FSCG_DICDI
ID FSCG_DICDI Reviewed; 453 AA.
AC Q54DR6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Frizzled/smoothened-like sans CRD protein G;
DE Flags: Precursor;
GN Name=fscG; ORFNames=DDB_G0292156;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000187; EAL61434.1; -; Genomic_DNA.
DR RefSeq; XP_629806.1; XM_629804.1.
DR AlphaFoldDB; Q54DR6; -.
DR SMR; Q54DR6; -.
DR PaxDb; Q54DR6; -.
DR EnsemblProtists; EAL61434; EAL61434; DDB_G0292156.
DR GeneID; 8628487; -.
DR KEGG; ddi:DDB_G0292156; -.
DR dictyBase; DDB_G0292156; fscG.
DR eggNOG; ENOG502RF6Q; Eukaryota.
DR HOGENOM; CLU_036764_0_0_1; -.
DR InParanoid; Q54DR6; -.
DR PhylomeDB; Q54DR6; -.
DR PRO; PR:Q54DR6; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..453
FT /note="Frizzled/smoothened-like sans CRD protein G"
FT /id="PRO_0000371360"
FT TOPO_DOM 25..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..352
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 374..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 453 AA; 52054 MW; 6FEC85D6953CCA49 CRC64;
MIYILKNFII ILFFLLIILK RIESQSLPSL PSPTIYKSSQ CRGDLVYRNV SNRMEDEKIG
FTFVQYNGTY QSCVIPCPSP FFTLDEWNKF LYMSLVMGTI SFLCGLFLLI TYSPIVNKTH
NRHTIGVMCM SFGVCLAMCS DMWNFGSNFT DQKSICPSPG QYLTTSNSRC LGSGIVLQFG
GVFGFLNWTL LSFDLFMNIK GIITKNYDKY YFVATFIIAI IFTFVPIVND QYSMSYIGLG
CWLGSAVYQL IFFWILLSIC LIVSSVFIIL ILKEIYIIIK QSKQKTSLKG NIRPLLCITV
TSFAFFYMFF YYISIVIEGD YYERILNEYT DCLMDPTKDV SECKFPRMSV ANEFVFLLCL
RLLGIGAFIF YGINKEVKKI WLNSFWFNNS FVGKYIGSKR SMGNDITNSY ASKAYSKNYN
NNNSINSYNS GLELSIIDMS CNKDDNFKPI IIK
