ID   FSA5_FUSSF              Reviewed;         465 AA.
AC   A0A0E4AY46;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   24-JUN-2015, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Fusarisetin A cluster transcription factor fsa5 {ECO:0000303|PubMed:25770422};
DE   AltName: Full=Fusarisetin A biosynthesis protein 5 {ECO:0000303|PubMed:25770422};
GN   Name=fsa5 {ECO:0000303|PubMed:25770422};
OS   Fusarium sp. (strain FN080326).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=1608308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25770422; DOI=10.1016/j.bbrc.2015.03.011;
RA   Kato N., Nogawa T., Hirota H., Jang J.H., Takahashi S., Ahn J.S., Osada H.;
RT   "A new enzyme involved in the control of the stereochemistry in the decalin
RT   formation during equisetin biosynthesis.";
RL   Biochem. Biophys. Res. Commun. 460:210-215(2015).
CC   -!- FUNCTION: Transcription activator that specifically regulates the
CC       expression of the gene cluster that mediates the biosynthesis of
CC       fusarisetin A (PubMed:25770422). {ECO:0000269|PubMed:25770422}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the transcription of the fusarisetin A
CC       biosynthesis cluster and abolishes fusarisetin A production
CC       (PubMed:25770422). {ECO:0000269|PubMed:25770422}.
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DR   EMBL; LC025956; BAR40287.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0E4AY46; -.
DR   SMR; A0A0E4AY46; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..465
FT                   /note="Fusarisetin A cluster transcription factor fsa5"
FT                   /id="PRO_0000441302"
FT   DNA_BIND        13..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          58..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   465 AA;  50901 MW;  91F637FF73F3A4BC CRC64;
     MSTQNNQSIR SSCDRCRSHK LKCTVAPENT RSGSSRCTRC IRAQVTCVFG HRSQSKRSTN
     VKKADLRSGT NGQETTSMQA STIVPGSPDL WVGRQEVEEG LHIGSDSGPS MADGDLWAEL
     GTNHDLSLFD ITPSSLPTHN SQQQFSATDF CSAPMAPHSA LSTINSQEWQ LDLSEYPNQT
     TTGPHAIVQL SALVAKIHET SRTLEESFWT SLAESNQLKS YPIGRVLSLS QDFSTILECI
     WASKNMDCKQ SLSCAASDNH GQDATSSFEL EDVLDYGELL STVGTSPGRS DFSTSTHSSV
     ATTVDMPTML LVLSCYTSLT KLYSLVFEHF ESHLSHLPHS YTSQTAHASP KWGLGLQLGE
     LPSADETCTK VYTAVQILLD AFQSVEDVVG LPRSLSAVRQ QSCGKEEEGE SGDVFNRASL
     WTDFLAKSVF KATVKSSSEE DCEEIRQLSI KVKSLKSLIR ERMKL