FSCH_DICDI
ID FSCH_DICDI Reviewed; 533 AA.
AC Q54DP3;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Frizzled/smoothened-like sans CRD protein H;
DE Flags: Precursor;
GN Name=fscH; ORFNames=DDB_G0292100;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000187; EAL61406.1; -; Genomic_DNA.
DR RefSeq; XP_629829.1; XM_629827.1.
DR AlphaFoldDB; Q54DP3; -.
DR SMR; Q54DP3; -.
DR PaxDb; Q54DP3; -.
DR EnsemblProtists; EAL61406; EAL61406; DDB_G0292100.
DR GeneID; 8628510; -.
DR KEGG; ddi:DDB_G0292100; -.
DR dictyBase; DDB_G0292100; fscH.
DR eggNOG; ENOG502REBT; Eukaryota.
DR HOGENOM; CLU_036764_0_0_1; -.
DR InParanoid; Q54DP3; -.
DR OMA; FALGCWI; -.
DR PhylomeDB; Q54DP3; -.
DR PRO; PR:Q54DP3; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Coiled coil; Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..533
FT /note="Frizzled/smoothened-like sans CRD protein H"
FT /id="PRO_0000371361"
FT TOPO_DOM 22..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..177
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..360
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..533
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 454..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 501..528
FT /evidence="ECO:0000255"
FT COMPBIAS 461..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 533 AA; 60836 MW; 3080F4E06CA1DBCC CRC64;
MFIKFYFFII FLILNFKNNY ASPTLLDSVL SSTSSLSSPG SFFIETEFCP PPLLYRYSSD
LEGDKGRGYK YVEFPNGTMS HCVHPCPSLY FSDGDWTTMM DMSLIVATIS FFASIFLILT
YSPLMNPSYN NRHTIGILSM SFGIFLIMFT DMYNLKKRFT LGCPSETRYA IQNDADCLIT
GLIFQFGCVS AVFFWTALSL DLYFQITNRN ISRKYDLYYF IGVNLISLIF TFVPVISKSY
GYGDFALGCW ILDFNYALGC FWIPLSVCLI FSTVVVLMIL YEVYKIYKAS NQKTSLKGHI
KPLLCLISNC FEFFYVFGYS LYLATKLTEL HDNMDAYIKC LFLNSQNDPD SYTCPDHRLK
LGPQFLFFLS LRLLGVSGIV FYGTNSKVRK IWKNSILINN RFIGKYFSFN SGTSTPVGSK
NRSKTSSQLY DNSFGDSGIL EEIREYDEKV KNGIIVTPGG DDDNINNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN SNENNENNTQ EIELTNINTI DNV
