FSF1_SCHPO
ID FSF1_SCHPO Reviewed; 322 AA.
AC O13793;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Sideroflexin fsf1 {ECO:0000305};
DE AltName: Full=Fungal sideroflexin-1 {ECO:0000303|PubMed:17240176};
GN Name=fsf1 {ECO:0000303|PubMed:17240176, ECO:0000312|PomBase:SPAC17G6.15c};
GN ORFNames=SPAC17G6.15c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP GENE NAME.
RX PubMed=17240176; DOI=10.1016/j.fgb.2006.12.004;
RA Miotto G., Tessaro S., Rotta G.A., Bonatto D.;
RT "In silico analyses of Fsf1 sequences, a new group of fungal proteins
RT orthologous to the metazoan sideroblastic anemia-related sideroflexin
RT family.";
RL Fungal Genet. Biol. 44:740-753(2007).
CC -!- FUNCTION: Mitochondrial amino-acid transporter that mediates transport
CC of serine into mitochondria. {ECO:0000250|UniProtKB:Q12029}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q8CFD0, ECO:0000255,
CC ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16226.2; -; Genomic_DNA.
DR PIR; T37847; T37847.
DR RefSeq; NP_594262.2; NM_001019685.2.
DR AlphaFoldDB; O13793; -.
DR STRING; 4896.SPAC17G6.15c.1; -.
DR MaxQB; O13793; -.
DR PaxDb; O13793; -.
DR PRIDE; O13793; -.
DR EnsemblFungi; SPAC17G6.15c.1; SPAC17G6.15c.1:pep; SPAC17G6.15c.
DR GeneID; 2542199; -.
DR KEGG; spo:SPAC17G6.15c; -.
DR PomBase; SPAC17G6.15c; fsf1.
DR VEuPathDB; FungiDB:SPAC17G6.15c; -.
DR eggNOG; KOG3767; Eukaryota.
DR HOGENOM; CLU_039425_0_0_1; -.
DR InParanoid; O13793; -.
DR OMA; GRVRHCA; -.
DR PRO; PR:O13793; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0015194; F:L-serine transmembrane transporter activity; ISS:PomBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR GO; GO:0140300; P:serine import into mitochondrion; ISS:PomBase.
DR InterPro; IPR004686; Mtc.
DR PANTHER; PTHR11153; PTHR11153; 1.
DR Pfam; PF03820; SFXNs; 1.
DR TIGRFAMs; TIGR00798; mtc; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..322
FT /note="Sideroflexin fsf1"
FT /id="PRO_0000318075"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 35447 MW; E18BBD0BB98DD12B CRC64;
MSSNKLPTSK YDLSTYWGRV RHAMDITDPR TLLSTSQDLN SAVKTLEDYG AGKIAQLDET
VWHAKKIVDS TLHPDTKEPV FLPFRMSCFV LTNLVVTAGM LQPNLGTAGT VFWQWMNQSV
NVAFNSANAN KSTQLTLPQM TKSYIYAVSA SCGVAIGLNK IVPRMNFLSS SSKAVLGRLT
PFAAVASAGV LNVFLMRGEE LRQGIDVFDK EGESLGKSKK AAFYAVGETA LSRVINASPI
MVIPPLVLMR LQKQNWLRTR PKLTIPVNLG LITLTSLIAL PLAIGVFPAR EKISPFKLEP
QFHHLKDKSD QPIVEVEFNR GL
