FRY_DROME
ID FRY_DROME Reviewed; 3479 AA.
AC Q9VT28; Q0E8G4; Q8T9A1; Q9BIR5; Q9GPT8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein furry;
GN Name=fry {ECO:0000312|EMBL:AAF50228.2}; ORFNames=CG32045;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAG41424.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND D), FUNCTION, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RC TISSUE=Imaginal disk {ECO:0000269|PubMed:11526084};
RX PubMed=11526084; DOI=10.1242/dev.128.14.2793;
RA Cong J., Geng W., He B., Liu J., Charlton J., Adler P.N.;
RT "The furry gene of Drosophila is important for maintaining the integrity of
RT cellular extensions during morphogenesis.";
RL Development 128:2793-2802(2001).
RN [2] {ECO:0000312|EMBL:AAF50228.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF50228.2}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAL40005.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2555-3479.
RC STRAIN=Berkeley {ECO:0000269|PubMed:12537569};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15479641; DOI=10.1016/j.cell.2004.09.036;
RA Emoto K., He Y., Ye B., Grueber W.B., Adler P.N., Jan L.Y., Jan Y.-N.;
RT "Control of dendritic branching and tiling by the Tricornered-kinase/Furry
RT signaling pathway in Drosophila sensory neurons.";
RL Cell 119:245-256(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129; SER-1838; SER-1841;
RP SER-2357; THR-2842; SER-2845; SER-2851; SER-2853; SER-2999; SER-3001;
RP THR-3004; SER-3018; SER-3019; SER-3025 AND SER-3027, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [7]
RP FUNCTION.
RX PubMed=32022690; DOI=10.7554/elife.52009;
RA Norkett R., Del Castillo U., Lu W., Gelfand V.I.;
RT "Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating
RT microtubule-microtubule sliding.";
RL Elife 9:0-0(2020).
CC -!- FUNCTION: Plays a role in the Trc/fry signaling pathway by promoting
CC trc kinase activity (PubMed:11526084, PubMed:15479641,
CC PubMed:32022690). Plays a key role in maintaining the integrity of
CC polarized cell extensions (arista) during morphogenesis, regulates the
CC actin cytoskeleton (PubMed:11526084). Plays a key role in patterning
CC sensory neuron dendritic fields by promoting avoidance between
CC homologous dendrites as well as by limiting dendritic branching
CC (PubMed:15479641). Together with trc, has a role in regulating
CC microtubule-sliding during neurite outgrowth (PubMed:32022690).
CC {ECO:0000269|PubMed:11526084, ECO:0000269|PubMed:15479641,
CC ECO:0000269|PubMed:32022690}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B {ECO:0000269|PubMed:11526084}; Synonyms=Long
CC {ECO:0000269|PubMed:11526084};
CC IsoId=Q9VT28-1; Sequence=Displayed;
CC Name=D {ECO:0000269|PubMed:11526084}; Synonyms=Short
CC {ECO:0000269|PubMed:11526084};
CC IsoId=Q9VT28-2; Sequence=VSP_052372, VSP_052373;
CC -!- TISSUE SPECIFICITY: Co-expressed with trc in all da neurons in third
CC instar wild-type larvae; axons and dendritic branches.
CC {ECO:0000269|PubMed:15479641}.
CC -!- DEVELOPMENTAL STAGE: Expression is very low in embryonic and early
CC larval stages, increases to be high from third larval instar to adults.
CC {ECO:0000269|PubMed:11526084}.
CC -!- DISRUPTION PHENOTYPE: Flies exhibit branched arista laterals, branched
CC bristles and a strong multiple hair cell phenotype that consists of
CC clusters of epidermal hairs and branched hairs. Dendrites of fry and
CC trc mutants display excessive terminal branching. Branched laterals in
CC mutant pupae arista are due to the splitting of individual laterals
CC during elongation and abnormally shaped actin bundles.
CC {ECO:0000269|PubMed:11526084}.
CC -!- SIMILARITY: Belongs to the furry protein family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL40005.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF310159; AAG41424.1; -; mRNA.
DR EMBL; AF351187; AAK37558.1; -; mRNA.
DR EMBL; AE014296; AAF50228.2; -; Genomic_DNA.
DR EMBL; AE014296; ABI31247.1; -; Genomic_DNA.
DR EMBL; AY069860; AAL40005.1; ALT_INIT; mRNA.
