
RA Ito H., Fujitani K., Usui K., Shimizu-Nishikawa K., Tanaka S., Yamamoto D.;
RT "Sexual orientation in Drosophila is altered by the satori mutation in the
RT sex-determination gene fruitless that encodes a zinc finger protein with a
RT BTB domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:9687-9692(1996).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MALE-A; FEMALE-A; MALE-B; FEMALE-B;
RP TYPE-C; TYPE-D; MALE-E AND FEMALE-E), FUNCTION, TISSUE SPECIFICITY, AND
RP INTERACTION WITH TRA.
RC STRAIN=Canton-S; TISSUE=Head;
RX PubMed=10934470; DOI=10.1038/35019537;
RA Usui-Aoki K., Ito H., Ui-Tei K., Takahashi K., Lukacsovich T., Awano W.,
RA Nakata H., Piao Z.F., Nilsson E.E., Tomida J.-Y., Yamamoto D.;
RT "Formation of the male-specific muscle in female Drosophila by ectopic
RT fruitless expression.";
RL Nat. Cell Biol. 2:500-506(2000).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5] {ECO:0000305}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MALE-A).
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-210 (ISOFORMS J AND
RP FEMALE-I/FEMALE-A/TYPE-D/TYPE-C/FEMALE-B/FEMALE-E).
RA Davis T., Ito H.;
RT "Genomic structure of the fruitless gene in Drosophila melanogaster.";
RL Dros. Info. Service 84:65-66(2001).
RN [8] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 104-218.
RX PubMed=7938017; DOI=10.1073/pnas.91.22.10717;
RA Zollman S., Godt D., Prive G.G., Couderc J.-L., Laski F.A.;
RT "The BTB domain, found primarily in zinc finger proteins, defines an
RT evolutionarily conserved family that includes several developmentally
RT regulated genes in Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:10717-10721(1994).
RN [9]
RP FUNCTION.
RX PubMed=9418892; DOI=10.1128/mcb.18.1.450;
RA Heinrichs V., Ryner L.C., Baker B.S.;
RT "Regulation of sex-specific selection of fruitless 5' splice sites by
RT transformer and transformer-2.";
RL Mol. Cell. Biol. 18:450-458(1998).
RN [10]
RP FUNCTION.
RC STRAIN=Canton-S;
RX PubMed=12435630; DOI=10.1101/gad.1010302;
RA Dauwalder B., Tsujimoto S., Moss J., Mattox W.;
RT "The Drosophila takeout gene is regulated by the somatic sex-determination
RT pathway and affects male courtship behavior.";
RL Genes Dev. 16:2879-2892(2002).
CC -!- FUNCTION: Probably acts as a transcriptional regulator. Part of the
CC somatic sex determination hierarchy; sex determination genes
CC transformer (tra) and transformer-2 (tra-2) switch fru splicing from
CC the male-specific pattern to the female-specific pattern through
CC activation of the female-specific fru 5'-splice site. Vital for the
CC development of males and females. Controls the development of the male
CC specific abdominal muscle of Lawrence. Plays a role in male courtship
CC behavior and sexual orientation. Enhances male-specific expression of
CC takeout in brain-associated fat body. {ECO:0000269|PubMed:10934470,
CC ECO:0000269|PubMed:12435630, ECO:0000269|PubMed:8790392,
CC ECO:0000269|PubMed:8978612, ECO:0000269|PubMed:9418892}.
CC -!- INTERACTION:
CC Q8IN81-1; Q9VDK5: bon; NbExp=2; IntAct=EBI-6171772, EBI-3406250;
CC Q8IN81-6; Q9VDK5: bon; NbExp=4; IntAct=EBI-6171802, EBI-3406250;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=13;
CC Comment=Sex specific splicing is controlled by tra and tra-2.
CC Sex-specific repression of the translation of fru mRNA might be
CC mediated by the binding of Tra to the fru mRNA in females.
