FSD1L_MOUSE
ID FSD1L_MOUSE Reviewed; 507 AA.
AC Q8BYN5; Q3USW7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=FSD1-like protein;
DE AltName: Full=Coiled-coil domain-containing protein 10;
DE AltName: Full=FSD1 N-terminal-like protein;
GN Name=Fsd1l; Synonyms=Ccdc10, Csdufd1, Fsd1nl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BYN5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BYN5-2; Sequence=VSP_039648;
CC Name=3;
CC IsoId=Q8BYN5-3; Sequence=VSP_039649, VSP_039650;
CC -!- MISCELLANEOUS: [Isoform 3]: Due to intron retention. {ECO:0000305}.
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DR EMBL; AK038893; BAC30161.1; -; mRNA.
DR EMBL; AK140020; BAE24213.1; -; mRNA.
DR EMBL; AL807745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS57276.1; -. [Q8BYN5-2]
DR RefSeq; NP_001182213.1; NM_001195284.1. [Q8BYN5-2]
DR RefSeq; NP_795940.1; NM_176966.4. [Q8BYN5-3]
DR AlphaFoldDB; Q8BYN5; -.
DR STRING; 10090.ENSMUSP00000124002; -.
DR iPTMnet; Q8BYN5; -.
DR PhosphoSitePlus; Q8BYN5; -.
DR MaxQB; Q8BYN5; -.
DR PaxDb; Q8BYN5; -.
DR PRIDE; Q8BYN5; -.
DR ProteomicsDB; 266868; -. [Q8BYN5-1]
DR ProteomicsDB; 266869; -. [Q8BYN5-2]
DR ProteomicsDB; 266870; -. [Q8BYN5-3]
DR Antibodypedia; 29292; 82 antibodies from 21 providers.
DR Ensembl; ENSMUST00000132151; ENSMUSP00000114931; ENSMUSG00000054752. [Q8BYN5-2]
DR GeneID; 319636; -.
DR KEGG; mmu:319636; -.
DR UCSC; uc012deh.1; mouse. [Q8BYN5-2]
DR CTD; 83856; -.
DR MGI; MGI:2442443; Fsd1l.
DR VEuPathDB; HostDB:ENSMUSG00000054752; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000157979; -.
DR HOGENOM; CLU_013137_19_1_1; -.
DR InParanoid; Q8BYN5; -.
DR OrthoDB; 527460at2759; -.
DR PhylomeDB; Q8BYN5; -.
DR TreeFam; TF333654; -.
DR BioGRID-ORCS; 319636; 0 hits in 68 CRISPR screens.
DR ChiTaRS; Fsd1l; mouse.
DR PRO; PR:Q8BYN5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BYN5; protein.
DR Bgee; ENSMUSG00000054752; Expressed in ventricular zone and 57 other tissues.
DR ExpressionAtlas; Q8BYN5; baseline and differential.
DR CDD; cd00063; FN3; 1.
DR CDD; cd12901; SPRY_PRY_FSD1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035742; SPRY/PRY_FSD1.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..507
FT /note="FSD1-like protein"
FT /id="PRO_0000089406"
FT DOMAIN 105..162
FT /note="COS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00586"
FT DOMAIN 164..268
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 291..484
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT REGION 292..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 70..109
FT /evidence="ECO:0000255"
FT COMPBIAS 296..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 498
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BXM9"
FT MOD_RES 501
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BXM9"
FT VAR_SEQ 116..131
FT /note="AARQIKDRVTMASAFR -> VNKTKSKRTDKSKTQF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_039649"
FT VAR_SEQ 132..507
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_039650"
FT VAR_SEQ 310..320
FT /note="SVHVTSLKKHT -> R (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_039648"
SQ SEQUENCE 507 AA; 56886 MW; EDBB0A7E7084DD98 CRC64;
MDSQKEALQR IISTLANKSD EIQNFIDTLN HTLKGVQENS SNILSELDEE FDSLYSILDD
VKESMISTIK QEQVRKSQEL QSQLSQCNNA LENSEELLEF ATRSLDIKEP EEFSKAARQI
KDRVTMASAF RLSLKPKVSD NMTHLMVDFS QERQMLQTLK FLPVPKAPEI DPVECLVADN
SVTVAWRMPE EDNKIDHFIM EYRKTNFDGL PRVKDERCWE VIDNIKGTEY TLSGLKFDSK
YMNFRVRACN KAVAGDYSDP VTLETRALNF SLDNSSSHLN LKVEDSCVEW DPTGGKGQES
KIKGKENKGS VHVTSLKKHT SGTPSPKRTS VGSRPPAVRG SRDRFTGESY TVLGDTAIEN
GQHYWEVKAQ KDCKSYSVGV AYKTLGKFDQ LGKTNTSWCV HVNSWLQNTF AAKHNNKVKA
LDVPVPEKIG VFCDFDGGQL SFYDAHSKQL LYSFKTKFTQ PVVPGFMVWC GGLSLSTGMQ
VPSAVRTLQK SENGMTGSTS SLNNVTQ