DR RefSeq; NP_729520.1; NM_168357.3. [Q9VT28-1]
DR BioGRID; 64513; 18.
DR IntAct; Q9VT28; 20.
DR STRING; 7227.FBpp0297352; -.
DR iPTMnet; Q9VT28; -.
DR PaxDb; Q9VT28; -.
DR PRIDE; Q9VT28; -.
DR EnsemblMetazoa; FBtr0076417; FBpp0076146; FBgn0016081. [Q9VT28-1]
DR GeneID; 39122; -.
DR KEGG; dme:Dmel_CG32045; -.
DR CTD; 10129; -.
DR FlyBase; FBgn0016081; fry.
DR VEuPathDB; VectorBase:FBgn0016081; -.
DR eggNOG; KOG1825; Eukaryota.
DR GeneTree; ENSGT00610000086058; -.
DR HOGENOM; CLU_000483_0_0_1; -.
DR InParanoid; Q9VT28; -.
DR OMA; HAQQVTI; -.
DR PhylomeDB; Q9VT28; -.
DR SignaLink; Q9VT28; -.
DR BioGRID-ORCS; 39122; 0 hits in 3 CRISPR screens.
DR ChiTaRS; fry; fly.
DR GenomeRNAi; 39122; -.
DR PRO; PR:Q9VT28; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0016081; Expressed in adult hindgut (Drosophila) and 23 other tissues.
DR ExpressionAtlas; Q9VT28; baseline and differential.
DR Genevisible; Q9VT28; DM.
DR GO; GO:0045177; C:apical part of cell; IDA:FlyBase.
DR GO; GO:0030424; C:axon; IDA:FlyBase.
DR GO; GO:0044297; C:cell body; IDA:FlyBase.
DR GO; GO:0005938; C:cell cortex; IDA:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0030425; C:dendrite; IDA:FlyBase.
DR GO; GO:0030427; C:site of polarized growth; IBA:GO_Central.
DR GO; GO:0048800; P:antennal morphogenesis; IMP:FlyBase.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.
DR GO; GO:0070593; P:dendrite self-avoidance; IGI:FlyBase.
DR GO; GO:0035317; P:imaginal disc-derived wing hair organization; IGI:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0051012; P:microtubule sliding; IMP:UniProtKB.
DR GO; GO:0150013; P:negative regulation of neuron projection arborization; IMP:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0035316; P:non-sensory hair organization; IMP:FlyBase.
DR GO; GO:0048601; P:oocyte morphogenesis; IDA:FlyBase.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0050773; P:regulation of dendrite development; IMP:UniProtKB.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0042052; P:rhabdomere development; IMP:FlyBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025614; Cell_morpho_N.
DR InterPro; IPR025481; Cell_Morphogen_C.
DR InterPro; IPR045842; Fry_C.
DR InterPro; IPR039867; Furry/Tao3/Mor2.
DR InterPro; IPR029473; MOR2-PAG1_mid.
DR PANTHER; PTHR12295; PTHR12295; 1.
DR Pfam; PF19421; Fry_C; 2.
DR Pfam; PF14225; MOR2-PAG1_C; 1.
DR Pfam; PF14228; MOR2-PAG1_mid; 5.