CC {ECO:0000269|PubMed:10934470, ECO:0000269|PubMed:8978612};
CC Name=Male-A {ECO:0000269|PubMed:10934470}; Synonyms=E
CC {ECO:0000303|PubMed:10731132};
CC IsoId=Q8IN81-1; Sequence=Displayed;
CC Name=Female-A {ECO:0000269|PubMed:10934470}; Synonyms=C
CC {ECO:0000303|PubMed:10731132}, L, M;
CC IsoId=Q8IN81-4; Sequence=VSP_050497;
CC Name=Female-B {ECO:0000269|PubMed:10934470}; Synonyms=F
CC {ECO:0000303|PubMed:10731132};
CC IsoId=Q8IN81-7; Sequence=VSP_050497, VSP_050501, VSP_050505;
CC Name=Female-E {ECO:0000269|PubMed:10934470}; Synonyms=H
CC {ECO:0000303|PubMed:10731132};
CC IsoId=Q8IN81-10; Sequence=VSP_050497, VSP_050500, VSP_050506;
CC Name=Female-I {ECO:0000269|PubMed:8978612};
CC IsoId=Q8IN81-3; Sequence=VSP_050497, VSP_050498, VSP_050501,
CC VSP_050505;
CC Name=Male-B {ECO:0000269|PubMed:10934470}; Synonyms=B
CC {ECO:0000303|PubMed:10731132};
CC IsoId=Q8IN81-6; Sequence=VSP_050501, VSP_050505;
CC Name=Male-E {ECO:0000269|PubMed:10934470}; Synonyms=G;
CC IsoId=Q8IN81-12; Sequence=VSP_050500, VSP_050506;
CC Name=Male-I {ECO:0000269|PubMed:8978612};
CC IsoId=Q8IN81-2; Sequence=VSP_050498, VSP_050501, VSP_050505;
CC Name=Type-C {ECO:0000269|PubMed:10934470}; Synonyms=D
CC {ECO:0000303|PubMed:10731132};
CC IsoId=Q8IN81-8; Sequence=VSP_050497, VSP_050499, VSP_050504;
CC Name=Type-D {ECO:0000269|PubMed:10934470}; Synonyms=A
CC {ECO:0000303|PubMed:10731132};
CC IsoId=Q8IN81-9; Sequence=VSP_050497, VSP_050502, VSP_050503;
CC Name=I;
CC IsoId=Q8IN81-13; Sequence=VSP_039397, VSP_039400;
CC Name=J;
CC IsoId=Q8IN81-14; Sequence=VSP_039398, VSP_039399;
CC Name=K;
CC IsoId=Q8IN81-15; Sequence=VSP_039396, VSP_039401, VSP_050500,
CC VSP_050506;
CC -!- TISSUE SPECIFICITY: Expressed in parts of the adult male brain
CC associated with the courtship song and steps of the male courtship.
CC Also expressed in the larval and pupal male mushroom body and optic
CC lobe. Expressed in pupal female optic lobe.
CC {ECO:0000269|PubMed:10934470, ECO:0000269|PubMed:8790392,
CC ECO:0000269|PubMed:8978612}.
CC -!- DISRUPTION PHENOTYPE: Mutant males exhibit bisexual behavior; they
CC court females but are behaviorally sterile so fail to mate and they
CC exhibit vigorous courtship with other fru mutant males.
CC {ECO:0000269|PubMed:8978612}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF039231; AAB96677.1; -; mRNA.
DR EMBL; U72492; AAB92662.1; -; mRNA.
DR EMBL; D84437; BAA12663.1; -; mRNA.
DR EMBL; D84438; BAA12664.1; -; mRNA.
DR EMBL; AF220176; AAG28587.1; -; mRNA.
DR EMBL; AF220177; AAG28588.1; -; mRNA.
DR EMBL; AF220178; AAG28589.1; -; mRNA.
DR EMBL; AF220179; AAG28590.1; -; mRNA.
DR EMBL; AF220180; AAG28591.1; -; mRNA.
DR EMBL; AF220181; AAG28592.1; -; mRNA.
DR EMBL; AE014297; AAF55562.2; -; Genomic_DNA.
DR EMBL; AE014297; AAF55563.2; -; Genomic_DNA.
DR EMBL; AE014297; AAF55564.2; -; Genomic_DNA.
DR EMBL; AE014297; AAF55565.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13774.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13775.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13776.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13777.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65172.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65173.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65174.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65175.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65176.1; -; Genomic_DNA.
DR EMBL; BT024450; ABC86512.1; -; mRNA.
DR EMBL; AY152837; AAN74532.1; -; mRNA.
DR EMBL; AY152838; AAN74533.1; -; mRNA.
DR EMBL; U14403; AAA50838.1; -; Genomic_DNA.
DR RefSeq; NP_001163648.1; NM_001170177.2.
