FSCB_RAT
ID FSCB_RAT Reviewed; 812 AA.
AC Q4V7A4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Fibrous sheath CABYR-binding protein;
GN Name=Fscb {ECO:0000250|UniProtKB:Q5H9T9};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH98054.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-812.
RC STRAIN=Brown Norway {ECO:0000312|EMBL:AAH98054.1};
RC TISSUE=Testis {ECO:0000312|EMBL:AAH98054.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-133, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May be involved in the later stages of fibrous sheath
CC biogenesis. Binds calcium (By similarity).
CC {ECO:0000250|UniProtKB:A1EGX6}.
CC -!- SUBUNIT: Interacts with CABYR. {ECO:0000250|UniProtKB:A1EGX6}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:A1EGX6}. Note=Localizes to cortex of the fibrous
CC sheath including the surface of the longitudinal columns and ribs of
CC the principal piece of sperm flagella. {ECO:0000250|UniProtKB:A1EGX6}.
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DR EMBL; AABR03049340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC098054; AAH98054.1; -; mRNA.
DR RefSeq; NP_001258036.1; NM_001271107.1.
DR AlphaFoldDB; Q4V7A4; -.
DR STRING; 10116.ENSRNOP00000051161; -.
DR iPTMnet; Q4V7A4; -.
DR PhosphoSitePlus; Q4V7A4; -.
DR PaxDb; Q4V7A4; -.
DR PRIDE; Q4V7A4; -.
DR GeneID; 500659; -.
DR KEGG; rno:500659; -.
DR UCSC; RGD:1561721; rat.
DR CTD; 84075; -.
DR RGD; 1561721; Fscb.
DR eggNOG; ENOG502S90R; Eukaryota.
DR HOGENOM; CLU_407057_0_0_1; -.
DR InParanoid; Q4V7A4; -.
DR OMA; EVHFLPA; -.
DR OrthoDB; 341336at2759; -.
DR PhylomeDB; Q4V7A4; -.
DR TreeFam; TF336897; -.
DR PRO; PR:Q4V7A4; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000032241; Expressed in testis.
DR GO; GO:0035686; C:sperm fibrous sheath; ISO:RGD.
DR GO; GO:0097228; C:sperm principal piece; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; ISO:RGD.
DR GO; GO:0033234; P:negative regulation of protein sumoylation; ISS:UniProtKB.
DR InterPro; IPR043375; FSCB.
DR PANTHER; PTHR36135; PTHR36135; 1.
PE 1: Evidence at protein level;
KW Calcium; Cell projection; Cilium; Flagellum; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..812
FT /note="Fibrous sheath CABYR-binding protein"
FT /id="PRO_0000331226"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1EGX6"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1EGX6"
FT MOD_RES 125
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 133
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1EGX6"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1EGX6"
SQ SEQUENCE 812 AA; 88050 MW; 019A0B0BAD1CAB62 CRC64;
MEESDEPEQP ISLGRQEYRR RRLPSQPMVD KSQQTEIGEK KKGMAAVQPP APKATHSIGN
IPGGKANYSG KEYESLILSS QLQQTWMKRK QGQEMTDKSF QTDTSVEEKV EVIFMDKALE
ENSASVGEIA PASPQGVSEV EIPTSRPPSL LIDRAQQTSC TGDWSLISIC SKDKVDKEQQ
TYFSELETTV KSMPGSSLIK SKEETVPIAE DGSLVEIDGS LEIEVLSTEK IPDVVMSFTE
GEISGELQAV PDDEATVKAE HFFTEETSIQ APSLAKETSA AETTAKTPKE FVDIQALPAD
ELSSTEPPAD IRPPLVKGTL SEEPSDQQYP KGTVVAPSEL PVEDLVPLSE EVLEKVQALA
IDTILDDSGR AESTTVEEAT GEVQPPLSEE ITKEVPAEVH LPIATHSKEI VIIIDKEFAI
DEDFEDQPPF ITEVAEDEAT AEVQPPSAED APEEVAPSEV LPPPTEQGTV EHMTAEVLSP
STEVGPAEVP PLPTEEWPLP PVTEESPAEV TPPETEEGPI EPAEEGPEDG LLLPTEEIPS
EVQPPSLEKV PLEEVVIPQA EEVPLDDLPI EVQPLPAENI AGWVPDEFQA FPVDEYPARE
DTVEVQPSSL ESAPIEESSV EAQLLAAEAD TAEIEETPTE VAPAEDQLLP AEEVVLKVEV
ATAWSPLSEL PPAEEATVEA QLTSVEESLK RTSVDVQPPP LDTLAEESPA VKQPLKTDVV
PMPEFPGEEM TAQDPLPPSV KTTVDQDLLK EHQLPEIADI SQVKLEYTTF TGDKKSKGTD
SVPEDVTGIK DDQISTFKIE GTIKIELKNS TS
