FSD2_CAVPO
ID FSD2_CAVPO Reviewed; 719 AA.
AC H0UZ81;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2017, sequence version 2.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=Fibronectin type III and SPRY domain-containing protein 2;
GN Name=FSD2;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N;
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=28740084; DOI=10.1038/s41598-017-06395-6;
RA Benson M.A., Tinsley C.L., Waite A.J., Carlisle F.A., Sweet S.M.M.,
RA Ehler E., George C.H., Lai F.A., Martin-Rendon E., Blake D.J.;
RT "Ryanodine receptors are part of the myospryn complex in cardiac muscle.";
RL Sci. Rep. 7:6312-6312(2017).
CC -!- SUBUNIT: Interacts with CMYA5 (By similarity). In cardiac muscles,
CC identified in a complex composed of FSD2, CMYA5 and RYR2 (By
CC similarity). {ECO:0000250|UniProtKB:Q8BZ52}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28740084}.
CC Sarcoplasmic reticulum {ECO:0000269|PubMed:28740084}. Cytoplasm,
CC perinuclear region {ECO:0000269|PubMed:28740084}. Note=In skeletal
CC muscles and striated muscles flanks Z-disks (PubMed:28740084).
CC Partially colocalizes with RYR2 in the sarcoplasmic reticulum
CC (PubMed:28740084). {ECO:0000269|PubMed:28740084}.
CC -!- TISSUE SPECIFICITY: Expressed in skeletal and cardiac muscles.
CC {ECO:0000269|PubMed:28740084}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02016015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UZ81; -.
DR SMR; H0UZ81; -.
DR STRING; 10141.ENSCPOP00000002478; -.
DR Ensembl; ENSCPOT00000002763; ENSCPOP00000002478; ENSCPOG00000002729.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000158441; -.
DR HOGENOM; CLU_022856_0_0_1; -.
DR InParanoid; H0UZ81; -.
DR TreeFam; TF315216; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002729; Expressed in heart left ventricle and 1 other tissue.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IDA:UniProtKB.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50853; FN3; 2.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW Sarcoplasmic reticulum.
FT CHAIN 1..719
FT /note="Fibronectin type III and SPRY domain-containing
FT protein 2"
FT /id="PRO_0000445344"
FT DOMAIN 342..437
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 438..531
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 513..711
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT COILED 178..290
FT /evidence="ECO:0000255"
SQ SEQUENCE 719 AA; 82139 MW; 01A28E7AEF2E4D6E CRC64;
MEEEAGEEPR LDRPTAPKDF HFYNMDLYDS EDRLPLFPEE NTRLRRQTIQ AEMTYDPKEV
GNSFVDEGRM GVPAYPPYGI KRREPGWEQR DWRLEGEVET EDQDQDFSQW SMAGQSQALW
ESYRYTHGRA SEEYECYVIP EEEDEEEAAD LFCVTCRTPI RAVEKDFGEH KEHEVTPLSK
ALESAKEEIH KNMYKLEQQI IEMENFASHL EEVFITVEEN FGRQEQNFES HYNGILETLA
QKYEEKIQAL GEKKKEKLEA LYGQLVSCGE NLDTCKELME TIEEMCHEEK VDFLKVSNET
LGKFLKTKTD VEIAAQPEFE DQTLDFSDVE QLMGSMNTIL APSAPVINPQ APNSATGSSV
RVCWSLYADD TVESYQLSYR PVRDSLPGKE QAEFTVTVKE SYCSVTNLEP NTQYEFWVIA
QNRAGPSPSS EHAMYMTAPS PPIIKTEAIR SCEEAALICW ESGNLNPVDS YTVELTQVEE
PAASGVTESV VGIPICESLI QLQPGQSYTI CVRALNVGGP SARSTPATVR TTGSYFPLNK
ATCHPWLTIS EDGFTVIRSE RKNLTQELQP QQTQFTRCVA IMGNLIPVRG RHYWEIEMDE
HLDYTVGVAF EDVPKQEDLG ANGFSWCMRH TFASSRHKYE FLHNRTTPDI RITVPPKKIG
ILLDYENSKL SFFNVDIAQH LYTFSCQLQQ FVHPCFSLEK PGCLKIHNGI SMPMHATFY