DR RefSeq; NP_524397.2; NM_079673.3. [Q8IN81-7]
DR RefSeq; NP_732344.1; NM_169816.2. [Q8IN81-6]
DR RefSeq; NP_732345.1; NM_169817.2. [Q8IN81-12]
DR RefSeq; NP_732346.1; NM_169818.2. [Q8IN81-10]
DR RefSeq; NP_732347.1; NM_169819.2. [Q8IN81-1]
DR RefSeq; NP_732348.1; NM_169820.2. [Q8IN81-4]
DR RefSeq; NP_732349.1; NM_169821.2. [Q8IN81-9]
DR RefSeq; NP_732350.1; NM_169822.2. [Q8IN81-8]
DR RefSeq; NP_996234.1; NM_206512.2. [Q8IN81-4]
DR RefSeq; NP_996235.1; NM_206513.2. [Q8IN81-4]
DR RefSeq; NP_996236.1; NM_206514.2. [Q8IN81-15]
DR RefSeq; NP_996237.1; NM_206515.2. [Q8IN81-14]
DR RefSeq; NP_996238.1; NM_206516.2. [Q8IN81-13]
DR AlphaFoldDB; Q8IN81; -.
DR SMR; Q8IN81; -.
DR BioGRID; 67237; 36.
DR DIP; DIP-17120N; -.
DR IntAct; Q8IN81; 6.
DR STRING; 7227.FBpp0290499; -.
DR PaxDb; Q8IN81; -.
DR PeptideAtlas; Q8IN81; -.
DR EnsemblMetazoa; FBtr0083640; FBpp0083060; FBgn0004652. [Q8IN81-10]
DR EnsemblMetazoa; FBtr0083641; FBpp0083061; FBgn0004652. [Q8IN81-6]
DR EnsemblMetazoa; FBtr0083642; FBpp0083062; FBgn0004652. [Q8IN81-4]
DR EnsemblMetazoa; FBtr0083643; FBpp0083063; FBgn0004652. [Q8IN81-1]
DR EnsemblMetazoa; FBtr0083644; FBpp0083064; FBgn0004652. [Q8IN81-7]
DR EnsemblMetazoa; FBtr0083645; FBpp0083065; FBgn0004652. [Q8IN81-12]
DR EnsemblMetazoa; FBtr0083646; FBpp0083066; FBgn0004652. [Q8IN81-9]
DR EnsemblMetazoa; FBtr0083647; FBpp0083067; FBgn0004652. [Q8IN81-8]
DR EnsemblMetazoa; FBtr0083648; FBpp0089355; FBgn0004652. [Q8IN81-13]
DR EnsemblMetazoa; FBtr0083649; FBpp0089356; FBgn0004652. [Q8IN81-14]
DR EnsemblMetazoa; FBtr0083650; FBpp0089357; FBgn0004652. [Q8IN81-15]
DR EnsemblMetazoa; FBtr0083651; FBpp0089358; FBgn0004652. [Q8IN81-4]
DR EnsemblMetazoa; FBtr0083652; FBpp0089359; FBgn0004652. [Q8IN81-4]
DR GeneID; 42226; -.
DR KEGG; dme:Dmel_CG14307; -.
DR UCSC; CG14307-RA; d. melanogaster.
DR CTD; 42226; -.
DR FlyBase; FBgn0004652; fru.
DR VEuPathDB; VectorBase:FBgn0004652; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00530000064321; -.
DR HOGENOM; CLU_007991_0_0_1; -.
DR InParanoid; Q8IN81; -.
DR SignaLink; Q8IN81; -.
DR BioGRID-ORCS; 42226; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 42226; -.
DR PRO; PR:Q8IN81; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004652; Expressed in brain and 24 other tissues.
DR ExpressionAtlas; Q8IN81; baseline and differential.
DR Genevisible; Q8IN81; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002118; P:aggressive behavior; IMP:FlyBase.
DR GO; GO:0016199; P:axon midline choice point recognition; IMP:FlyBase.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0021954; P:central nervous system neuron development; IDA:CACAO.
DR GO; GO:0007620; P:copulation; TAS:FlyBase.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0008049; P:male courtship behavior; IMP:FlyBase.
DR GO; GO:0016543; P:male courtship behavior, orientation prior to leg tapping and wing vibration; NAS:FlyBase.
DR GO; GO:0016544; P:male courtship behavior, tapping to detect pheromone; IMP:CACAO.
DR GO; GO:0048065; P:male courtship behavior, veined wing extension; IMP:CACAO.
DR GO; GO:0045433; P:male courtship behavior, veined wing generated song production; IMP:UniProtKB.
DR GO; GO:0016545; P:male courtship behavior, veined wing vibration; IMP:FlyBase.
DR GO; GO:0060179; P:male mating behavior; IMP:FlyBase.
DR GO; GO:0046661; P:male sex differentiation; TAS:FlyBase.
DR GO; GO:0007617; P:mating behavior; IMP:FlyBase.
DR GO; GO:0048047; P:mating behavior, sex discrimination; IMP:FlyBase.
