FSCB_HUMAN
ID FSCB_HUMAN Reviewed; 825 AA.
AC Q5H9T9; Q5H9U7; Q86YI2; Q9H0J3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Fibrous sheath CABYR-binding protein;
GN Name=FSCB; Synonyms=C14orf155;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-423.
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLN-195; PRO-380;
RP SER-409 AND THR-642.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANTS [LARGE SCALE ANALYSIS] ARG-262; LYS-764 AND LEU-775.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in the later stages of fibrous sheath
CC biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L
CC SUMOylation. Binds calcium. {ECO:0000250|UniProtKB:A1EGX6}.
CC -!- SUBUNIT: Interacts with CABYR. Interacts with ROPN1 and ROPN1L; the
CC interaction increases upon spermatozoa capacitation conditions.
CC {ECO:0000250|UniProtKB:A1EGX6}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:A1EGX6}. Note=Localizes to cortex of the fibrous
CC sheath including the surface of the longitudinal columns and ribs of
CC the principal piece of sperm flagella. {ECO:0000250|UniProtKB:A1EGX6}.
CC -!- PTM: Phosphorylated by PKA upon spermatozoa capacitation conditions.
CC {ECO:0000250|UniProtKB:A1EGX6}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB66709.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL136775; CAB66709.1; ALT_INIT; mRNA.
DR EMBL; CR933608; CAI45927.1; -; mRNA.
DR EMBL; CR933626; CAI45935.1; -; mRNA.
DR EMBL; AL356022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039878; AAH39878.1; -; mRNA.
DR CCDS; CCDS9679.1; -.
DR RefSeq; NP_115511.3; NM_032135.3.
DR AlphaFoldDB; Q5H9T9; -.
DR STRING; 9606.ENSP00000344579; -.
DR iPTMnet; Q5H9T9; -.
DR PhosphoSitePlus; Q5H9T9; -.
DR BioMuta; FSCB; -.
DR DMDM; 308153599; -.
DR MassIVE; Q5H9T9; -.
DR PaxDb; Q5H9T9; -.
DR PeptideAtlas; Q5H9T9; -.
DR PRIDE; Q5H9T9; -.
DR ProteomicsDB; 62911; -.
DR Antibodypedia; 10167; 105 antibodies from 15 providers.
DR DNASU; 84075; -.
DR Ensembl; ENST00000340446.5; ENSP00000344579.4; ENSG00000189139.6.
DR GeneID; 84075; -.
DR KEGG; hsa:84075; -.
DR MANE-Select; ENST00000340446.5; ENSP00000344579.4; NM_032135.4; NP_115511.3.
DR UCSC; uc001wvn.4; human.
DR CTD; 84075; -.
DR DisGeNET; 84075; -.
DR GeneCards; FSCB; -.
DR HGNC; HGNC:20494; FSCB.
DR HPA; ENSG00000189139; Tissue enriched (testis).
DR MIM; 611779; gene.
DR neXtProt; NX_Q5H9T9; -.
DR OpenTargets; ENSG00000189139; -.
DR PharmGKB; PA162389023; -.
DR VEuPathDB; HostDB:ENSG00000189139; -.
DR eggNOG; ENOG502S90R; Eukaryota.
DR GeneTree; ENSGT00730000111477; -.
DR HOGENOM; CLU_407057_0_0_1; -.
DR InParanoid; Q5H9T9; -.
DR OMA; EVHFLPA; -.
DR OrthoDB; 341336at2759; -.
DR PhylomeDB; Q5H9T9; -.
DR TreeFam; TF336897; -.
DR PathwayCommons; Q5H9T9; -.
DR BioGRID-ORCS; 84075; 4 hits in 1065 CRISPR screens.
DR GenomeRNAi; 84075; -.
DR Pharos; Q5H9T9; Tdark.
DR PRO; PR:Q5H9T9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q5H9T9; protein.
DR Bgee; ENSG00000189139; Expressed in sperm and 25 other tissues.
DR Genevisible; Q5H9T9; HS.
DR GO; GO:0035686; C:sperm fibrous sheath; IBA:GO_Central.
