FSBP_MOUSE
ID FSBP_MOUSE Reviewed; 299 AA.
AC Q8BKE5; Q8BJX8;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Fibrinogen silencer-binding protein;
GN Name=Fsbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Eye, and Mesonephros;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Transcriptional repressor that down-regulates the expression
CC of the fibrinogen gamma chain. Represses transcription of GSK3B gene
CC promoter via its interaction with APBA1. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with APBA1 (via PDZ 1 and 2 domains). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BKE5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BKE5-2; Sequence=VSP_010775;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK053419; BAC35379.1; -; mRNA.
DR EMBL; AK078439; BAC37274.1; -; mRNA.
DR CCDS; CCDS57263.1; -. [Q8BKE5-1]
DR RefSeq; NP_001243071.1; NM_001256142.1. [Q8BKE5-1]
DR RefSeq; NP_001243074.1; NM_001256145.1.
DR AlphaFoldDB; Q8BKE5; -.
DR SMR; Q8BKE5; -.
DR BioGRID; 550136; 4.
DR STRING; 10090.ENSMUSP00000137082; -.
DR iPTMnet; Q8BKE5; -.
DR PhosphoSitePlus; Q8BKE5; -.
DR PaxDb; Q8BKE5; -.
DR PRIDE; Q8BKE5; -.
DR ProteomicsDB; 266865; -. [Q8BKE5-1]
DR ProteomicsDB; 266866; -. [Q8BKE5-2]
DR Antibodypedia; 65416; 54 antibodies from 16 providers.
DR Ensembl; ENSMUST00000180239; ENSMUSP00000137082; ENSMUSG00000094595. [Q8BKE5-1]
DR GeneID; 100503583; -.
DR GeneID; 623474; -.
DR KEGG; mmu:100503583; -.
DR UCSC; uc008rzt.2; mouse. [Q8BKE5-1]
DR CTD; 100861412; -.
DR CTD; 25788; -.
DR MGI; MGI:5301008; Fsbp.
DR VEuPathDB; HostDB:ENSMUSG00000094595; -.
DR eggNOG; ENOG502QUKT; Eukaryota.
DR GeneTree; ENSGT00390000008778; -.
DR HOGENOM; CLU_080744_0_0_1; -.
DR OMA; CGYDPQM; -.
DR OrthoDB; 1207901at2759; -.
DR PhylomeDB; Q8BKE5; -.
DR TreeFam; TF331896; -.
DR BioGRID-ORCS; 100503583; 4 hits in 72 CRISPR screens.
DR BioGRID-ORCS; 623474; 3 hits in 111 CRISPR screens.
DR PRO; PR:Q8BKE5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BKE5; protein.
DR Bgee; ENSMUSG00000094595; Expressed in retinal neural layer and 51 other tissues.
DR Genevisible; Q8BKE5; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR042383; FSBP.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR PANTHER; PTHR15386; PTHR15386; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Isopeptide bond; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..299
FT /note="Fibrinogen silencer-binding protein"
FT /id="PRO_0000087353"
FT REGION 189..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 94
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O95073"
FT VAR_SEQ 1..141
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010775"
SQ SEQUENCE 299 AA; 34403 MW; CC0A2936D0642E7E CRC64;
MVGKARSSNF TLSEKLDLLN LVKPYVKILE EHTNKNSVIV EKNRCWDVIA VNYNAIGVDR
PPRTAQGLRS LYKRLKEYAK QELLQQKEAQ SEFKSSVSEP TKQVMEMIPQ IASFGLIRDR
SHIQSANLDE TAQAGTSSLQ VMVDHHPVAI TVEVKQEEDI KPSPPLVSNP QLSDTLEQRE
EHELMHVVEG SESPSLSSVD MRMTSSPSSV PRRDEIFHQE SGEHFRSLLR CDPQVLQMLK
EEHQIILENQ KNFGLYVQEK RDGLRRRQRL EEELLRAKIE VEKLKATRLR RDLPEYSSL
