FSCB_DICDI
ID FSCB_DICDI Reviewed; 436 AA.
AC Q54RQ3;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Frizzled/smoothened-like sans CRD protein B;
DE Flags: Precursor;
GN Name=fscB; ORFNames=DDB_G0282989;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000049; EAL65938.1; -; Genomic_DNA.
DR RefSeq; XP_639298.1; XM_634206.1.
DR AlphaFoldDB; Q54RQ3; -.
DR SMR; Q54RQ3; -.
DR PaxDb; Q54RQ3; -.
DR EnsemblProtists; EAL65938; EAL65938; DDB_G0282989.
DR GeneID; 8623869; -.
DR KEGG; ddi:DDB_G0282989; -.
DR dictyBase; DDB_G0282989; fscB.
DR HOGENOM; CLU_036764_0_0_1; -.
DR InParanoid; Q54RQ3; -.
DR OMA; HTISIMF; -.
DR PhylomeDB; Q54RQ3; -.
DR PRO; PR:Q54RQ3; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..436
FT /note="Frizzled/smoothened-like sans CRD protein B"
FT /id="PRO_0000371355"
FT TOPO_DOM 23..74
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..156
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..194
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..343
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..436
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 436 AA; 50900 MW; 652AE0D2B80DCA35 CRC64;
MVINKLILLI LLFFCKISYV FTQKLPDGFC PSPLIYKNST DRISDINRGY QFIGETNCVQ
PCPSLVYSES DWKNFFDASL YGGAISIFCS LFLLITYSPL VNNKHNRHTI SIMFLFSGIF
IMLASNGRVF WNNNEGYFDR ICPEKGRFAR QSDRYCLAMG IFYQFGCLTG MMWWTTLSVD
VWMTIKKIKI SNRQIFYYAC IVNFLAIFLT FIPIARDQYG ASNFGIGCWI LGLWDQVFGF
WAPLGICLTI GCIFITLIMY EIYKATGQIK KKLLLKYYKP LVLIILMFFE FFYMFIFITY
IIDHRNKYND EVAEYIVCIL INSGNPNYDE ICKIKRSIPP AAQFLFFLFS RLMGFEGVIF
YGLTNQTKRI WLRSFWFNNR ISLKFRSSFN ISSSTNSSTN TFEKQTPSHL VDPIDQFDNI
EISNNQNIEL SQIENK
