ID   ALDH_PSESP              Reviewed;         488 AA.
AC   P33008;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Probable aldehyde dehydrogenase;
DE            EC=1.2.1.3;
GN   Name=terPE;
OS   Pseudomonas sp.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1629218; DOI=10.1016/s0021-9258(19)49697-x;
RA   Peterson J.A., Lu J.-Y., Geisselsoder J., Graham-Lorence S., Carmona C.,
RA   Witney F., Lorence M.C.;
RT   "Cytochrome P-450terp. Isolation and purification of the protein and
RT   cloning and sequencing of its operon.";
RL   J. Biol. Chem. 267:14193-14203(1992).
CC   -!- FUNCTION: Involved in an alpha-terpineol oxidation system.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; M91440; AAA25995.1; -; Genomic_DNA.
DR   PIR; C42971; S27652.
DR   AlphaFoldDB; P33008; -.
DR   SMR; P33008; -.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..488
FT                   /note="Probable aldehyde dehydrogenase"
FT                   /id="PRO_0000056452"
FT   ACT_SITE        262
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        296
FT                   /evidence="ECO:0000250"
FT   BINDING         240..245
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   488 AA;  52156 MW;  2144AE1EB173C854 CRC64;
     MSSRESASRR PDPLRVTIMQ SPSAFSLTIG GHGVATSDYL PVLNPATRQP IGQCPVASEE
     HVEQARAAAG DAFAVWRQVP YGKRCEQLQA LAGILEAHLD ELAQLLTHEQ GKPLADARGE
     LAGAIAFCQC AGSLPLPEVV HEQSATRLSK TVREPLGVVV AIVPWNYPVS IAFVKPDRRV
     GCRKHADSQA GADHAADYLR IGELIRDALP AGVINVLAGN DDLGPWLTGH ADVAKISFTG
     SSVTGRHVAR SAAADLKRLT LELGGNDAAV VMADSLSDAV VERVFWSAFT NAGQICMATK
     RLYIHESIYE AFRDKLVAYA QNVVIGDGSQ PGVTMGPLQN AKQFAKVMSL IDAVRQRGGR
     LIECGQMRGG DGYFLPITFV DLPDESAPEV VEEAFGPLLP LLKFRDVDEV IERVNAARTG
     WLAASGVVIG RSAHGLQQPS TRSVWSTTGC DHAVYSFGGM KASGYGAESG LEGLLEFTTQ
     KTVIIQQQ