DR GO; GO:0007517; P:muscle organ development; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007530; P:sex determination; IMP:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..955
FT /note="Sex determination protein fruitless"
FT /id="PRO_0000046921"
FT DOMAIN 131..196
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037,
FT ECO:0000305"
FT ZN_FING 918..941
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..53
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..101
FT /note="Missing (in isoform Female-I, isoform Female-A,
FT isoform Type-D, isoform Type-C, isoform Female-B and
FT isoform Female-E)"
FT /evidence="ECO:0000303|PubMed:10934470,
FT ECO:0000303|PubMed:8790392, ECO:0000303|PubMed:8978612"
FT /id="VSP_050497"
FT VAR_SEQ 1..91
FT /note="Missing (in isoform K)"
FT /evidence="ECO:0000305"
FT /id="VSP_039396"
FT VAR_SEQ 1..85
FT /note="Missing (in isoform I)"
FT /evidence="ECO:0000305"
FT /id="VSP_039397"
FT VAR_SEQ 3..51
FT /note="Missing (in isoform J)"
FT /evidence="ECO:0000303|Ref.7"
FT /id="VSP_039398"
FT VAR_SEQ 52..94
FT /note="HAHSHYAALDLQTPHKRNIETDVRAPPPPLPPPPLPLPPASPR -> SRISR
FT NIDSASCLACPTCITCPTGPAFPICHIRRPPLDALPLW (in isoform J)"
FT /evidence="ECO:0000303|Ref.7"
FT /id="VSP_039399"
FT VAR_SEQ 86..94
FT /note="LPLPPASPR -> MLQKNSVRK (in isoform I)"
FT /evidence="ECO:0000305"
FT /id="VSP_039400"
FT VAR_SEQ 92..93
FT /note="SP -> MT (in isoform K)"
FT /evidence="ECO:0000305"
FT /id="VSP_039401"
FT VAR_SEQ 324..336
FT /note="Missing (in isoform Female-I and isoform Male-I)"
FT /evidence="ECO:0000303|PubMed:8978612"
FT /id="VSP_050498"
FT VAR_SEQ 572..766
FT /note="SAALKLHAEDMSTLLTQHALQAADARDEHNDAKQLQLDQTDNIDGRVKCFNI
FT KHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKEAAYHATPPKYR
FT RAVVYAPPHPDEEAASGSGSDIYVDGGYNCEYKCKELNMRAIRCSRQQHMMSHYSPHHP
FT HHRSLIDCPAEAAYSPPVANNQAYL -> VKKSEAFLGSTGNKSMHQMLLHQAVEAQLK
FT SFQLHYQNEGLDSAMHRLLAQQQQHQEQQQQHQQQPHHSLGKSQSPAIPSGSAGGSSRK
FT SGRFRANWLYQFEWLQYDERANTMFCRHCRKWSGELADIRTSFVEGNSNFRLEIVNHHN
FT KCKSHRMCYERELQEQQQHPMPSGSAGGSSKRRSPEIITINVGKNSA (in isoform
FT Type-C)"
FT /evidence="ECO:0000303|PubMed:10934470"
FT /id="VSP_050499"
FT VAR_SEQ 617..796
FT /note="RVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEE
FT MKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYNCEYKCKELNMRAIRCS
FT RQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDLSTYHGHANH
FT QLHQHPPSAT -> SKAWHMRLTFERLSGGCNLHRCKLCGKVVTHIRNHYHVHFPGRFE
FT CPLCRATYTRSDNLRTHCKFKHPMYNPDTRKFDNLMSSSAVGAAATPTASQLAVASQAA
FT MAAAAAAAFNAAQQQQQQQQQQQQHQHQQQQQHQQSQQQQQQQQQSQQQLHALAQQHML
FT QLQPQHHQQQQHNATSE (in isoform Female-E, isoform K and
FT isoform Male-E)"
FT /evidence="ECO:0000303|PubMed:10934470"
FT /id="VSP_050500"
FT VAR_SEQ 617..789
FT /note="RVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEE
FT MKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYNCEYKCKELNMRAIRCS
FT RQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDLSTYHGHANH
