ID   FRZF_MYXXA              Reviewed;         593 AA.
AC   P31759;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Protein methyltransferase FrzF;
DE            EC=2.1.1.80;
GN   Name=frzF;
OS   Myxococcus xanthus.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=34;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DZF1;
RX   PubMed=2168368; DOI=10.1128/jb.172.9.4877-4887.1990;
RA   McCleary W.R., McBride M.J., Zusman D.R.;
RT   "Developmental sensory transduction in Myxococcus xanthus involves
RT   methylation and demethylation of FrzCD.";
RL   J. Bacteriol. 172:4877-4887(1990).
CC   -!- FUNCTION: This methyltransferase is one of the proteins required for
CC       the normal aggregation of M.xanthus cells during fruiting body
CC       formation. It is also a component of a sensory transduction pathway
CC       that controls the frequency at which cells reverse their gliding
CC       direction. It may methylate FrzCD to form gamma-glutamyl methyl ester
CC       residues.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-
CC         glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311,
CC         ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:82795; EC=2.1.1.80;
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DR   EMBL; M35200; AAA25398.1; -; Genomic_DNA.
DR   PIR; B36707; XYYZFG.
DR   RefSeq; WP_011554141.1; NZ_FNOH01000003.1.
DR   AlphaFoldDB; P31759; -.
DR   SMR; P31759; -.
DR   GeneID; 41361457; -.
DR   OMA; PLCVEAR; -.
DR   GO; GO:0008983; F:protein-glutamate O-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.155.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR022642; CheR_C.
DR   InterPro; IPR000780; CheR_MeTrfase.
DR   InterPro; IPR036804; CheR_N_sf.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF01739; CheR; 1.
DR   PRINTS; PR00996; CHERMTFRASE.
DR   SMART; SM00138; MeTrc; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS50123; CHER; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   4: Predicted;
KW   Chemotaxis; Methyltransferase; Repeat; S-adenosyl-L-methionine; TPR repeat;
KW   Transferase.
FT   CHAIN           1..593
FT                   /note="Protein methyltransferase FrzF"
FT                   /id="PRO_0000176046"
FT   DOMAIN          1..276
FT                   /note="CheR-type methyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00051"
FT   REPEAT          423..456
FT                   /note="TPR 1"
FT   REPEAT          457..490
FT                   /note="TPR 2"
FT   REPEAT          491..524
FT                   /note="TPR 3"
SQ   SEQUENCE   593 AA;  64669 MW;  B38BA5F481A082B9 CRC64;
     MLTASQKVLQ QLAALLLERA GLKITPDGFH SLRLALSARM PVLGLEEPEH YIQRLTGAGG
     EEELRSLLPL VTVGHTEFFR DAKQFRALEK SVLPDLVSRS RREMRKVSIW SAGCATGEEP
     YSLAMVLAEL GALSLEVDLW ATDLNLAAVE AAKQGRFTSR RAISINQARL TRFFKPVEEG
     YEALPALREY IRFDGQNLAV PVFDKVALSS LDLILCRNVI IYFDLPTIRG LMDRFLAALR
     PGGLLFLGYS ESLFKVYDRF EMIEVDGAFV YRRPLNDKSM RAPPLRITPY PGEPDVAARR
     PVPADAFTAD LRKRMLPEDV PLTTRLPAVS ASSVAAPGSP SVTLPALGAS SSPRSVVPGR
     LPAVSPHSPL PAIAARSRVT AELPTVGSVD SARPRITTEL PAVATTPRAP TVEVPAWPTL
     LPPAERLAMA VRKMAQGDFS AAIAGVQRLL ADEPSDLDGL LTLGNLFSLT GRIPEAREAF
     AQAIQREPLC VEARVFGGVA ALQAGELSEA RSELSKALFL EPTLAIGHYL LAQVHERTQD
     HEAARRSYRN AIAQLRFPQR PLAGHYPEMP DSADAISRAA RYALAALEEQ PLR