FSCJ_DICDI
ID FSCJ_DICDI Reviewed; 407 AA.
AC Q54DP2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Frizzled/smoothened-like sans CRD protein J;
DE Flags: Precursor;
GN Name=fscJ; ORFNames=DDB_G0292102;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000187; EAL61407.1; -; Genomic_DNA.
DR RefSeq; XP_629830.1; XM_629828.1.
DR AlphaFoldDB; Q54DP2; -.
DR SMR; Q54DP2; -.
DR PaxDb; Q54DP2; -.
DR EnsemblProtists; EAL61407; EAL61407; DDB_G0292102.
DR GeneID; 8628511; -.
DR KEGG; ddi:DDB_G0292102; -.
DR dictyBase; DDB_G0292102; fscJ.
DR eggNOG; ENOG502RC52; Eukaryota.
DR HOGENOM; CLU_036764_0_0_1; -.
DR InParanoid; Q54DP2; -.
DR OMA; IWILNIV; -.
DR PhylomeDB; Q54DP2; -.
DR PRO; PR:Q54DP2; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Coiled coil; Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..407
FT /note="Frizzled/smoothened-like sans CRD protein J"
FT /id="PRO_0000371362"
FT TOPO_DOM 24..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..120
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..169
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..246
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 346
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 407 AA; 46149 MW; C17507BF9FD68938 CRC64;
MKFLFSVILV IISFLGISKI VNGQIACPSP FLYRATNDTV GDYDLGYQYI NIGKPLPPQL
SFLNNCLMPC QSSFFEQDSW NSFNKLVKQM GAVAFTCSAI IMIIYGPLMN RSFFKFDRHT
ITVFCFALST FFIGVSDLMF ATNDVDMVCP ESHRYARQTD KTCATNGVLF QFGWLGSVMW
FAFLSIDGFF RASGKKMNKI AFAIVLASIW ILNIVLSFAP MGGDQYGAYF VGQVNCWILV
KNWQYAFFWA ELIVSLAIGF VGICLTIYSL IRKTSDGNTL KHVTPLILVF LLFCQYLYMI
IFYGIINEKK DHYQNILAEQ VGCIFNNALA KMKVPGIVYA GECTFNETIT FSSQYAFLFF
VRLLGIEIFA FYLFSKETLL LIKSSYIATM FGLGDKDAYD VELEETD