FT QLH -> SSARHHLSTPLSTSSSASPPPPPFGMHLSAALKREYHPLHYMAAGNGHNGPS
FT ALGYGNQGSGNAPNSAGGAGSVAGGVGAGGGAGGATGAAGHNSHHTMSYHNMFTPSRDP
FT GTMWRCRSCGKEVTNRWHHFHSHTAQRSMCPYCPATYSRIDTLRSHLRVKHPDRLLKLN
FT SSI (in isoform Female-I, isoform Male-I, isoform Female-B
FT and isoform Male-B)"
FT /evidence="ECO:0000303|PubMed:10934470,
FT ECO:0000303|PubMed:8978612"
FT /id="VSP_050501"
FT VAR_SEQ 617
FT /note="R -> E (in isoform Type-D)"
FT /evidence="ECO:0000303|PubMed:10934470"
FT /id="VSP_050502"
FT VAR_SEQ 618..955
FT /note="Missing (in isoform Type-D)"
FT /evidence="ECO:0000303|PubMed:10934470"
FT /id="VSP_050503"
FT VAR_SEQ 767..955
FT /note="Missing (in isoform Type-C)"
FT /evidence="ECO:0000303|PubMed:10934470"
FT /id="VSP_050504"
FT VAR_SEQ 790..955
FT /note="Missing (in isoform Female-I, isoform Male-I,
FT isoform Female-B and isoform Male-B)"
FT /evidence="ECO:0000303|PubMed:10934470,
FT ECO:0000303|PubMed:8978612"
FT /id="VSP_050505"
FT VAR_SEQ 797..955
FT /note="Missing (in isoform Female-E, isoform K and isoform
FT Male-E)"
FT /evidence="ECO:0000303|PubMed:10934470"
FT /id="VSP_050506"
FT CONFLICT 93
FT /note="P -> PSLQIS (in Ref. 6; ABC86512)"
FT /evidence="ECO:0000305"
FT CONFLICT 107
FT /note="C -> S (in Ref. 8; AAA50838)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="C -> R (in Ref. 3; BAA12664)"
FT /evidence="ECO:0000305"
FT CONFLICT 212..218
FT /note="RGLTDNN -> CANQGSI (in Ref. 8; AAA50838)"
FT /evidence="ECO:0000305"
FT CONFLICT 722..723
FT /note="RA -> QRN (in Ref. 2; AAB92662 and 3; BAA12663/
FT BAA12664)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8IN81-7:650
FT /note="T -> A (in Ref. 3; AAG28589)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8IN81-8:539
FT /note="S -> P (in Ref. 3; AAG28590)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8IN81-8:617
FT /note="H -> R (in Ref. 3; AAG28590)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 955 AA; 102880 MW; E2A6005D5A7FB7B7 CRC64;
MMATSQDYFG NPYALFRGPP TTLRPRESPL GVGHPHGHGH LHSHAHAHGH GHAHSHYAAL
DLQTPHKRNI ETDVRAPPPP LPPPPLPLPP ASPRYNTDQG AMDQQFCLRW NNHPTNLTGV
LTSLLQREAL CDVTLACEGE TVKAHQTILS ACSPYFETIF LQNQHPHPII YLKDVRYSEM
RSLLDFMYKG EVNVGQSSLP MFLKTAESLQ VRGLTDNNNL NYRSDCDKLR DSAASSPTGR
GPSNYTGGLG GAGGVADAMR ESRDSLRSRC ERDLRDELTQ RSSSSMSERS SAAAAAAAAA
AAVAAAGGNV NAAAVALGLT TPTGGERSPS VGSASAAAAA AAVAAAVAAA ANRSASADGC
SDRGSERGTL ERTDSRDDLL QLDYSNKDNN NSNSSSTGGN NNNNNNNNNN SSSNNNNSSS
NRERNNSGER ERERERERER DRDRELSTTP VEQLSSSKRR RKNSSSNCDN SLSSSHQDRH
YPQDSQANFK SSPVPKTGGS TSESEDAGGR HDSPLSMTTS VHLGGGGGNV GAASALSGLS
QSLSIKQELM DAQQQQQHRE HHVALPPDYL PSAALKLHAE DMSTLLTQHA LQAADARDEH
NDAKQLQLDQ TDNIDGRVKC FNIKHDRHPD RELDRNHREH DDDPGVIEEV VVDHVREMEA
GNEHDPEEMK EAAYHATPPK YRRAVVYAPP HPDEEAASGS GSDIYVDGGY NCEYKCKELN
MRAIRCSRQQ HMMSHYSPHH PHHRSLIDCP AEAAYSPPVA NNQAYLASNG AVQQLDLSTY
HGHANHQLHQ HPPSATHPSH SQSSPHYPSA SGAGAGAGSV SVSIAGSASG SATSAPASVA
TSAVSPQPSS SSTGSTSSAA AVAAAAAAAA NRRDHNIDYS TLFVQLSGTL PTLYRCVSCN
KIVSNRWHHA NIHRPQSHEC PVCGQKFTRR DNMKAHCKIK HADIKDRFFS HYVHM
