ID   FSCN3_MOUSE             Reviewed;         498 AA.
AC   Q9QXW4; Q80YU6;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Fascin-3;
DE   AltName: Full=Testis fascin;
GN   Name=Fscn3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=11925108; DOI=10.1006/excr.2002.5486;
RA   Tubb B., Mulholland D.J., Vogl W., Lan Z.J., Niederberger C., Cooney A.,
RA   Bryan J.;
RT   "Testis fascin (FSCN3): a novel paralog of the actin-bundling protein
RT   fascin expressed specifically in the elongate spermatid head.";
RL   Exp. Cell Res. 275:92-109(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acts as an actin bundling protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis.
CC   -!- SIMILARITY: Belongs to the fascin family. {ECO:0000305}.
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DR   EMBL; AF176024; AAF19797.1; -; mRNA.
DR   EMBL; CH466533; EDL13800.1; -; Genomic_DNA.
DR   EMBL; BC050759; AAH50759.1; -; mRNA.
DR   CCDS; CCDS39446.1; -.
DR   RefSeq; NP_062515.2; NM_019569.2.
DR   AlphaFoldDB; Q9QXW4; -.
DR   SMR; Q9QXW4; -.
DR   STRING; 10090.ENSMUSP00000031719; -.
DR   PhosphoSitePlus; Q9QXW4; -.
DR   PaxDb; Q9QXW4; -.
DR   PRIDE; Q9QXW4; -.
DR   ProteomicsDB; 271809; -.
DR   Antibodypedia; 45993; 157 antibodies from 22 providers.
DR   DNASU; 56223; -.
DR   Ensembl; ENSMUST00000031719; ENSMUSP00000031719; ENSMUSG00000029707.
DR   GeneID; 56223; -.
DR   KEGG; mmu:56223; -.
DR   UCSC; uc009bcr.1; mouse.
DR   CTD; 29999; -.
DR   MGI; MGI:1890386; Fscn3.
DR   VEuPathDB; HostDB:ENSMUSG00000029707; -.
DR   eggNOG; ENOG502QSD9; Eukaryota.
DR   GeneTree; ENSGT00950000183157; -.
DR   HOGENOM; CLU_030960_1_0_1; -.
DR   InParanoid; Q9QXW4; -.
DR   OMA; QPDCIQL; -.
DR   OrthoDB; 1419861at2759; -.
DR   PhylomeDB; Q9QXW4; -.
DR   TreeFam; TF323992; -.
DR   BioGRID-ORCS; 56223; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q9QXW4; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q9QXW4; protein.
DR   Bgee; ENSMUSG00000029707; Expressed in seminiferous tubule of testis and 15 other tissues.
DR   Genevisible; Q9QXW4; MM.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0031253; C:cell projection membrane; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0030175; C:filopodium; IBA:GO_Central.
DR   GO; GO:0030426; C:growth cone; IBA:GO_Central.
DR   GO; GO:0030027; C:lamellipodium; IBA:GO_Central.
DR   GO; GO:0005902; C:microvillus; IBA:GO_Central.
DR   GO; GO:0001726; C:ruffle; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:0007286; P:spermatid development; TAS:MGI.
DR   CDD; cd00257; Fascin; 3.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010431; Fascin.
DR   InterPro; IPR022768; Fascin-domain.
DR   InterPro; IPR024703; Fascin_metazoans.
DR   InterPro; IPR030143; FSCN3.
DR   PANTHER; PTHR10551; PTHR10551; 1.
DR   PANTHER; PTHR10551:SF1; PTHR10551:SF1; 1.
DR   Pfam; PF06268; Fascin; 2.
DR   PIRSF; PIRSF005682; Fascin; 1.
DR   SUPFAM; SSF50405; SSF50405; 4.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..498
FT                   /note="Fascin-3"
FT                   /id="PRO_0000219384"
FT   CONFLICT        238
FT                   /note="Q -> A (in Ref. 1; AAF19797)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   498 AA;  56443 MW;  C377EE05825BA529 CRC64;
     MAEVDWIHRH PKAEDLRVGL ISWAGTYLTF EAYKSSVTAS AKSLGRRQTW ELLVSNEHES
     QAVIRLKSLQ GLYLLCEADG TVCYGRPRTS HHGCFLLRFH RNGKWTLQCI ISGRYLESDG
     EDVFCNSRVL SAYHMWTPRP ALHVHVILYS PIYHSYARAD HTVGRIWVDA AIPCLEECGF
     LLHFQDGCYH LETSTHHFLS RVDRLVPQRS SQTAFHMQVR PRGLVALCDG EGGTLYPQGS
     HLLLGMGSAP MKGEEWFVLQ HFPTWVSLKS KSRRFLSVIY DAEVCAASER LTQMSLFQYE
     CDSETPTLQL RSANGYYLAQ RRHRAIIADG HPMESDTFFR VHWNCGKITL QSPNGRFLGI
     ASDGLLMANV TIPGPNEELG IRFANRPFLV LRGRYGYVGS SSDHDLLKCN MDQPDCIQLL
     PCRQGIYHFQ AQGGSFWSIT SFGTFRPWGK FALNFCIELQ GSSLLTVLAP NGFYLRADRS
     GTLLADSEEI TKECIWEF