ID   FRVR_ECOLI              Reviewed;         582 AA.
AC   P32152; Q2M8J4;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Putative frv operon regulatory protein;
DE   Includes:
DE     RecName: Full=Putative phosphotransferase EIIA component;
DE              EC=2.7.1.-;
DE     AltName: Full=Putative PTS system EIIA component;
GN   Name=frvR; Synonyms=yiiH; OrderedLocusNames=b3897, JW3868;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8346018; DOI=10.1093/nar/21.15.3391;
RA   Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. III. DNA sequence of the region
RT   from 87.2 to 89.2 minutes.";
RL   Nucleic Acids Res. 21:3391-3398(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=8019415; DOI=10.1002/pro.5560030309;
RA   Reizer J., Michotey V., Reizer A., Saier M.H. Jr.;
RT   "Novel phosphotransferase system genes revealed by bacterial genome
RT   analysis: unique, putative fructose- and glucoside-specific systems.";
RL   Protein Sci. 3:440-450(1994).
CC   -!- FUNCTION: Could be involved in the regulation of the transcription of
CC       the FRV operon.
CC   -!- DOMAIN: The PTS EIIA type-2 domain may serve a regulatory function,
CC       through its phosphorylation activity.
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DR   EMBL; L19201; AAB03030.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76879.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77412.1; -; Genomic_DNA.
DR   PIR; S40841; S40841.
DR   RefSeq; NP_418333.1; NC_000913.3.
DR   RefSeq; WP_000931299.1; NZ_SSZK01000026.1.
DR   AlphaFoldDB; P32152; -.
DR   SMR; P32152; -.
DR   BioGRID; 4263326; 6.
DR   IntAct; P32152; 1.
DR   STRING; 511145.b3897; -.
DR   PaxDb; P32152; -.
DR   PRIDE; P32152; -.
DR   EnsemblBacteria; AAC76879; AAC76879; b3897.
DR   EnsemblBacteria; BAE77412; BAE77412; BAE77412.
DR   GeneID; 948389; -.
DR   KEGG; ecj:JW3868; -.
DR   KEGG; eco:b3897; -.
DR   PATRIC; fig|1411691.4.peg.2810; -.
DR   EchoBASE; EB1807; -.
DR   eggNOG; COG1762; Bacteria.
DR   eggNOG; COG3711; Bacteria.
DR   HOGENOM; CLU_033613_1_0_6; -.
DR   InParanoid; P32152; -.
DR   OMA; TTACEKQ; -.
DR   PhylomeDB; P32152; -.
DR   BioCyc; EcoCyc:EG11861-MON; -.
DR   PRO; PR:P32152; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00211; PTS_IIA_fru; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.930.10; -; 1.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR016152; PTrfase/Anion_transptr.
DR   InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF08279; HTH_11; 1.
DR   Pfam; PF00359; PTS_EIIA_2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55804; SSF55804; 1.
DR   PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Kinase; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN           1..582
FT                   /note="Putative frv operon regulatory protein"
FT                   /id="PRO_0000087349"
FT   DOMAIN          443..582
FT                   /note="PTS EIIA type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00417"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         505
FT                   /note="Phosphohistidine; by HPr"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   582 AA;  66000 MW;  96F37F10C58C2A10 CRC64;
     MLNERQLKIV DLLEQQPRTP GELAQQTGVS GRTILRDIDY LNFTLNGKAR IFASGSAGYQ
     LEIFERRSFF QLLQKHDNDD RLLALLLLNT FTPRAQLASA LNLPETWVAE RLPRLKQRYE
     RTCCLASRPG LGHFIDETEE KRVILLANLL RKDPFLIPLA GITRDNLQHL STACDNQHRW
     PLMQGDYLSS LILAIYALRN QLTDEWPQYP GDEIKQIVEH SGLFLGDNAV RTLTGLIEKQ
     HQQAQVISAD NVQGLLQRVP GIASLNIIDA QLVENITGHL LRCLAAPVWI AEHRQSSMNN
     LKAAWPAAFD MSLHFITLLR EQLDIPLFDS DLIGLYFACA LERHQNERQP IILLSDQNAI
     ATINQLAIER DVLNCRVIIA RSLSELVAIR EEIEPLLIIN NSHYLLDDAV NNYITVKNII
     TAAGIEQIKH FLATAFIRQQ PERFFSAPGS FHYSNVRGES WQHITRQICA QLVAQHHITA
     DEAQRIIARE GEGENLIVNR LAIPHCWSEQ ERRFRGFFIT LAQPVEVNNE VINHVLIACA
     AADARHELKI FSYLASILCQ HPAEIIAGLT GYEAFMELLH KG