DR Pfam; PF14222; MOR2-PAG1_N; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..3479
FT /note="Protein furry"
FT /id="PRO_0000282939"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2125..2185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2337..2375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2829..2859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2901..2936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2982..3079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3460..3479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2125..2168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2355..2375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2829..2856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2901..2933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3003..3018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1838
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1841
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2357
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2842
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2845
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2851
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2853
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2999
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3001
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3004
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3018
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3019
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3025
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3027
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 1624..1629
FT /note="EDDKVG -> GMRFSY (in isoform D)"
FT /evidence="ECO:0000303|PubMed:11526084"
FT /id="VSP_052372"
FT VAR_SEQ 1630..3479
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000303|PubMed:11526084"
FT /id="VSP_052373"
FT CONFLICT 170
FT /note="E -> V (in Ref. 1; AAG41424/AAK37558)"
FT /evidence="ECO:0000305"
FT CONFLICT 1876
FT /note="M -> I (in Ref. 1; AAG41424)"
FT /evidence="ECO:0000305"
FT CONFLICT 1933
FT /note="I -> L (in Ref. 1; AAG41424)"
FT /evidence="ECO:0000305"
FT CONFLICT 2530
FT /note="T -> I (in Ref. 1; AAG41424)"
FT /evidence="ECO:0000305"
FT CONFLICT 3375
FT /note="I -> V (in Ref. 4; AAL40005)"
FT /evidence="ECO:0000305"
FT CONFLICT 3403
FT /note="I -> M (in Ref. 4; AAL40005)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3479 AA; 384352 MW; 281389C02117A0CF CRC64;
MDQLELQDDL FGLEAGVAGT NQNPNEQHLS DPAASPSTSS PANNNATAGA ATTSTATVIT
AVGGAGGGVA AAGVGVVTPT KSPQRNAFQE DAYQANLAGG DSVDNIESAQ LDGGNPSGGS
PGQRHSINSA EYTSTPKTTR SGPNGSTTAS GTTSPINYQL PGDDYPYGIE YESQQLLYQQ
QQQQQQQQSQ QQQQQQQQQQ QQLPVGDVEQ SSAVTYQSLP VSRQSYASPP ALIIPQRQSL
LPWGAHSRSS IINVLPSYTQ AEMHALAARV ASVETSAPRP GEIVMRNLFS DFTAQAEKKI
ELVMLESADK NLSKLLQRGE DQQFDQLLSA LGSVAEHCLP SLLHTLLAWH RRQLSDMEIK
NDLKKPAPSG SSSQAATNKP TVDLDFQLQR REAAVEFIFC LALIEILKQL PYHPGHEDLV
RSIENLAFKH FKYKDGLQNN PNALNIHMIA DLYAEVIGVL AQSRFASVRK RFMSELKELR
GKEVSPTTTQ SIISLLMGMK FFRVKMVPIE EFEASFQFMH ECGQYFLEVK DKDIKHALAG
LFVEILVPVA AAVKNEVNVP CVKNFVELLY VQTLDASTKS KHRLALFPLV TCLLCVSQKT
