FSCC_DICDI
ID FSCC_DICDI Reviewed; 511 AA.
AC Q1ZXA7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Frizzled/smoothened-like sans CRD protein C;
DE Flags: Precursor;
GN Name=fscC; ORFNames=DDB_G0292204;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000187; EAS66815.1; -; Genomic_DNA.
DR RefSeq; XP_001134498.1; XM_001134498.1.
DR AlphaFoldDB; Q1ZXA7; -.
DR SMR; Q1ZXA7; -.
DR STRING; 44689.DDB0231626; -.
DR PaxDb; Q1ZXA7; -.
DR EnsemblProtists; EAS66815; EAS66815; DDB_G0292204.
DR GeneID; 8628541; -.
DR KEGG; ddi:DDB_G0292204; -.
DR dictyBase; DDB_G0292204; fscC.
DR eggNOG; ENOG502RE4K; Eukaryota.
DR HOGENOM; CLU_036764_0_0_1; -.
DR InParanoid; Q1ZXA7; -.
DR OMA; RQLWDIE; -.
DR PhylomeDB; Q1ZXA7; -.
DR PRO; PR:Q1ZXA7; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..511
FT /note="Frizzled/smoothened-like sans CRD protein C"
FT /id="PRO_0000371356"
FT TOPO_DOM 26..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..253
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..357
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..511
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 430..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 511 AA; 57587 MW; 02CC90387A6CFE25 CRC64;
MNQINKFIKN LYLIIITIIL IIVISNDNNG LFINGQSLPD GFCPQPLIYR NSTNRKADID
NGYNFVGETN CLLPCPSPLF PKSQWESYFE MSLIMGSISM FASLFLIITY SPLINKKHTR
HTVGILCMSI GIFFVMVSDG RQLWDIESPG EYKKYCPDTG RYARQSDTKC LTTGLFFQFG
CVTAIGWWSI LAVDLWMTIA KKVQTTKKQL LYYLIGINTV SLILTFGPVV KNQYGFGNAA
IGCWMLDLKY QYGFFWIPVG ICLSVGSVFI GLIFWEIYKI SDAVKKRYLK KHIKPLCLIV
LMCLEFLYMF IYYSYITANQ PTYNKHVAEY IMCLIINAAN VPGSYTCQLK TVSPTAQFLF
LIAIRLMGLQ GLIFYGLTAA TKKVWANSWI YKDLLKLFKL FTTKLYNDSS SEEVENSNYS
NNNSNYYSSN GYTTGGSDNG VGSGRSDKFT KSSSNGGAQD NNNNNNNNNN NNNNNNNNNN
NNNNNSSSLE ISGVESNNST PRVNSPDNLQ P
