FSH3_YEAST
ID FSH3_YEAST Reviewed; 266 AA.
AC Q99369; D6W2X9;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Family of serine hydrolases 3;
DE EC=3.1.-.-;
GN Name=FSH3; OrderedLocusNames=YOR280C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8896271;
RX DOI=10.1002/(sici)1097-0061(199609)12:10b%3c1059::aid-yea994%3e3.0.co;2-7;
RA Cheret G., Bernardi A., Sor F.J.;
RT "DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of
RT Saccharomyces cerevisiae.";
RL Yeast 12:1059-1064(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION.
RX PubMed=14645503; DOI=10.1074/mcp.m300082-mcp200;
RA Baxter S.M., Rosenblum J.S., Knutson S., Nelson M.R., Montimurro J.S.,
RA Di Gennaro J.A., Speir J.A., Burbaum J.J., Fetrow J.S.;
RT "Synergistic computational and experimental proteomics approaches for more
RT accurate detection of active serine hydrolases in yeast.";
RL Mol. Cell. Proteomics 3:209-225(2004).
RN [5]
RP INDUCTION.
RX PubMed=15494396; DOI=10.1074/jbc.m404669200;
RA Zaim J., Speina E., Kierzek A.M.;
RT "Identification of new genes regulated by the Crt1 transcription factor, an
RT effector of the DNA damage checkpoint pathway in Saccharomyces
RT cerevisiae.";
RL J. Biol. Chem. 280:28-37(2005).
CC -!- FUNCTION: Serine hydrolase of unknown specificity.
CC {ECO:0000269|PubMed:14645503}.
CC -!- INDUCTION: Regulated by RFX1/CRT1. {ECO:0000269|PubMed:15494396}.
CC -!- SIMILARITY: Belongs to the AB hydrolase 3 family. {ECO:0000305}.
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DR EMBL; X89633; CAA61785.1; -; Genomic_DNA.
DR EMBL; Z75188; CAA99506.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA11045.1; -; Genomic_DNA.
DR PIR; S67182; S67182.
DR RefSeq; NP_014923.1; NM_001183699.1.
DR AlphaFoldDB; Q99369; -.
DR SMR; Q99369; -.
DR BioGRID; 34668; 39.
DR IntAct; Q99369; 1.
DR STRING; 4932.YOR280C; -.
DR ESTHER; yeast-FSH3; FSH1.
DR MaxQB; Q99369; -.
DR PaxDb; Q99369; -.
DR PRIDE; Q99369; -.
DR EnsemblFungi; YOR280C_mRNA; YOR280C; YOR280C.
DR GeneID; 854454; -.
DR KEGG; sce:YOR280C; -.
DR SGD; S000005806; FSH3.
DR VEuPathDB; FungiDB:YOR280C; -.
DR eggNOG; KOG2551; Eukaryota.
DR GeneTree; ENSGT00390000003541; -.
DR HOGENOM; CLU_051938_2_2_1; -.
DR InParanoid; Q99369; -.
DR OMA; EEPTVCR; -.
DR BioCyc; YEAST:G3O-33767-MON; -.
DR PRO; PR:Q99369; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q99369; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR005645; FSH_dom.
DR Pfam; PF03959; FSH1; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome; Serine esterase.
FT CHAIN 1..266
FT /note="Family of serine hydrolases 3"
FT /id="PRO_0000212582"
FT ACT_SITE 117
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 180
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 209
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
SQ SEQUENCE 266 AA; 30418 MW; 4ECC438FF199B5A0 CRC64;
MSEKKKVLML HGFVQSDKIF SAKTGGLRKN LKKLGYDLYY PCAPHSIDKK ALFQSESEKG
RDAAKEFNTS ATSDEVYGWF FRNPESFNSF QIDQKVFNYL RNYVLENGPF DGVIGFSQGA
GLGGYLVTDF NRILNLTDEQ QPALKFFISF SGFKLEDQSY QKEYHRIIQV PSLHVRGELD
EVVAESRIMA LYESWPDNKR TLLVHPGAHF VPNSKPFVSQ VCNWIQGITS KEGQEHNAQP
EVDRKQFDKP QLEDDLLDMI DSLGKL