FFLTNWHYFL AMCLSNLKNR DAKMSRVALE SLFRLLWVYM IRIKCESNSA THSRLQSIVN
SLFPKGSKGV VPRDTPLNIF VKIIQFIAQE RLDFAMREIV YDLLCVGRSI KLILNPERMS
IGLRAFLVVA DSLQQKAGEP PMPRTVPVLP SGNTLRVKKT FNKMYVLLTD DTARSIGMST
YFPHVRRVFV DILRALDVHY GRPLMMTNTQ NQNKEPDEML SGERKPRIDL FRTCVAAVPR
LIPDTMTPHE LVDMLSRLSV HMDEELRILT HQSLTTLVID FPDWRQDVVH GYTQFLVRDV
TDTYPQLLEN CTRILFTFLN IWRCATNVNG NNTTSAPSGA TNVVNTSQAK MTTATTTTTV
VQATVVQVTS APAKDTASSQ LSKQQHLNTA SSAASSITTS SGMSSITQHT VLNMASDVGK
KNEIPLATTL HFVEGFALVL LCNYRTYLRK LAALILKEVK NLMRALGIPE TEPPLIDVMD
RCVPGIIEKC LPQLPQTEKT AILNANCIDL QWIAERSSGV WLAGLTDDNS KSSTSTLNLS
QSSSTPNASA TAASSPQLPF DPWATCLFGL LERQNVLQQC PSAVAQAWPI CFTRLNALYS
VIDPTPVSDN RASLLRSSAP TKKVPTESQK DSYLRLWRNQ VACAMRLVPQ IPSVAVRCAS
PDLSLSSSPD SLNADRSDKS AMGSASPQAL YKLVVPLLRC EVVDVRDAAV NALGLINHDA
LKDLMEELVV YIREAVDCKQ ENMRRRRRRD ALRLQVVRVL EKIAENGTFG VSTCVLERDT
MSLHPTFVLY ISGAMGYLTS ETDKDNLSIR EVKAHFCNFI RKMIKNFPLE ACATLLSRVL
KRNLFNLFAA WCGSFSKPLG YTMQSDHTLE EEKLQFSALQ AMSALLCCGQ IFNPSYLQDD
SIIYKWLDML LTSKNEKIYQ LARDTVVLLL ESNPDIGQLL EWVIDRCYTS TPREADACFL
ALASIFSAKE YPCDHYTSVI TVTLLMTGCP RVEVHATALQ LLQILDKRFF GSVVGTLHSD
SDKEDDKVGT LDVLLSSAYC RSQRFLSKQL AQLRPELTMS IFSEITHRFQ SAREDVRALL
LQCLLPWLQN MELVATSVPP ATPLSYIMYF PDSGTRGRRE GTGSTEATEM ILNNLFYITA
KFSDAHPRDI EELWGTLCQF WPNNLKVILR YLVIMSGMAP TELLPYAKRV ALYLVRSCPD
RLLDELMAEL QTVETLNCLI ERTETPPFYR LTSMRKASSH SADGQAAGGI NDSRIQDLAV
EKGTIHTKRH SGEDPMKIGT CKSDSGIRAY TQAAAAAAAA AVTPGSSGNR PPRGADKIRA
ASGPSILPRP EDILINDPEL RQEENVELRG TSDAAPNGHP HPLPMPEYGG YFAPLTEFLP
DVSLPISGFH RCNVAVMLLT DIVVDGIPGI DWTLHLPLML HILFLGLDHT RIIVREHCKQ
LCVNLLIVLA EHNDHLTVAR ILLNSETSKL DLGLTVPALP VIDNNFTELH QQFDSYLLHV
SPQAAAYALQ HNLSSSTIIA AHHQNLSQTP QSQQQTGSQN GQTTTPPGLT ATPAALQINP
NNSENSEVPL IHPDEHAPPQ PGPSMPIAHV IKSLLKFLAQ DTCQPLWNYE DITAKVWAVK
SAEQLSCFLK HMVKVFADSY PQARIAERWA QTALQLGLSC SSRHYAGRCL QIFRALNVPI
NSRMLSDILS RLVETVAEQG EDMQGYVTEL LLTLEAAVDS LDSDFRPLDV MKDIFKSTPN
LNNKDGGPNS ILPGKKSPSG MTPQSSNYSI PSHGRSTSYS VSYCGRKANN SPCDKQVELR
NRSSGIDLER SVVCKFGVGG GGAGSALSRS RSAQSLKMLG DTATQDDKMT ILAQLFWLSV
SLLESDYEHE FMLALRLLTR VLHRLPLDRP DARDKVEKLQ QQLKWTAYPG VHALLLKGCT
HSATYEPTIT LLSQFAPLLT LPVCDPTQSC AFPMNVIALL PYMLLHYEDA NEICIRSAEN
IAQVSTELGA KLENLGTVMT LYSRKTFCKE SFQWTKCVVK YLHDTYAHMG LHMVAFLIEV
LEKGPQQVQV PVLNVIHCML HYVDLSAPQA QSINADLLRA IGKYLDTAYW KDSLKILKLI
VTRSSSLQVV PPSDGSSAGL SFSFYGAYPD SDMFCKKELA GRTMEFTFDV SQTPLIGRRI
LLKTEEPVAG GAVSTTGSSS LNSTLTNATT VTVAPSAAQQ QTNVQMQQQR ANTNVAALAA
AAAAQHQQQQ HAIGAGSSVV GTPNSPRRSA SLSPADTVPL SGWKRPWMSQ CRVRECLVNL
LTTCGQRVGL PKSPSVIFSQ SSDLMERQSS AASSTEETSG PQGDLSSGSR RDDGQPDFTV
FKDFDFLEYE DSIAGESTDN FNWGVRRHQL FEGDEDRLNC GSGIGGSIKG GHSSAFEDSF
SDKTPILSKR KRQIADDSSD EEAESESPLD EDHRQSFLKS GYSAVPPTSL SLRERRRRNS
VSRSDTSGSS AGDLGDLTPC NASPHLPGII RFSAAIHDEA EENWRRQVQA LLVNQPSAHT
SELLQQLYRL IKELTFKTVN ISKEAKKFFT GIGSQLGNRI SLFTDLLSSR ADPPQVWCSE
LQATSPKLFE TLRFNVLEVQ EHLETFFDRK DQVLECLDAV KTSCKLSLFN EADVAASGLE
LPSTSSIVYM PFDPASTEVV LDLGRSLYKL MFQLLLLIES NHKISSNVVN HFRMNEDMHD
ISDLYALVRD ALVRYISEAE LDCLESSTST EGEHTPTPSP GLPMTPEEFE AVLTEHIDLQ
RWPSAIAHVR QYRRISTLNA SGYQNVTIFS YNSADNRQKW DEISVILNAY AHGIMKDRTE
AFIVSKSDSE VFEIYAILSE NLYQVSSALT NMEISMKSYS AGSASGNSHR SEQDIVTNL
