FSCF_DICDI
ID FSCF_DICDI Reviewed; 456 AA.
AC Q1ZXB0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Frizzled/smoothened-like sans CRD protein F;
DE Flags: Precursor;
GN Name=fscF; ORFNames=DDB_G0292064;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000187; EAS66812.1; -; Genomic_DNA.
DR RefSeq; XP_001134495.1; XM_001134495.1.
DR AlphaFoldDB; Q1ZXB0; -.
DR SMR; Q1ZXB0; -.
DR STRING; 44689.DDB0231719; -.
DR PaxDb; Q1ZXB0; -.
DR EnsemblProtists; EAS66812; EAS66812; DDB_G0292064.
DR GeneID; 8628485; -.
DR KEGG; ddi:DDB_G0292064; -.
DR dictyBase; DDB_G0292064; fscF.
DR eggNOG; ENOG502RF6Q; Eukaryota.
DR HOGENOM; CLU_036764_0_0_1; -.
DR InParanoid; Q1ZXB0; -.
DR OMA; NIRPLIC; -.
DR PhylomeDB; Q1ZXB0; -.
DR PRO; PR:Q1ZXB0; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..456
FT /note="Frizzled/smoothened-like sans CRD protein F"
FT /id="PRO_0000371359"
FT TOPO_DOM 31..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..297
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..456
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 403..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 456 AA; 52173 MW; FB1AADF0A7C8D8F6 CRC64;
MIFNNLKNQN KIINFLIIFY FLSFLKQIES QSINITSSSS SWQCRGDLVY RNVSNRIEDE
KIGFNFVQYN GTYQSCVIPC PSPFFTINEW NKFLNMSLVM GTISFFSGLF LLVTYSPIVN
KTHNRHTIGV MCMSFGVCLA MCSDMWNFGS NFTEKSICPS PGQYLSTSNA RCLSSGIFLQ
FGGVFGFLNW TLLSFDLFMN IKGIITKNYD KYYVSGTFII AIIFTFVPIV NDQYSMSYIG
LGCWLGSAMY QLIFFWILLS ICLIVSSVFI ILILKEVYII IKLSKQKTSL KGNIRPLICI
SITGFAFFYM FFYYISIVVE GDYYERVLNE YTDCLMDPTK DISECKSPRM SVASEFVFLL
CLRLLGIGAF IFYGINNKVK KIWLNSYWFN NSFVEKYISR KSADNDKSNS NGSKVLYRTN
NTNNNGSFNT GLESSIIEMS TNSNKEESSL NSVDEI
