ID   FSBP_RAT                Reviewed;         298 AA.
AC   D3ZXW3;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Fibrinogen silencer-binding protein;
GN   Name=Fsbp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH APBA1.
RX   PubMed=20531236; DOI=10.1097/wnr.0b013e32833bfca0;
RA   Lau K.F., Perkinton M.S., Rodriguez L., McLoughlin D.M., Miller C.C.;
RT   "An X11alpha/FSBP complex represses transcription of the GSK3beta gene
RT   promoter.";
RL   NeuroReport 21:761-766(2010).
CC   -!- FUNCTION: Transcriptional repressor that down-regulates the expression
CC       of the fibrinogen gamma chain. Represses transcription of GSK3B gene
CC       promoter via its interaction with APBA1 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with APBA1 (via PDZ 1 and 2 domains).
CC       {ECO:0000269|PubMed:20531236}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20531236}.
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DR   EMBL; AABR03043638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473962; EDL98438.1; -; Genomic_DNA.
DR   RefSeq; XP_006225281.1; XM_006225219.3.
DR   RefSeq; XP_006237955.1; XM_006237893.3.
DR   AlphaFoldDB; D3ZXW3; -.
DR   SMR; D3ZXW3; -.
DR   STRING; 10116.ENSRNOP00000020245; -.
DR   PaxDb; D3ZXW3; -.
DR   PRIDE; D3ZXW3; -.
DR   Ensembl; ENSRNOT00000104030; ENSRNOP00000077486; ENSRNOG00000039949.
DR   GeneID; 102550523; -.
DR   KEGG; rno:102550523; -.
DR   CTD; 100861412; -.
DR   eggNOG; ENOG502QUKT; Eukaryota.
DR   GeneTree; ENSGT00940000156966; -.
DR   HOGENOM; CLU_080744_0_0_1; -.
DR   InParanoid; D3ZXW3; -.
DR   OMA; CGYDPQM; -.
DR   OrthoDB; 93727at2759; -.
DR   PhylomeDB; D3ZXW3; -.
DR   TreeFam; TF331896; -.
DR   PRO; PR:D3ZXW3; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Proteomes; UP000234681; Chromosome 5.
DR   Bgee; ENSRNOG00000015004; Expressed in ovary and 15 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   InterPro; IPR042383; FSBP.
DR   InterPro; IPR028002; Myb_DNA-bind_5.
DR   PANTHER; PTHR15386; PTHR15386; 1.
DR   Pfam; PF13873; Myb_DNA-bind_5; 1.
PE   1: Evidence at protein level;
KW   Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..298
FT                   /note="Fibrinogen silencer-binding protein"
FT                   /id="PRO_0000417500"
FT   REGION          191..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        94
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:O95073"
SQ   SEQUENCE   298 AA;  34220 MW;  33420434F6689F43 CRC64;
     MVGKARSSNF TLSEKLDLLN LVKPYVKILE EHTNKNSVIV EKNRCWDVIA VNYNAIGVDR
     PPRTAQGLRS LYKRLKEYAK QELLQQKEAQ SDYKSSISEP TKKVVEMIPQ ISSFCLVRDR
     NHIQSTNLDE AAQAGTSSLQ VMVDHHPVAI TVEVKQEEDI KPSPALVSSP QHNDALEQQE
     EHELMRVAEG SVSPSLSSVD MRMTSSPSSV PRRDVFHQES GEHLRSLLRC DPQVLQMLKE
     EHQLILENQK KFGLYVQEKR DGLKRRQRLE EELLRAKIEV EKLRASRLRR DLPEYSSF