ID   FSCN2_BOVIN             Reviewed;         492 AA.
AC   O18728;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Fascin-2;
DE   AltName: Full=Retinal fascin;
GN   Name=FSCN2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=9315724; DOI=10.1016/s0014-5793(97)01021-1;
RA   Saishin Y., Shimada S., Morimura H., Sato K., Ishimoto I., Tano Y.,
RA   Tohyama M.;
RT   "Isolation of a cDNA encoding a photoreceptor cell-specific actin-bundling
RT   protein: retinal fascin.";
RL   FEBS Lett. 414:381-386(1997).
CC   -!- FUNCTION: Acts as an actin bundling protein. May play a pivotal role in
CC       photoreceptor cell-specific events, such as disk morphogenesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC       projection, stereocilium {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in the eye, specifically in
CC       photoreceptor cells.
CC   -!- SIMILARITY: Belongs to the fascin family. {ECO:0000305}.
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DR   EMBL; AB003485; BAA22637.1; -; mRNA.
DR   RefSeq; NP_788806.1; NM_176633.3.
DR   AlphaFoldDB; O18728; -.
DR   SMR; O18728; -.
DR   STRING; 9913.ENSBTAP00000034620; -.
DR   PaxDb; O18728; -.
DR   Ensembl; ENSBTAT00000034735; ENSBTAP00000034620; ENSBTAG00000024932.
DR   GeneID; 337926; -.
DR   KEGG; bta:337926; -.
DR   CTD; 25794; -.
DR   VEuPathDB; HostDB:ENSBTAG00000024932; -.
DR   VGNC; VGNC:29127; FSCN2.
DR   eggNOG; ENOG502QPRX; Eukaryota.
DR   GeneTree; ENSGT00950000183157; -.
DR   HOGENOM; CLU_030960_2_0_1; -.
DR   InParanoid; O18728; -.
DR   OMA; IICGAEK; -.
DR   OrthoDB; 1419861at2759; -.
DR   TreeFam; TF323992; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000024932; Expressed in retina and 21 other tissues.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:0042462; P:eye photoreceptor cell development; IEA:Ensembl.
DR   CDD; cd00257; Fascin; 4.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010431; Fascin.
DR   InterPro; IPR022768; Fascin-domain.
DR   InterPro; IPR024703; Fascin_metazoans.
DR   InterPro; IPR030144; FSCN2.
DR   PANTHER; PTHR10551; PTHR10551; 1.
DR   PANTHER; PTHR10551:SF24; PTHR10551:SF24; 1.
DR   Pfam; PF06268; Fascin; 4.
DR   PIRSF; PIRSF005682; Fascin; 1.
DR   SUPFAM; SSF50405; SSF50405; 4.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell projection; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..492
FT                   /note="Fascin-2"
FT                   /id="PRO_0000219381"
SQ   SEQUENCE   492 AA;  55073 MW;  02B772A70ECD13C3 CRC64;
     MPTNGLHQVL KIQFGLVNDT DRYLTAESFG FKVNASAPSL KRKQMWVLEP DPGEGTAVLF
     RSSHLGRYLS AEEDGRVACE AERPGRDCRF LVLPQPDGRW VLQSEPHGRF FGGTEDQLSC
     FATAITPAEL WTVHLAIHPQ AHLLSVSRRR YAHLCPQEDE IAADSNTPWG VDALVTLIFQ
     NRQYCLKSCD SRYLRSDGRL VWEPEARARY TLEFKAGKLA FKDCDGHYLA PVGPAGTLRA
     GRNTRPGKDE LFDLEESHPQ VVLVAANHRY VSVRQGVNVS ANQDEELDHE TFLMQIDQET
     KKCTFYSSTG GYWTLVTHGG IQATATQVSE NTMFEMEWRG RRVALKASNG RYVCMKKNGQ
     LAAISDFVGE DEEFTLKLIN RPILVLRGLD GFVCHRRGSN QLDTNRSVYD VFHLSFSDGA
     YQIRGRGGGF WHTGSHGSVC SDGERAEDFL FEFRERGRLA IRARSGKYLR GGASGLLRAD
     ADAPAGVALW EY