DR GO; GO:0097228; C:sperm principal piece; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0033234; P:negative regulation of protein sumoylation; ISS:UniProtKB.
DR InterPro; IPR043375; FSCB.
DR PANTHER; PTHR36135; PTHR36135; 3.
PE 2: Evidence at transcript level;
KW Calcium; Cell projection; Cilium; Flagellum; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..825
FT /note="Fibrous sheath CABYR-binding protein"
FT /id="PRO_0000089952"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..674
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1EGX6"
FT VARIANT 119
FT /note="P -> S (in dbSNP:rs36083807)"
FT /id="VAR_056874"
FT VARIANT 195
FT /note="H -> Q (in dbSNP:rs3809429)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056875"
FT VARIANT 262
FT /note="T -> R (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035678"
FT VARIANT 380
FT /note="L -> P (in dbSNP:rs3825630)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056876"
FT VARIANT 409
FT /note="P -> S (in dbSNP:rs1959379)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056877"
FT VARIANT 423
FT /note="D -> E (in dbSNP:rs3825632)"
FT /evidence="ECO:0000269|PubMed:11230166"
FT /id="VAR_056878"
FT VARIANT 642
FT /note="A -> T (in dbSNP:rs8009274)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056879"
FT VARIANT 764
FT /note="Q -> K (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035679"
FT VARIANT 775
FT /note="S -> L (in a breast cancer sample; somatic mutation;
FT dbSNP:rs201017166)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035680"
FT CONFLICT 14
FT /note="K -> M (in Ref. 1; CAI45927)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="N -> S (in Ref. 1; CAI45927)"
FT /evidence="ECO:0000305"
FT CONFLICT 39
FT /note="G -> S (in Ref. 1; CAI45935)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="Q -> R (in Ref. 1; CAI45927)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="P -> L (in Ref. 3; AAH39878)"
FT /evidence="ECO:0000305"
FT CONFLICT 672
FT /note="P -> PPPAEEAPSEVQP (in Ref. 1; CAB66709/CAI45927/
FT CAI45935)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 825 AA; 87956 MW; AB9D64A8B40F4EC6 CRC64;
MVGKSQQTDV IEKKKHMAIP KSSSPKATHR IGNTSGSKGS YSAKAYESIR VSSELQQTWT
KRKHGQEMTS KSLQTDTIVE EKKEVKLVEE TVVPEEKSAD VREAAIELPE SVQDVEIPPN
IPSVQLKMDR SQQTSRTGYW TMMNIPPVEK VDKEQQTYFS ESEIVVISRP DSSSTKSKED
ALKHKSSGKI FASEHPEFQP ATNSNEEIGQ KNISRTSFTQ ETKKGPPVLL EDELREEVTV
PVVQEGSAVK KVASAEIEPP STEKFPAKIQ PPLVEEATAK AEPRPAEETH VQVQPSTEET
PDAEAATAVA ENSVKVQPPP AEEAPLVEFP AEIQPPSAEE SPSVELLAEI LPPSAEESPS
EEPPAEILPP PAEKSPSVEL LGEIRSPSAQ KAPIEVQPLP AEGALEEAPA KVEPPTVEET
LADVQPLLPE EAPREEAREL QLSTAMETPA EEAPTEFQSP LPKETTAEEA SAEIQLLAAT
EPPADETPAE ARSPLSEETS AEEAHAEVQS PLAEETTAEE ASAEIQLLAA IEAPADETPA
EAQSPLSEET SAEEAPAEVQ SPSAKGVSIE EAPLELQPPS GEETTAEEAS AAIQLLAATE
ASAEEAPAEV QPPPAEEAPA EVQPPPAEEA PAEVQPPPAE EAPAEVQPPP AEEAPAEVQP
PPAEEAPAEV QPPPAEEAPA EVQSLPAEET PIEETLAAVH SPPADDVPAE EASVDKHSPP
ADLLLTEEFP IGEASAEVSP PPSEQTPEDE ALVENVSTEF QSPQVAGIPA VKLGSVVLEG
EAKFEEVSKI NSVLKDLSNT NDGQAPTLEI ESVFHIELKQ RPPEL
